Incidental Mutation 'R5189:Vmn1r84'
| ID |
405056 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r84
|
| Ensembl Gene |
ENSMUSG00000066803 |
| Gene Name |
vomeronasal 1 receptor 84 |
| Synonyms |
V1rg11 |
| MMRRC Submission |
042767-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
R5189 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
12095735-12096691 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 12096385 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 103
(S103T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083405
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086228]
[ENSMUST00000226408]
[ENSMUST00000227427]
[ENSMUST00000228653]
|
| AlphaFold |
Q8R284 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086228
AA Change: S103T
PolyPhen 2
Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000083405
Gene: ENSMUSG00000066803
AA Change: S103T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
16 |
312 |
3.7e-11 |
PFAM |
|
Pfam:V1R
|
45 |
308 |
1.9e-22 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177845
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226408
AA Change: S91T
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226811
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227427
AA Change: S91T
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228653
AA Change: S91T
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228741
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
C |
T |
12: 71,240,123 (GRCm39) |
T1311I |
possibly damaging |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 4930505A04Rik |
T |
C |
11: 30,376,169 (GRCm39) |
T233A |
probably damaging |
Het |
| Ankar |
T |
C |
1: 72,697,573 (GRCm39) |
I859V |
probably benign |
Het |
| Cacnb2 |
G |
T |
2: 14,990,849 (GRCm39) |
A644S |
possibly damaging |
Het |
| Gatb |
T |
C |
3: 85,544,238 (GRCm39) |
V402A |
probably benign |
Het |
| Gpcpd1 |
T |
C |
2: 132,395,892 (GRCm39) |
K153R |
probably damaging |
Het |
| Hip1 |
A |
G |
5: 135,463,147 (GRCm39) |
L60S |
probably damaging |
Het |
| Hsf4 |
GCAGCACCGGGTCA |
G |
8: 105,998,060 (GRCm39) |
|
probably null |
Het |
| Hydin |
A |
T |
8: 111,139,843 (GRCm39) |
|
probably null |
Het |
| Igsf3 |
A |
T |
3: 101,338,843 (GRCm39) |
T386S |
possibly damaging |
Het |
| Il12rb1 |
A |
G |
8: 71,263,702 (GRCm39) |
T88A |
possibly damaging |
Het |
| Kank1 |
T |
C |
19: 25,401,545 (GRCm39) |
S1051P |
probably damaging |
Het |
| Kap |
A |
G |
6: 133,828,879 (GRCm39) |
|
probably null |
Het |
| Ly96 |
A |
G |
1: 16,771,091 (GRCm39) |
E74G |
probably damaging |
Het |
| Map7d1 |
G |
T |
4: 126,136,097 (GRCm39) |
|
probably null |
Het |
| Megf6 |
G |
T |
4: 154,336,980 (GRCm39) |
R253L |
probably benign |
Het |
| Mex3b |
A |
G |
7: 82,518,459 (GRCm39) |
D258G |
probably damaging |
Het |
| Mpzl3 |
T |
C |
9: 44,973,408 (GRCm39) |
I49T |
possibly damaging |
Het |
| Myh15 |
C |
A |
16: 48,921,870 (GRCm39) |
T472N |
probably benign |
Het |
| Nacad |
A |
G |
11: 6,551,611 (GRCm39) |
S527P |
probably damaging |
Het |
| Nkx2-3 |
T |
G |
19: 43,601,147 (GRCm39) |
S70A |
probably benign |
Het |
| Nkx2-6 |
A |
T |
14: 69,409,342 (GRCm39) |
Q31L |
probably benign |
Het |
| Or6ae1 |
A |
G |
7: 139,742,632 (GRCm39) |
V77A |
probably damaging |
Het |
| Pcdha6 |
A |
T |
18: 37,101,844 (GRCm39) |
N346Y |
probably damaging |
Het |
| Pkd2 |
G |
A |
5: 104,607,785 (GRCm39) |
D95N |
probably benign |
Het |
| Pkhd1l1 |
A |
G |
15: 44,410,544 (GRCm39) |
T2684A |
probably damaging |
Het |
| Plin2 |
A |
G |
4: 86,575,383 (GRCm39) |
Y389H |
probably damaging |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Slc41a2 |
T |
C |
10: 83,149,275 (GRCm39) |
|
probably null |
Het |
| Smg6 |
A |
G |
11: 74,932,822 (GRCm39) |
T1038A |
probably damaging |
Het |
| Suds3 |
T |
C |
5: 117,238,664 (GRCm39) |
|
probably benign |
Het |
| Tbc1d8 |
T |
C |
1: 39,424,213 (GRCm39) |
H626R |
probably benign |
Het |
| Tmem260 |
T |
A |
14: 48,746,573 (GRCm39) |
H616Q |
probably benign |
Het |
| Trip10 |
A |
T |
17: 57,568,288 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubr4 |
A |
G |
4: 139,137,960 (GRCm39) |
T1106A |
probably benign |
Het |
| Vps13a |
G |
T |
19: 16,662,679 (GRCm39) |
P1602Q |
probably damaging |
Het |
|
| Other mutations in Vmn1r84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02505:Vmn1r84
|
APN |
7 |
12,096,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
K3955:Vmn1r84
|
UTSW |
7 |
12,095,884 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0360:Vmn1r84
|
UTSW |
7 |
12,095,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0399:Vmn1r84
|
UTSW |
7 |
12,095,794 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0697:Vmn1r84
|
UTSW |
7 |
12,096,690 (GRCm39) |
start codon destroyed |
probably null |
0.53 |
|
R1613:Vmn1r84
|
UTSW |
7 |
12,096,460 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1636:Vmn1r84
|
UTSW |
7 |
12,096,522 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1872:Vmn1r84
|
UTSW |
7 |
12,096,555 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4022:Vmn1r84
|
UTSW |
7 |
12,095,857 (GRCm39) |
missense |
probably benign |
|
|
R4923:Vmn1r84
|
UTSW |
7 |
12,095,743 (GRCm39) |
missense |
probably benign |
|
|
R5275:Vmn1r84
|
UTSW |
7 |
12,095,741 (GRCm39) |
missense |
probably benign |
|
|
R5721:Vmn1r84
|
UTSW |
7 |
12,096,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn1r84
|
UTSW |
7 |
12,095,841 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7261:Vmn1r84
|
UTSW |
7 |
12,096,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Vmn1r84
|
UTSW |
7 |
12,095,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7573:Vmn1r84
|
UTSW |
7 |
12,095,787 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8039:Vmn1r84
|
UTSW |
7 |
12,095,935 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8814:Vmn1r84
|
UTSW |
7 |
12,096,385 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn1r84
|
UTSW |
7 |
12,096,586 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Z1177:Vmn1r84
|
UTSW |
7 |
12,096,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTCCAATCACATCTATAGCTGTC -3'
(R):5'- TGGGAATCCTTGGTAACTGGTC -3'
Sequencing Primer
(F):5'- ATAGCTGTCTTGATGTTTAGAAGCAG -3'
(R):5'- GGAATCCTTGGTAACTGGTCAATTC -3'
|
| Posted On |
2016-07-22 |
Incidental Mutation