Incidental Mutation 'R5324:Or6c212'
ID 405026
Institutional Source Beutler Lab
Gene Symbol Or6c212
Ensembl Gene ENSMUSG00000096858
Gene Name olfactory receptor family 6 subfamily C member 212
Synonyms Olfr805, GA_x6K02T2PULF-11402237-11401278, MOR110-4
MMRRC Submission 042907-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5324 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129558452-129559411 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129558814 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 200 (I200L)
Ref Sequence ENSEMBL: ENSMUSP00000149493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078876] [ENSMUST00000204717] [ENSMUST00000216794] [ENSMUST00000217219]
AlphaFold Q8VFI4
Predicted Effect probably benign
Transcript: ENSMUST00000078876
AA Change: I200L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000092874
Gene: ENSMUSG00000096858
AA Change: I200L

Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203573
AA Change: I200L
SMART Domains Protein: ENSMUSP00000144843
Gene: ENSMUSG00000096858
AA Change: I200L

Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204717
Predicted Effect probably benign
Transcript: ENSMUST00000216794
AA Change: I200L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217219
AA Change: I200L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap10 C T 11: 61,807,015 (GRCm39) A72T probably damaging Het
Ap5b1 G A 19: 5,619,863 (GRCm39) E428K possibly damaging Het
Bmp2 C T 2: 133,403,279 (GRCm39) R277* probably null Het
Cbl A T 9: 44,065,551 (GRCm39) S659T probably damaging Het
Col14a1 A T 15: 55,201,841 (GRCm39) H43L unknown Het
Corin A G 5: 72,592,600 (GRCm39) C133R probably damaging Het
Cyp1a1 A G 9: 57,609,652 (GRCm39) N401S probably benign Het
Dip2a T C 10: 76,132,227 (GRCm39) D508G probably damaging Het
Dnah2 T A 11: 69,348,819 (GRCm39) H2556L probably benign Het
Dock8 T C 19: 25,140,458 (GRCm39) F1333L probably benign Het
Epg5 A G 18: 78,005,660 (GRCm39) K717E possibly damaging Het
Fmn2 G A 1: 174,436,446 (GRCm39) probably benign Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Hbp1 T C 12: 31,978,617 (GRCm39) N510S probably damaging Het
Lrguk T C 6: 34,050,732 (GRCm39) S397P possibly damaging Het
Mmrn1 A T 6: 60,953,570 (GRCm39) D617V probably damaging Het
Mroh9 C G 1: 162,888,329 (GRCm39) G249R probably damaging Het
N6amt1 A G 16: 87,151,241 (GRCm39) D34G probably damaging Het
Nktr A T 9: 121,556,412 (GRCm39) D30V probably damaging Het
Or52ab7 T A 7: 102,978,257 (GRCm39) M188K probably damaging Het
Or5w8 A T 2: 87,688,040 (GRCm39) I174F probably damaging Het
Pabpc1 A G 15: 36,600,869 (GRCm39) F314L probably damaging Het
Papln G A 12: 83,821,345 (GRCm39) V226M probably damaging Het
Parp12 A T 6: 39,079,546 (GRCm39) D321E probably damaging Het
Plch2 T A 4: 155,068,991 (GRCm39) T1107S probably benign Het
Psma2 T C 13: 14,799,802 (GRCm39) L182P probably damaging Het
Rcl1 A G 19: 29,105,401 (GRCm39) Y196C probably benign Het
Rdh16 G A 10: 127,637,136 (GRCm39) V24M probably damaging Het
Rpe65 A G 3: 159,310,041 (GRCm39) T105A possibly damaging Het
Serpini1 T C 3: 75,547,601 (GRCm39) I371T probably damaging Het
Tet2 T C 3: 133,191,674 (GRCm39) N920S probably benign Het
Tmem71 C T 15: 66,427,063 (GRCm39) S44N probably benign Het
Tmprss11f T A 5: 86,704,837 (GRCm39) D27V possibly damaging Het
Zfp747l1 G T 7: 126,984,079 (GRCm39) probably benign Het
Zxdc T A 6: 90,350,782 (GRCm39) I411N probably damaging Het
Other mutations in Or6c212
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Or6c212 APN 10 129,558,814 (GRCm39) missense probably benign
IGL01341:Or6c212 APN 10 129,558,747 (GRCm39) missense possibly damaging 0.87
IGL01960:Or6c212 APN 10 129,558,756 (GRCm39) missense probably damaging 1.00
IGL02729:Or6c212 APN 10 129,559,390 (GRCm39) missense probably benign 0.01
IGL02969:Or6c212 APN 10 129,559,065 (GRCm39) missense probably damaging 0.99
R0116:Or6c212 UTSW 10 129,558,846 (GRCm39) missense probably damaging 1.00
R1236:Or6c212 UTSW 10 129,558,675 (GRCm39) missense probably damaging 0.98
R1332:Or6c212 UTSW 10 129,559,116 (GRCm39) missense probably damaging 1.00
R2428:Or6c212 UTSW 10 129,558,652 (GRCm39) missense probably benign 0.05
R3725:Or6c212 UTSW 10 129,558,984 (GRCm39) missense probably damaging 1.00
R3726:Or6c212 UTSW 10 129,558,984 (GRCm39) missense probably damaging 1.00
R3804:Or6c212 UTSW 10 129,558,918 (GRCm39) missense possibly damaging 0.93
R4365:Or6c212 UTSW 10 129,559,281 (GRCm39) missense probably damaging 0.99
R4630:Or6c212 UTSW 10 129,559,350 (GRCm39) missense probably damaging 1.00
R4735:Or6c212 UTSW 10 129,558,792 (GRCm39) missense probably benign 0.06
R4923:Or6c212 UTSW 10 129,558,681 (GRCm39) missense probably benign 0.03
R4962:Or6c212 UTSW 10 129,558,592 (GRCm39) missense probably damaging 1.00
R5406:Or6c212 UTSW 10 129,558,799 (GRCm39) missense probably damaging 1.00
R7705:Or6c212 UTSW 10 129,559,018 (GRCm39) missense probably benign 0.01
R8464:Or6c212 UTSW 10 129,558,783 (GRCm39) missense possibly damaging 0.88
R9368:Or6c212 UTSW 10 129,558,881 (GRCm39) nonsense probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-07-22