Incidental Mutation 'R5323:Or5p5'
ID 404964
Institutional Source Beutler Lab
Gene Symbol Or5p5
Ensembl Gene ENSMUSG00000066242
Gene Name olfactory receptor family 5 subfamily P member 5
Synonyms MOR204-33P, Olfr467, GA_x6K02T2PBJ9-10144091-10145011
MMRRC Submission 042906-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5323 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 107413793-107414713 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107413883 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 33 (F33L)
Ref Sequence ENSEMBL: ENSMUSP00000081811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084756] [ENSMUST00000208563] [ENSMUST00000214253]
AlphaFold L7N455
Predicted Effect possibly damaging
Transcript: ENSMUST00000084756
AA Change: F33L

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000081811
Gene: ENSMUSG00000066242
AA Change: F33L

DomainStartEndE-ValueType
Pfam:7tm_4 33 308 5.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 37 307 8.3e-7 PFAM
Pfam:7tm_1 43 292 2.2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207203
Predicted Effect possibly damaging
Transcript: ENSMUST00000208563
AA Change: F31L

PolyPhen 2 Score 0.750 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214253
AA Change: F31L

PolyPhen 2 Score 0.750 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.9%
  • 20x: 96.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 82,206,269 (GRCm39) C784S probably damaging Het
Ahnak2 A T 12: 112,745,989 (GRCm39) probably benign Het
Apon A G 10: 128,090,907 (GRCm39) E195G probably damaging Het
Atxn10 A G 15: 85,275,944 (GRCm39) I334V probably benign Het
Camsap1 G T 2: 25,855,823 (GRCm39) A145E probably damaging Het
Capns1 G T 7: 29,887,147 (GRCm39) F243L possibly damaging Het
Catsper2 A T 2: 121,237,216 (GRCm39) I228N probably damaging Het
Ceacam14 A T 7: 17,549,402 (GRCm39) *264C probably null Het
Cel A C 2: 28,450,530 (GRCm39) V165G probably damaging Het
Cldnd1 T A 16: 58,550,016 (GRCm39) D66E possibly damaging Het
Cntnap5b T A 1: 100,311,275 (GRCm39) C589* probably null Het
Dnah3 T A 7: 119,620,234 (GRCm39) H1554L probably damaging Het
Fbxw25 T A 9: 109,492,573 (GRCm39) M55L probably benign Het
Fn1 T C 1: 71,636,591 (GRCm39) H2187R probably benign Het
Fsip2 A G 2: 82,818,489 (GRCm39) T4741A possibly damaging Het
Gabpa T A 16: 84,653,934 (GRCm39) I272N possibly damaging Het
Ganab T C 19: 8,886,049 (GRCm39) S212P probably benign Het
Ggt1 A G 10: 75,421,495 (GRCm39) probably null Het
Hpgds T C 6: 65,109,169 (GRCm39) T81A probably benign Het
Insr G A 8: 3,252,902 (GRCm39) T419I probably benign Het
Itgb7 A G 15: 102,140,059 (GRCm39) probably benign Het
Kcnt1 A G 2: 25,799,289 (GRCm39) I951V possibly damaging Het
Lrrc4c T A 2: 97,460,498 (GRCm39) C375S probably damaging Het
Muc17 G T 5: 137,175,537 (GRCm39) C44* probably null Het
Mycbpap A T 11: 94,394,330 (GRCm39) D313E probably benign Het
Neo1 A G 9: 58,813,931 (GRCm39) probably null Het
Ntsr2 C T 12: 16,709,934 (GRCm39) S405F probably benign Het
Nup153 G A 13: 46,870,682 (GRCm39) P21S probably benign Het
Obscn T A 11: 58,887,703 (GRCm39) E7705D probably benign Het
Ogn A G 13: 49,762,817 (GRCm39) D53G probably benign Het
Or10d5j A T 9: 39,868,125 (GRCm39) Y35* probably null Het
Or14j10 A T 17: 37,935,046 (GRCm39) I160K probably benign Het
Or5k8 G A 16: 58,645,066 (GRCm39) T2I probably benign Het
Or9i1b A T 19: 13,896,980 (GRCm39) I199F possibly damaging Het
Pde6a G A 18: 61,365,983 (GRCm39) R236H possibly damaging Het
Pigk T A 3: 152,443,837 (GRCm39) M85K probably damaging Het
Pirb A C 7: 3,719,598 (GRCm39) I516S possibly damaging Het
Polr3a T C 14: 24,505,009 (GRCm39) I1084V possibly damaging Het
Pum2 T A 12: 8,794,706 (GRCm39) I737N probably damaging Het
Recql5 A T 11: 115,818,215 (GRCm39) C159S probably damaging Het
Rxrg A G 1: 167,452,573 (GRCm39) N125S probably benign Het
Sgip1 C A 4: 102,823,477 (GRCm39) N699K probably damaging Het
Shprh G A 10: 11,046,041 (GRCm39) probably null Het
Smcp C T 3: 92,491,454 (GRCm39) G131D unknown Het
St8sia6 A G 2: 13,798,188 (GRCm39) L23P possibly damaging Het
Stk32c T A 7: 138,699,276 (GRCm39) T335S probably benign Het
Stox1 G A 10: 62,499,812 (GRCm39) A916V possibly damaging Het
Syk A T 13: 52,785,753 (GRCm39) T297S probably benign Het
Tert G T 13: 73,796,490 (GRCm39) A1074S probably benign Het
Tex9 A T 9: 72,385,187 (GRCm39) D135E probably damaging Het
Tmem132a G A 19: 10,841,371 (GRCm39) H318Y possibly damaging Het
Ttn A G 2: 76,738,249 (GRCm39) S4097P probably benign Het
Ush2a A T 1: 188,553,874 (GRCm39) probably null Het
Usp36 A T 11: 118,156,020 (GRCm39) S586T probably benign Het
Vsig8 A G 1: 172,388,244 (GRCm39) S71G probably benign Het
Zfp318 G A 17: 46,697,662 (GRCm39) D173N probably damaging Het
Zfp638 T A 6: 83,939,076 (GRCm39) S936T probably damaging Het
Zic2 A G 14: 122,713,728 (GRCm39) Y214C probably damaging Het
Other mutations in Or5p5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0110:Or5p5 UTSW 7 107,413,895 (GRCm39) missense probably damaging 1.00
R0450:Or5p5 UTSW 7 107,413,895 (GRCm39) missense probably damaging 1.00
R0707:Or5p5 UTSW 7 107,414,331 (GRCm39) missense probably damaging 0.99
R0918:Or5p5 UTSW 7 107,414,418 (GRCm39) missense probably benign 0.03
R1416:Or5p5 UTSW 7 107,414,469 (GRCm39) missense probably damaging 1.00
R1988:Or5p5 UTSW 7 107,413,907 (GRCm39) missense probably benign
R1989:Or5p5 UTSW 7 107,413,907 (GRCm39) missense probably benign
R2219:Or5p5 UTSW 7 107,414,429 (GRCm39) missense probably benign
R2241:Or5p5 UTSW 7 107,414,040 (GRCm39) missense possibly damaging 0.62
R2866:Or5p5 UTSW 7 107,414,126 (GRCm39) missense probably benign 0.06
R4946:Or5p5 UTSW 7 107,414,589 (GRCm39) missense possibly damaging 0.90
R4972:Or5p5 UTSW 7 107,413,953 (GRCm39) missense probably benign 0.10
R5099:Or5p5 UTSW 7 107,413,809 (GRCm39) missense probably benign 0.00
R5310:Or5p5 UTSW 7 107,414,171 (GRCm39) missense probably damaging 1.00
R5531:Or5p5 UTSW 7 107,414,451 (GRCm39) missense probably benign 0.03
R5672:Or5p5 UTSW 7 107,413,844 (GRCm39) missense probably damaging 1.00
R5758:Or5p5 UTSW 7 107,414,022 (GRCm39) missense probably damaging 0.99
R5891:Or5p5 UTSW 7 107,414,387 (GRCm39) missense probably damaging 1.00
R6016:Or5p5 UTSW 7 107,414,219 (GRCm39) missense probably benign 0.01
R6399:Or5p5 UTSW 7 107,413,961 (GRCm39) missense possibly damaging 0.78
R6466:Or5p5 UTSW 7 107,413,901 (GRCm39) missense probably benign
R6894:Or5p5 UTSW 7 107,414,271 (GRCm39) missense probably benign 0.25
R7543:Or5p5 UTSW 7 107,414,308 (GRCm39) missense probably damaging 1.00
R8316:Or5p5 UTSW 7 107,414,030 (GRCm39) missense possibly damaging 0.81
R9285:Or5p5 UTSW 7 107,413,821 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AAATGTGGAGTGGTGTATGTCAATC -3'
(R):5'- ACATCAGAGCCAAGCTGGAC -3'

Sequencing Primer
(F):5'- AGTGGTGTATGTCAATCATGAGG -3'
(R):5'- ACAGGGATGGCAGTTCTCTCTC -3'
Posted On 2016-07-22