Incidental Mutation 'R5292:Or5w1b'
ID 405179
Institutional Source Beutler Lab
Gene Symbol Or5w1b
Ensembl Gene ENSMUSG00000075155
Gene Name olfactory receptor family 5 subfamily W member 1B
Synonyms GA_x6K02T2Q125-49151278-49150337, Olfr1133, MOR176-2
MMRRC Submission 042875-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5292 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87475524-87476465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87476339 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 43 (N43Y)
Ref Sequence ENSEMBL: ENSMUSP00000149460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099855] [ENSMUST00000217368]
AlphaFold Q7TR44
Predicted Effect probably damaging
Transcript: ENSMUST00000099855
AA Change: N43Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097441
Gene: ENSMUSG00000075155
AA Change: N43Y

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_4 32 308 7e-51 PFAM
Pfam:7tm_1 42 291 1.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217368
AA Change: N43Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A G 8: 25,354,467 (GRCm39) V641A possibly damaging Het
Apob A T 12: 8,055,912 (GRCm39) M1465L probably benign Het
Astn1 T C 1: 158,407,933 (GRCm39) probably null Het
Bend7 G A 2: 4,768,052 (GRCm39) R336Q probably damaging Het
Col22a1 T C 15: 71,842,185 (GRCm39) Y433C probably damaging Het
Crtc3 T C 7: 80,268,358 (GRCm39) T154A possibly damaging Het
Dcc T C 18: 71,439,159 (GRCm39) Y1241C probably damaging Het
Depdc1b T C 13: 108,510,376 (GRCm39) V296A probably damaging Het
Gata3 A G 2: 9,873,685 (GRCm39) S270P probably damaging Het
Gcm1 T C 9: 77,968,708 (GRCm39) F136S probably damaging Het
Gfpt1 A G 6: 87,053,237 (GRCm39) probably null Het
Gm5174 G T 10: 86,492,562 (GRCm39) noncoding transcript Het
Hhipl1 A G 12: 108,294,037 (GRCm39) T648A probably benign Het
Hr C A 14: 70,809,432 (GRCm39) Q1177K probably damaging Het
Hrnr T C 3: 93,239,199 (GRCm39) S3146P unknown Het
Igkv10-94 C T 6: 68,681,582 (GRCm39) G86E probably damaging Het
Krt80 G A 15: 101,250,066 (GRCm39) R222W probably damaging Het
Lrch3 T C 16: 32,796,177 (GRCm39) Y354H probably damaging Het
Or10g1 A T 14: 52,647,902 (GRCm39) N142K possibly damaging Het
Or3a1b T A 11: 74,012,877 (GRCm39) F254Y probably damaging Het
Osbpl7 A G 11: 96,958,779 (GRCm39) D932G probably benign Het
Pakap T G 4: 57,855,356 (GRCm39) S471R probably damaging Het
Palmd T C 3: 116,717,393 (GRCm39) E368G probably benign Het
Peg3 T A 7: 6,711,259 (GRCm39) D1321V probably damaging Het
Pkhd1l1 A T 15: 44,392,962 (GRCm39) I1766F probably damaging Het
Polq A G 16: 36,881,745 (GRCm39) E1303G probably damaging Het
Ppie A G 4: 123,033,701 (GRCm39) Y9H probably damaging Het
Ptprz1 A G 6: 23,002,581 (GRCm39) N1557S probably benign Het
Rnf40 T C 7: 127,195,120 (GRCm39) V411A possibly damaging Het
Rtn4 T C 11: 29,657,924 (GRCm39) F577L probably benign Het
Sacs A G 14: 61,449,432 (GRCm39) Y3826C probably damaging Het
Slc32a1 A G 2: 158,453,307 (GRCm39) D49G probably damaging Het
Slc37a2 A T 9: 37,150,453 (GRCm39) C167* probably null Het
Slc5a1 G T 5: 33,315,585 (GRCm39) V535F probably benign Het
Smoc2 A G 17: 14,556,835 (GRCm39) K95E probably damaging Het
Smok3c A C 5: 138,063,446 (GRCm39) Q311P probably damaging Het
Spink5 C A 18: 44,139,521 (GRCm39) P628Q probably benign Het
Spint4 T C 2: 164,542,779 (GRCm39) L124S probably benign Het
Stard9 A G 2: 120,529,626 (GRCm39) K1961R probably benign Het
Synpo2 C A 3: 122,907,709 (GRCm39) V536L possibly damaging Het
Trim24 A G 6: 37,880,539 (GRCm39) K146E probably benign Het
Usp24 A G 4: 106,275,460 (GRCm39) D2245G probably benign Het
Vars2 A G 17: 35,971,678 (GRCm39) S81P probably damaging Het
Zfp39 T C 11: 58,791,415 (GRCm39) T91A probably damaging Het
Zfp764l1 T C 7: 126,991,659 (GRCm39) D97G possibly damaging Het
Zfp936 T A 7: 42,838,759 (GRCm39) Y75* probably null Het
Zkscan5 G T 5: 145,155,451 (GRCm39) C374F probably damaging Het
Other mutations in Or5w1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Or5w1b APN 2 87,475,630 (GRCm39) missense probably damaging 1.00
IGL03354:Or5w1b APN 2 87,475,939 (GRCm39) missense probably damaging 0.99
PIT4366001:Or5w1b UTSW 2 87,475,534 (GRCm39) nonsense probably null
R1375:Or5w1b UTSW 2 87,476,081 (GRCm39) missense probably damaging 1.00
R1413:Or5w1b UTSW 2 87,476,182 (GRCm39) missense probably benign 0.02
R2011:Or5w1b UTSW 2 87,476,233 (GRCm39) missense probably damaging 0.97
R2016:Or5w1b UTSW 2 87,476,396 (GRCm39) missense probably benign 0.18
R2026:Or5w1b UTSW 2 87,475,753 (GRCm39) missense probably damaging 1.00
R2106:Or5w1b UTSW 2 87,475,895 (GRCm39) missense probably damaging 1.00
R4393:Or5w1b UTSW 2 87,476,256 (GRCm39) nonsense probably null
R5562:Or5w1b UTSW 2 87,476,063 (GRCm39) missense probably benign 0.00
R5631:Or5w1b UTSW 2 87,475,952 (GRCm39) missense probably benign 0.16
R5632:Or5w1b UTSW 2 87,475,573 (GRCm39) missense probably damaging 1.00
R6801:Or5w1b UTSW 2 87,475,667 (GRCm39) missense probably benign 0.23
R7014:Or5w1b UTSW 2 87,476,320 (GRCm39) missense probably damaging 1.00
R7963:Or5w1b UTSW 2 87,475,769 (GRCm39) missense probably benign 0.16
R8769:Or5w1b UTSW 2 87,475,960 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGACATTCTACATCTGCAAAGGC -3'
(R):5'- ACCAAGAATCTGACTATGAACAGAG -3'

Sequencing Primer
(F):5'- GTGGAATAGCAGATGTCAC -3'
(R):5'- ATCCAGGATATCCAGATCC -3'
Posted On 2016-07-22