Incidental Mutation 'R5294:Vmn2r98'
| ID |
405331 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r98
|
| Ensembl Gene |
ENSMUSG00000096717 |
| Gene Name |
vomeronasal 2, receptor 98 |
| Synonyms |
EG224552 |
| MMRRC Submission |
042877-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
R5294 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19053460-19082411 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 19069754 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 517
(C517*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
| AlphaFold |
E9PZ56 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000170424
AA Change: C517*
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: C517*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 96.0%
|
| Validation Efficiency |
97% (70/72) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930579C12Rik |
T |
C |
9: 89,152,003 |
|
noncoding transcript |
Het |
| Acaca |
A |
G |
11: 84,391,519 |
E2154G |
probably benign |
Het |
| Acacb |
T |
C |
5: 114,241,952 |
F2056L |
probably damaging |
Het |
| Aff1 |
A |
G |
5: 103,811,157 |
|
probably benign |
Het |
| Amn1 |
T |
A |
6: 149,185,124 |
|
probably benign |
Het |
| Arid1a |
C |
A |
4: 133,691,055 |
|
probably benign |
Het |
| Aste1 |
T |
A |
9: 105,402,705 |
|
probably null |
Het |
| Asxl3 |
T |
A |
18: 22,516,439 |
V495D |
possibly damaging |
Het |
| Atp1a3 |
T |
A |
7: 24,988,048 |
H688L |
probably damaging |
Het |
| B3gnt8 |
T |
C |
7: 25,628,766 |
L207P |
probably damaging |
Het |
| Baz2b |
T |
C |
2: 59,978,602 |
H101R |
probably benign |
Het |
| Bicc1 |
G |
A |
10: 70,947,900 |
T387M |
possibly damaging |
Het |
| Champ1 |
A |
C |
8: 13,878,981 |
K380Q |
probably damaging |
Het |
| Cnst |
A |
G |
1: 179,610,440 |
E523G |
probably benign |
Het |
| Cops6 |
G |
C |
5: 138,161,116 |
|
probably benign |
Het |
| Cp |
G |
C |
3: 19,966,316 |
V158L |
probably benign |
Het |
| Cyfip1 |
T |
A |
7: 55,873,483 |
M52K |
possibly damaging |
Het |
| Dars |
A |
T |
1: 128,364,302 |
F480I |
probably benign |
Het |
| Diaph1 |
T |
C |
18: 37,897,580 |
M274V |
unknown |
Het |
| Diaph1 |
C |
A |
18: 37,897,550 |
E284* |
probably null |
Het |
| Dock8 |
G |
A |
19: 25,061,153 |
V68M |
probably benign |
Het |
| Elavl4 |
A |
G |
4: 110,211,430 |
F247L |
possibly damaging |
Het |
| Emc10 |
C |
T |
7: 44,496,439 |
|
probably benign |
Het |
| Fbxw16 |
T |
C |
9: 109,436,644 |
D369G |
probably benign |
Het |
| Fgr |
A |
T |
4: 132,997,500 |
D304V |
probably benign |
Het |
| Filip1l |
G |
A |
16: 57,570,036 |
S91N |
possibly damaging |
Het |
| Gm884 |
A |
G |
11: 103,616,231 |
|
probably benign |
Het |
| Haus8 |
A |
G |
8: 71,255,710 |
S103P |
unknown |
Het |
| Hscb |
A |
G |
5: 110,834,792 |
L143P |
probably damaging |
Het |
| Hsd11b2 |
A |
T |
8: 105,523,297 |
M347L |
probably benign |
Het |
| Jrk |
C |
A |
15: 74,707,336 |
E33D |
possibly damaging |
Het |
| Kbtbd8 |
T |
A |
6: 95,121,832 |
Y123* |
probably null |
Het |
| Mis18bp1 |
A |
C |
12: 65,157,043 |
M59R |
probably damaging |
Het |
| Mrps27 |
T |
C |
13: 99,409,873 |
V260A |
probably damaging |
Het |
| Ncapg2 |
G |
T |
12: 116,427,794 |
V488L |
possibly damaging |
Het |
| Nepn |
A |
T |
10: 52,400,800 |
N211Y |
probably benign |
Het |
| Ntrk3 |
A |
T |
7: 78,517,506 |
|
probably null |
Het |
| Olfr248 |
A |
T |
1: 174,391,225 |
Y52F |
probably benign |
Het |
| Olfr692 |
C |
T |
7: 105,368,413 |
T20I |
probably benign |
Het |
| Olfr748 |
A |
G |
14: 50,710,443 |
T38A |
possibly damaging |
Het |
| Olfr748 |
A |
G |
14: 50,710,779 |
I150V |
probably benign |
Het |
| Otud4 |
A |
T |
8: 79,672,892 |
Q744L |
possibly damaging |
Het |
| P2ry14 |
A |
T |
3: 59,115,568 |
I166N |
possibly damaging |
Het |
| Pak2 |
T |
A |
16: 32,021,830 |
N478Y |
probably damaging |
Het |
| Papss2 |
A |
G |
19: 32,639,000 |
D202G |
probably benign |
Het |
| Pcdh7 |
C |
A |
5: 57,728,111 |
|
probably null |
Het |
| Peg3 |
C |
A |
7: 6,717,849 |
S19I |
possibly damaging |
Het |
| Prim2 |
G |
T |
1: 33,668,893 |
T40K |
probably benign |
Het |
| Ranbp2 |
T |
C |
10: 58,478,668 |
F1737L |
probably benign |
Het |
| Rex2 |
A |
C |
4: 147,057,985 |
N310T |
probably benign |
Het |
| Rnf123 |
AT |
ATT |
9: 108,064,003 |
|
probably null |
Het |
| Rnf39 |
C |
T |
17: 36,947,200 |
A86V |
probably damaging |
Het |
| Ror1 |
A |
T |
4: 100,425,938 |
N400I |
probably benign |
Het |
| Slc38a8 |
C |
T |
8: 119,494,289 |
G177D |
probably damaging |
Het |
| Slc43a3 |
T |
C |
2: 84,956,310 |
V445A |
probably benign |
Het |
| Sptbn2 |
A |
G |
19: 4,718,908 |
N23S |
possibly damaging |
Het |
| Taf5l |
A |
G |
8: 124,008,218 |
F74L |
probably benign |
Het |
| Trappc11 |
G |
C |
8: 47,530,731 |
A42G |
possibly damaging |
Het |
| Trim30d |
T |
C |
7: 104,472,488 |
K350R |
probably damaging |
Het |
| Trnt1 |
T |
C |
6: 106,773,414 |
F93S |
probably damaging |
Het |
| Ube2c |
T |
C |
2: 164,777,190 |
V161A |
probably benign |
Het |
| Usp24 |
A |
G |
4: 106,362,357 |
E555G |
possibly damaging |
Het |
| Vmn2r55 |
T |
G |
7: 12,651,864 |
S730R |
probably damaging |
Het |
| Vmn2r89 |
T |
A |
14: 51,455,113 |
N124K |
probably benign |
Het |
| Vps13a |
A |
T |
19: 16,641,667 |
I2845N |
probably damaging |
Het |
| Vps51 |
T |
G |
19: 6,071,033 |
E283D |
probably benign |
Het |
| Xpo5 |
T |
C |
17: 46,236,922 |
V896A |
probably benign |
Het |
| Zfp2 |
T |
C |
11: 50,901,241 |
|
probably benign |
Het |
| Zgrf1 |
G |
A |
3: 127,600,980 |
M1328I |
probably benign |
Het |
| Zswim5 |
A |
G |
4: 116,979,577 |
D686G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r98 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r98
|
APN |
17 |
19,065,745 (GRCm38) |
splice site |
probably benign |
|
|
IGL01296:Vmn2r98
|
APN |
17 |
19,065,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01363:Vmn2r98
|
APN |
17 |
19,065,758 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01618:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01746:Vmn2r98
|
APN |
17 |
19,066,451 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01747:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01770:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01868:Vmn2r98
|
APN |
17 |
19,066,286 (GRCm38) |
missense |
probably benign |
|
|
IGL02123:Vmn2r98
|
APN |
17 |
19,080,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r98
|
APN |
17 |
19,065,851 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02543:Vmn2r98
|
APN |
17 |
19,065,821 (GRCm38) |
missense |
probably benign |
|
|
IGL02650:Vmn2r98
|
APN |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02676:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02803:Vmn2r98
|
APN |
17 |
19,066,013 (GRCm38) |
missense |
probably benign |
|
|
IGL02807:Vmn2r98
|
APN |
17 |
19,081,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03307:Vmn2r98
|
APN |
17 |
19,065,980 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
IGL03396:Vmn2r98
|
APN |
17 |
19,069,845 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0122:Vmn2r98
|
UTSW |
17 |
19,066,400 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0329:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0330:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0368:Vmn2r98
|
UTSW |
17 |
19,065,827 (GRCm38) |
nonsense |
probably null |
|
|
R0545:Vmn2r98
|
UTSW |
17 |
19,053,613 (GRCm38) |
missense |
probably benign |
0.15 |
|
R0635:Vmn2r98
|
UTSW |
17 |
19,080,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0689:Vmn2r98
|
UTSW |
17 |
19,080,520 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1035:Vmn2r98
|
UTSW |
17 |
19,080,749 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1243:Vmn2r98
|
UTSW |
17 |
19,065,948 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R1421:Vmn2r98
|
UTSW |
17 |
19,065,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1629:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1643:Vmn2r98
|
UTSW |
17 |
19,080,908 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1795:Vmn2r98
|
UTSW |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1958:Vmn2r98
|
UTSW |
17 |
19,066,418 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R1962:Vmn2r98
|
UTSW |
17 |
19,065,333 (GRCm38) |
nonsense |
probably null |
|
|
R2165:Vmn2r98
|
UTSW |
17 |
19,081,291 (GRCm38) |
missense |
unknown |
|
|
R2238:Vmn2r98
|
UTSW |
17 |
19,065,951 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2252:Vmn2r98
|
UTSW |
17 |
19,080,436 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2323:Vmn2r98
|
UTSW |
17 |
19,065,819 (GRCm38) |
missense |
probably benign |
0.18 |
|
R2887:Vmn2r98
|
UTSW |
17 |
19,081,177 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R2909:Vmn2r98
|
UTSW |
17 |
19,067,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3001:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3002:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3003:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3788:Vmn2r98
|
UTSW |
17 |
19,080,625 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4570:Vmn2r98
|
UTSW |
17 |
19,066,092 (GRCm38) |
missense |
probably benign |
0.11 |
|
R4706:Vmn2r98
|
UTSW |
17 |
19,069,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4723:Vmn2r98
|
UTSW |
17 |
19,066,340 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5036:Vmn2r98
|
UTSW |
17 |
19,066,157 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5072:Vmn2r98
|
UTSW |
17 |
19,066,044 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5121:Vmn2r98
|
UTSW |
17 |
19,053,553 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5283:Vmn2r98
|
UTSW |
17 |
19,080,719 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5371:Vmn2r98
|
UTSW |
17 |
19,069,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5598:Vmn2r98
|
UTSW |
17 |
19,080,899 (GRCm38) |
missense |
probably benign |
0.37 |
|
R5800:Vmn2r98
|
UTSW |
17 |
19,065,998 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6089:Vmn2r98
|
UTSW |
17 |
19,066,074 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6155:Vmn2r98
|
UTSW |
17 |
19,065,881 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6853:Vmn2r98
|
UTSW |
17 |
19,065,801 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r98
|
UTSW |
17 |
19,065,248 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7012:Vmn2r98
|
UTSW |
17 |
19,066,268 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7042:Vmn2r98
|
UTSW |
17 |
19,080,922 (GRCm38) |
missense |
probably benign |
|
|
R7068:Vmn2r98
|
UTSW |
17 |
19,065,313 (GRCm38) |
missense |
probably benign |
|
|
R7607:Vmn2r98
|
UTSW |
17 |
19,067,308 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7763:Vmn2r98
|
UTSW |
17 |
19,080,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7771:Vmn2r98
|
UTSW |
17 |
19,067,198 (GRCm38) |
splice site |
probably null |
|
|
R7915:Vmn2r98
|
UTSW |
17 |
19,067,231 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8028:Vmn2r98
|
UTSW |
17 |
19,053,650 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8205:Vmn2r98
|
UTSW |
17 |
19,081,163 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8241:Vmn2r98
|
UTSW |
17 |
19,080,769 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8906:Vmn2r98
|
UTSW |
17 |
19,066,270 (GRCm38) |
missense |
probably benign |
|
|
R8952:Vmn2r98
|
UTSW |
17 |
19,065,269 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R9147:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9148:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9187:Vmn2r98
|
UTSW |
17 |
19,081,219 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9344:Vmn2r98
|
UTSW |
17 |
19,066,515 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9467:Vmn2r98
|
UTSW |
17 |
19,067,255 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9487:Vmn2r98
|
UTSW |
17 |
19,081,234 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9753:Vmn2r98
|
UTSW |
17 |
19,065,403 (GRCm38) |
missense |
probably benign |
0.27 |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,067,423 (GRCm38) |
nonsense |
probably null |
|
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,065,136 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAATTTCTGTTAGCTACCCCAGTAC -3'
(R):5'- AGGTACTGGGGAATATATCTTCCAATG -3'
Sequencing Primer
(F):5'- GTTAGCTACCCCAGTACCCTATC -3'
(R):5'- GGCTGTTTTGAACTAATTAAAGGGG -3'
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| Posted On |
2016-07-22 |
Incidental Mutation