Incidental Mutation 'R5324:Olfr1151'
ID 405004
Institutional Source Beutler Lab
Gene Symbol Olfr1151
Ensembl Gene ENSMUSG00000047039
Gene Name olfactory receptor 1151
Synonyms MOR177-9, GA_x6K02T2Q125-49358694-49359620
MMRRC Submission 042907-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R5324 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87855862-87859923 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87857696 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 174 (I174F)
Ref Sequence ENSEMBL: ENSMUSP00000151107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061081] [ENSMUST00000217376]
AlphaFold Q8VFQ8
Predicted Effect probably damaging
Transcript: ENSMUST00000061081
AA Change: I174F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055394
Gene: ENSMUSG00000047039
AA Change: I174F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.6e-45 PFAM
Pfam:7tm_1 41 290 1.7e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217376
AA Change: I174F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130019O22Rik G T 7: 127,384,907 probably benign Het
Akap10 C T 11: 61,916,189 A72T probably damaging Het
Ap5b1 G A 19: 5,569,835 E428K possibly damaging Het
Bmp2 C T 2: 133,561,359 R277* probably null Het
Cbl A T 9: 44,154,254 S659T probably damaging Het
Col14a1 A T 15: 55,338,445 H43L unknown Het
Corin A G 5: 72,435,257 C133R probably damaging Het
Cyp1a1 A G 9: 57,702,369 N401S probably benign Het
Dip2a T C 10: 76,296,393 D508G probably damaging Het
Dnah2 T A 11: 69,457,993 H2556L probably benign Het
Dock8 T C 19: 25,163,094 F1333L probably benign Het
Epg5 A G 18: 77,962,445 K717E possibly damaging Het
Fmn2 G A 1: 174,608,880 probably benign Het
Gm4787 G C 12: 81,377,830 T518S probably benign Het
Hbp1 T C 12: 31,928,618 N510S probably damaging Het
Lrguk T C 6: 34,073,797 S397P possibly damaging Het
Mmrn1 A T 6: 60,976,586 D617V probably damaging Het
Mroh9 C G 1: 163,060,760 G249R probably damaging Het
N6amt1 A G 16: 87,354,353 D34G probably damaging Het
Nktr A T 9: 121,727,346 D30V probably damaging Het
Olfr598 T A 7: 103,329,050 M188K probably damaging Het
Olfr805 T A 10: 129,722,945 I200L probably benign Het
Pabpc1 A G 15: 36,600,625 F314L probably damaging Het
Papln G A 12: 83,774,571 V226M probably damaging Het
Parp12 A T 6: 39,102,612 D321E probably damaging Het
Plch2 T A 4: 154,984,534 T1107S probably benign Het
Psma2 T C 13: 14,625,217 L182P probably damaging Het
Rcl1 A G 19: 29,128,001 Y196C probably benign Het
Rdh16 G A 10: 127,801,267 V24M probably damaging Het
Rpe65 A G 3: 159,604,404 T105A possibly damaging Het
Serpini1 T C 3: 75,640,294 I371T probably damaging Het
Tet2 T C 3: 133,485,913 N920S probably benign Het
Tmem71 C T 15: 66,555,214 S44N probably benign Het
Tmprss11f T A 5: 86,556,978 D27V possibly damaging Het
Zxdc T A 6: 90,373,800 I411N probably damaging Het
Other mutations in Olfr1151
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01755:Olfr1151 APN 2 87857510 missense possibly damaging 0.60
IGL02314:Olfr1151 APN 2 87858056 missense probably damaging 1.00
R0127:Olfr1151 UTSW 2 87857483 missense probably benign
R0233:Olfr1151 UTSW 2 87857752 missense probably benign 0.19
R0233:Olfr1151 UTSW 2 87857752 missense probably benign 0.19
R0398:Olfr1151 UTSW 2 87858057 missense probably damaging 1.00
R1079:Olfr1151 UTSW 2 87857355 missense probably damaging 1.00
R1598:Olfr1151 UTSW 2 87857751 missense probably benign 0.01
R1965:Olfr1151 UTSW 2 87857415 missense probably benign 0.44
R3409:Olfr1151 UTSW 2 87857661 nonsense probably null
R4824:Olfr1151 UTSW 2 87857277 missense probably benign 0.24
R4962:Olfr1151 UTSW 2 87857288 missense probably benign 0.02
R4986:Olfr1151 UTSW 2 87857514 missense probably damaging 0.97
R5934:Olfr1151 UTSW 2 87857241 missense probably benign
R6335:Olfr1151 UTSW 2 87857467 nonsense probably null
R6389:Olfr1151 UTSW 2 87858023 missense probably damaging 1.00
R6958:Olfr1151 UTSW 2 87857951 missense probably damaging 1.00
R7329:Olfr1151 UTSW 2 87857241 missense probably benign
R8228:Olfr1151 UTSW 2 87857940 missense probably benign 0.12
R8506:Olfr1151 UTSW 2 87857837 missense probably damaging 1.00
R8726:Olfr1151 UTSW 2 87857817 missense probably benign 0.14
R8845:Olfr1151 UTSW 2 87857201 missense probably benign 0.00
R9548:Olfr1151 UTSW 2 87857696 missense probably damaging 1.00
Z1177:Olfr1151 UTSW 2 87857424 missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TGCAGATTCTGAGTGTCTACTG -3'
(R):5'- TGCAGGTGGAGAAAGCTTTG -3'

Sequencing Primer
(F):5'- CAGATTCTGAGTGTCTACTGCTAGC -3'
(R):5'- GTGGAGAAAGCTTTGAACCTTCCC -3'
Posted On 2016-07-22