Incidental Mutation 'R5297:Stk38l'
ID405479
Institutional Source Beutler Lab
Gene Symbol Stk38l
Ensembl Gene ENSMUSG00000001630
Gene Nameserine/threonine kinase 38 like
Synonyms4930473A22Rik, Ndr2
MMRRC Submission 042880-MU
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.559) question?
Stock #R5297 (G1)
Quality Score225
Status Not validated
Chromosome6
Chromosomal Location146724995-146778812 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 146775655 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 450 (Y450*)
Ref Sequence ENSEMBL: ENSMUSP00000107271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001675] [ENSMUST00000111644]
Predicted Effect probably null
Transcript: ENSMUST00000001675
AA Change: Y443*
SMART Domains Protein: ENSMUSP00000001675
Gene: ENSMUSG00000001630
AA Change: Y443*

DomainStartEndE-ValueType
S_TKc 90 383 5.62e-100 SMART
S_TK_X 384 445 2.88e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000111644
AA Change: Y450*
SMART Domains Protein: ENSMUSP00000107271
Gene: ENSMUSG00000001630
AA Change: Y450*

DomainStartEndE-ValueType
S_TKc 90 383 5.62e-100 SMART
S_TK_X 384 452 3.66e-1 SMART
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous gene-trapped mice exhibit premature dendritic branching of CA3 pyramidal neurons. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd6 G T 1: 155,587,458 A135S probably benign Het
Agbl4 A G 4: 111,566,698 K307R possibly damaging Het
AI481877 A G 4: 59,047,543 W1359R probably benign Het
Akna T C 4: 63,381,846 E653G possibly damaging Het
Arhgap26 T C 18: 39,121,888 Y273H probably damaging Het
Atg14 G A 14: 47,568,199 R70C probably damaging Het
Atp1a1 C T 3: 101,591,127 V250M possibly damaging Het
Cacna1c T G 6: 118,742,361 D215A probably damaging Het
Cadps T A 14: 12,822,345 N132Y probably damaging Het
Casp6 T C 3: 129,910,555 F97L possibly damaging Het
Ckap2l T C 2: 129,285,370 N296S possibly damaging Het
Col6a4 T C 9: 106,074,867 K611E probably benign Het
Copa A G 1: 172,113,108 H696R probably damaging Het
Cyp2a4 T A 7: 26,312,204 N283K probably benign Het
Dcc C T 18: 71,378,738 V869I probably benign Het
Efemp1 G T 11: 28,867,868 G116C probably damaging Het
F830045P16Rik T C 2: 129,460,553 E373G probably benign Het
Fbxo9 T C 9: 78,086,279 T318A probably benign Het
Gipr A G 7: 19,157,544 W403R probably damaging Het
Gm10093 A G 17: 78,492,758 S393G probably benign Het
Gm12794 T A 4: 101,941,151 D106E possibly damaging Het
Gm4787 G C 12: 81,377,830 T518S probably benign Het
Golgb1 G A 16: 36,875,616 probably benign Het
Herc3 T C 6: 58,856,641 L171P probably damaging Het
Il5ra A G 6: 106,738,134 I221T probably benign Het
Itgb2 A G 10: 77,564,667 I705V probably damaging Het
Map4k4 G T 1: 39,962,217 V55F probably damaging Het
Mast1 A G 8: 84,913,318 probably null Het
Mitf G T 6: 97,994,430 G186V probably benign Het
Mtpn C T 6: 35,512,290 D100N probably benign Het
Nrcam T C 12: 44,544,784 F204L probably damaging Het
Olfr1 AGCGGTCGTAGGC AGC 11: 73,395,654 probably null Het
Olfr1111 T C 2: 87,150,449 I71V probably benign Het
Olfr1510 A G 14: 52,410,218 L218P probably damaging Het
Olfr248 A G 1: 174,391,200 M44V probably benign Het
Olfr381 A T 11: 73,486,389 V145E probably damaging Het
Olfr446 T C 6: 42,927,437 S69P probably benign Het
Olfr503 A T 7: 108,545,404 N291I probably damaging Het
Pclo A T 5: 14,676,249 probably benign Het
Pik3ca T A 3: 32,450,053 Y631N probably damaging Het
Ptk2b T C 14: 66,172,517 D462G probably benign Het
Rnf19a A G 15: 36,247,778 S427P probably damaging Het
Scn3a T A 2: 65,469,034 Y1376F possibly damaging Het
Spem1 A G 11: 69,820,927 Y304H probably damaging Het
Stx19 A G 16: 62,821,974 E51G probably damaging Het
Ttc41 C G 10: 86,776,579 Q1239E probably benign Het
Tuba3a C T 6: 125,281,340 R229H probably damaging Het
Utp18 A T 11: 93,876,089 V264D probably damaging Het
V1rd19 T C 7: 24,003,289 V60A probably damaging Het
Virma T G 4: 11,494,819 V40G probably damaging Het
Vmn1r160 C T 7: 22,871,290 Q23* probably null Het
Vmn2r13 T C 5: 109,191,939 I57V probably benign Het
Vmn2r26 T A 6: 124,061,873 F802L probably damaging Het
Vmn2r61 A G 7: 42,260,222 D57G probably benign Het
Vps13c A G 9: 67,878,131 N260S probably damaging Het
Xirp1 C A 9: 120,019,602 A72S probably damaging Het
Zfp212 T C 6: 47,929,077 V190A probably benign Het
Zfp703 C T 8: 26,979,205 P299L probably damaging Het
Other mutations in Stk38l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Stk38l APN 6 146758473 start codon destroyed probably null 0.05
IGL00976:Stk38l APN 6 146775402 missense probably benign 0.37
IGL01607:Stk38l APN 6 146771654 missense probably damaging 0.99
IGL01607:Stk38l APN 6 146772227 splice site probably benign
IGL02552:Stk38l APN 6 146767533 missense probably damaging 1.00
IGL02582:Stk38l APN 6 146766823 critical splice donor site probably null
IGL03036:Stk38l APN 6 146768874 missense probably damaging 1.00
R0445:Stk38l UTSW 6 146775686 missense probably benign
R1518:Stk38l UTSW 6 146771631 missense probably benign 0.09
R2117:Stk38l UTSW 6 146768846 missense probably damaging 1.00
R5602:Stk38l UTSW 6 146758500 missense probably benign 0.39
R5652:Stk38l UTSW 6 146773328 missense possibly damaging 0.91
R6830:Stk38l UTSW 6 146766771 missense possibly damaging 0.88
R7572:Stk38l UTSW 6 146775654 missense probably damaging 1.00
R8028:Stk38l UTSW 6 146773383 missense probably damaging 1.00
R8120:Stk38l UTSW 6 146758601 missense probably benign
R8142:Stk38l UTSW 6 146758572 missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- TGATGACTTCCCTGAGTCTGATATC -3'
(R):5'- AGCAGCCTCAGATTCCCAAG -3'

Sequencing Primer
(F):5'- CTGAGTCTGATATCTTACAGCCAGG -3'
(R):5'- AGATTCCCAAGCTGTAGTCG -3'
Posted On2016-07-22