Mutagenetix > Incidental Mutation

Incidental Mutation 'R0497:Or4k37'

40513

Institutional Source

Beutler Lab

Gene Symbol

Or4k37

Ensembl Gene

ENSMUSG00000095156

Gene Name

olfactory receptor family 4 subfamily K member 37

Synonyms

GA_x6K02T2Q125-72379864-72380781, MOR248-18, MOR248-14P, Olfr1281

MMRRC Submission

038693-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R0497 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

111158766-111159683 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 111159175 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 137 (D137G)

Ref Sequence

ENSEMBL: ENSMUSP00000151304 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090326] [ENSMUST00000208176] [ENSMUST00000213551]

AlphaFold

Q7TQY6

Predicted Effect

probably benign
Transcript: ENSMUST00000090326
AA Change: D137G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000087798
Gene: ENSMUSG00000095156
AA Change: D137G

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	304	4.8e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	301	2.6e-6	PFAM
Pfam:7tm_1	41	287	4.8e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000208176
AA Change: D137G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000213551

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.6%
3x: 98.7%
10x: 96.6%
20x: 93.1%

Validation Efficiency

100% (68/68)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	A	C	11: 119,909,606 (GRCm39)	V110G	probably damaging	Het
Adcy6	A	C	15: 98,495,606 (GRCm39)		probably null	Het
Adm	A	G	7: 110,228,328 (GRCm39)	T170A	probably benign	Het
Afap1l2	G	T	19: 56,918,641 (GRCm39)	N171K	probably benign	Het
Aph1b	G	T	9: 66,697,900 (GRCm39)	S112*	probably null	Het
Arhgap23	A	G	11: 97,342,989 (GRCm39)	S424G	probably damaging	Het
Asah2	T	A	19: 32,032,031 (GRCm39)	N46I	probably benign	Het
Braf	G	A	6: 39,617,483 (GRCm39)		probably benign	Het
Brd2	C	T	17: 34,333,334 (GRCm39)	R47Q	probably damaging	Het
C2cd5	A	G	6: 142,957,819 (GRCm39)	V972A	probably benign	Het
Car9	T	A	4: 43,511,881 (GRCm39)	L300H	probably damaging	Het
Chmp3	T	C	6: 71,529,395 (GRCm39)	S20P	probably damaging	Het
Chp1	A	G	2: 119,402,263 (GRCm39)	N79S	possibly damaging	Het
Cnot2	A	T	10: 116,334,260 (GRCm39)	I335N	probably damaging	Het
Cntnap4	T	C	8: 113,296,783 (GRCm39)	V6A	probably benign	Het
Ctcf	T	A	8: 106,401,672 (GRCm39)		probably benign	Het
Dennd1b	A	G	1: 138,967,724 (GRCm39)		probably benign	Het
Dnmbp	A	G	19: 43,845,079 (GRCm39)		probably benign	Het
Eef2	T	C	10: 81,017,420 (GRCm39)	F782L	probably benign	Het
Eogt	T	A	6: 97,112,194 (GRCm39)	Y153F	probably benign	Het
Fam81a	G	T	9: 70,003,401 (GRCm39)	Q237K	possibly damaging	Het
Fat2	T	A	11: 55,174,228 (GRCm39)	T2162S	probably benign	Het
Fcgbpl1	T	A	7: 27,846,890 (GRCm39)	C1158S	probably damaging	Het
Gas6	T	C	8: 13,520,387 (GRCm39)	I434V	possibly damaging	Het
Gm42417	A	T	1: 36,571,248 (GRCm39)	L77Q	probably damaging	Het
Grik3	A	T	4: 125,517,303 (GRCm39)	N49Y	possibly damaging	Het
Gucy2e	A	T	11: 69,114,985 (GRCm39)	V974E	probably damaging	Het
Helz2	A	G	2: 180,871,449 (GRCm39)	V2721A	probably damaging	Het
Klhl6	GT	G	16: 19,775,716 (GRCm39)	279	probably null	Het
Krt73	A	G	15: 101,710,665 (GRCm39)	L23P	probably damaging	Het
L3mbtl3	T	C	10: 26,158,772 (GRCm39)		probably benign	Het
Lrrc15	A	T	16: 30,091,710 (GRCm39)	V543E	probably damaging	Het
Med13	G	A	11: 86,167,809 (GRCm39)		probably benign	Het
Med25	T	C	7: 44,541,524 (GRCm39)	D60G	probably damaging	Het
Mgam	T	A	6: 40,641,826 (GRCm39)	Y560N	probably damaging	Het
Mlkl	A	G	8: 112,054,505 (GRCm39)	Y211H	probably damaging	Het
Msl2	A	G	9: 100,978,493 (GRCm39)	N289S	probably benign	Het
Nwd2	G	T	5: 63,963,686 (GRCm39)	W1090L	probably damaging	Het
Omt2b	T	C	9: 78,235,513 (GRCm39)		probably benign	Het
Pald1	A	G	10: 61,177,094 (GRCm39)	L652P	probably damaging	Het
Pard3b	T	A	1: 62,479,167 (GRCm39)		probably null	Het
Prdm15	G	A	16: 97,595,534 (GRCm39)	T1098I	possibly damaging	Het
Rock2	A	G	12: 17,004,954 (GRCm39)	T436A	probably benign	Het
Sema4c	A	T	1: 36,588,689 (GRCm39)	D812E	probably benign	Het
Sla	A	T	15: 66,664,098 (GRCm39)	I91K	probably benign	Het
Slc22a16	T	G	10: 40,460,963 (GRCm39)	M255R	probably damaging	Het
Slc49a4	A	T	16: 35,555,974 (GRCm39)	V162D	probably benign	Het
Smg8	C	T	11: 86,976,910 (GRCm39)	D224N	possibly damaging	Het
Spdef	A	T	17: 27,937,032 (GRCm39)	D190E	probably benign	Het
Taok1	A	G	11: 77,464,630 (GRCm39)	I152T	probably damaging	Het
Tmem220	A	G	11: 66,916,748 (GRCm39)	D36G	probably damaging	Het
Tmem235	A	C	11: 117,755,177 (GRCm39)	I210L	probably benign	Het
Tmem266	C	T	9: 55,288,168 (GRCm39)		probably null	Het
Tmprss12	A	G	15: 100,178,920 (GRCm39)		probably benign	Het
Trim32	G	A	4: 65,531,491 (GRCm39)	R16Q	probably damaging	Het
Usp38	T	A	8: 81,711,053 (GRCm39)		probably benign	Het
Usp44	C	T	10: 93,682,668 (GRCm39)	P373S	possibly damaging	Het
Vmn1r209	G	T	13: 22,990,118 (GRCm39)	Q191K	probably damaging	Het
Vmn1r70	T	C	7: 10,367,953 (GRCm39)	I147T	probably benign	Het
Vmn2r107	T	A	17: 20,595,394 (GRCm39)	I649N	probably damaging	Het
Vmn2r12	A	T	5: 109,239,755 (GRCm39)	Y269*	probably null	Het
Zan	C	T	5: 137,410,938 (GRCm39)		probably benign	Het
Zfp616	G	T	11: 73,974,306 (GRCm39)	V192L	probably benign	Het
Zfp644	A	T	5: 106,786,199 (GRCm39)	V116D	probably damaging	Het
Zgrf1	T	C	3: 127,378,299 (GRCm39)		probably benign	Het
Zhx3	A	T	2: 160,621,914 (GRCm39)	L751*	probably null	Het
Znfx1	T	A	2: 166,897,331 (GRCm39)	Q531L	probably benign	Het

Other mutations in Or4k37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02426:Or4k37	APN	2	111,158,920 (GRCm39)	missense	probably damaging	1.00
IGL02550:Or4k37	APN	2	111,158,845 (GRCm39)	missense	probably damaging	1.00
IGL02553:Or4k37	APN	2	111,159,333 (GRCm39)	missense	probably benign
IGL02719:Or4k37	APN	2	111,159,590 (GRCm39)	nonsense	probably null
IGL02750:Or4k37	APN	2	111,159,633 (GRCm39)	missense	probably damaging	1.00
IGL02873:Or4k37	APN	2	111,159,217 (GRCm39)	missense	probably benign
IGL03252:Or4k37	APN	2	111,159,125 (GRCm39)	nonsense	probably null
IGL03375:Or4k37	APN	2	111,159,229 (GRCm39)	missense	probably damaging	1.00
R0055:Or4k37	UTSW	2	111,158,870 (GRCm39)	nonsense	probably null
R0368:Or4k37	UTSW	2	111,159,132 (GRCm39)	missense	probably damaging	0.99
R0505:Or4k37	UTSW	2	111,159,673 (GRCm39)	missense	probably benign	0.00
R1557:Or4k37	UTSW	2	111,158,964 (GRCm39)	missense	probably damaging	1.00
R1619:Or4k37	UTSW	2	111,159,306 (GRCm39)	missense	probably benign	0.02
R1691:Or4k37	UTSW	2	111,159,198 (GRCm39)	missense	probably benign	0.03
R2286:Or4k37	UTSW	2	111,159,252 (GRCm39)	missense	probably benign	0.01
R4230:Or4k37	UTSW	2	111,159,475 (GRCm39)	missense	probably damaging	1.00
R4274:Or4k37	UTSW	2	111,159,160 (GRCm39)	missense	probably damaging	0.98
R4305:Or4k37	UTSW	2	111,159,643 (GRCm39)	missense	probably null	0.82
R4495:Or4k37	UTSW	2	111,159,365 (GRCm39)	missense	probably benign	0.08
R5307:Or4k37	UTSW	2	111,158,741 (GRCm39)	splice site	probably null
R6115:Or4k37	UTSW	2	111,159,558 (GRCm39)	missense	probably benign	0.03
R6615:Or4k37	UTSW	2	111,159,457 (GRCm39)	missense	probably benign	0.00
R7169:Or4k37	UTSW	2	111,158,943 (GRCm39)	missense	probably damaging	1.00
R7601:Or4k37	UTSW	2	111,159,565 (GRCm39)	missense	probably benign	0.12
R8267:Or4k37	UTSW	2	111,159,160 (GRCm39)	missense	probably benign	0.22
R8447:Or4k37	UTSW	2	111,159,307 (GRCm39)	missense	possibly damaging	0.81
R8749:Or4k37	UTSW	2	111,158,817 (GRCm39)	missense	possibly damaging	0.93
R8795:Or4k37	UTSW	2	111,158,881 (GRCm39)	nonsense	probably null
R9269:Or4k37	UTSW	2	111,159,297 (GRCm39)	missense	probably damaging	1.00
R9598:Or4k37	UTSW	2	111,159,633 (GRCm39)	nonsense	probably null
R9679:Or4k37	UTSW	2	111,159,345 (GRCm39)	missense	probably benign	0.00
Z1177:Or4k37	UTSW	2	111,159,170 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- AGGGACTGTGTACCTCAAGGCAAC -3'
(R):5'- TCCACCCAAGTGATGTTTACTGGC -3'

Sequencing Primer
(F):5'- ttctcttattaccattttctgtcctc -3'
(R):5'- GCCACTGTCAGCATTTATTAGG -3'

Posted On

2013-05-23