Incidental Mutation 'R5297:Vmn2r61'
| ID |
405484 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
EG637873, Casr-rs2, Gprc2a-rs2 |
| MMRRC Submission |
042880-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
R5297 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
42260053-42300755 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 42260222 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 57
(D57G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166131
AA Change: D57G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: D57G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206486
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 58 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acbd6 |
G |
T |
1: 155,587,458 (GRCm38) |
A135S |
probably benign |
Het |
| Agbl4 |
A |
G |
4: 111,566,698 (GRCm38) |
K307R |
possibly damaging |
Het |
| AI481877 |
A |
G |
4: 59,047,543 (GRCm38) |
W1359R |
probably benign |
Het |
| Akna |
T |
C |
4: 63,381,846 (GRCm38) |
E653G |
possibly damaging |
Het |
| Arhgap26 |
T |
C |
18: 39,121,888 (GRCm38) |
Y273H |
probably damaging |
Het |
| Atg14 |
G |
A |
14: 47,568,199 (GRCm38) |
R70C |
probably damaging |
Het |
| Atp1a1 |
C |
T |
3: 101,591,127 (GRCm38) |
V250M |
possibly damaging |
Het |
| Cacna1c |
T |
G |
6: 118,742,361 (GRCm38) |
D215A |
probably damaging |
Het |
| Cadps |
T |
A |
14: 12,822,345 (GRCm38) |
N132Y |
probably damaging |
Het |
| Casp6 |
T |
C |
3: 129,910,555 (GRCm38) |
F97L |
possibly damaging |
Het |
| Ckap2l |
T |
C |
2: 129,285,370 (GRCm38) |
N296S |
possibly damaging |
Het |
| Col6a4 |
T |
C |
9: 106,074,867 (GRCm38) |
K611E |
probably benign |
Het |
| Copa |
A |
G |
1: 172,113,108 (GRCm38) |
H696R |
probably damaging |
Het |
| Cyp2a4 |
T |
A |
7: 26,312,204 (GRCm38) |
N283K |
probably benign |
Het |
| Dcc |
C |
T |
18: 71,378,738 (GRCm38) |
V869I |
probably benign |
Het |
| Efemp1 |
G |
T |
11: 28,867,868 (GRCm38) |
G116C |
probably damaging |
Het |
| F830045P16Rik |
T |
C |
2: 129,460,553 (GRCm38) |
E373G |
probably benign |
Het |
| Fbxo9 |
T |
C |
9: 78,086,279 (GRCm38) |
T318A |
probably benign |
Het |
| Gipr |
A |
G |
7: 19,157,544 (GRCm38) |
W403R |
probably damaging |
Het |
| Gm10093 |
A |
G |
17: 78,492,758 (GRCm38) |
S393G |
probably benign |
Het |
| Gm12794 |
T |
A |
4: 101,941,151 (GRCm38) |
D106E |
possibly damaging |
Het |
| Gm4787 |
G |
C |
12: 81,377,830 (GRCm38) |
T518S |
probably benign |
Het |
| Golgb1 |
G |
A |
16: 36,875,616 (GRCm38) |
|
probably benign |
Het |
| Herc3 |
T |
C |
6: 58,856,641 (GRCm38) |
L171P |
probably damaging |
Het |
| Il5ra |
A |
G |
6: 106,738,134 (GRCm38) |
I221T |
probably benign |
Het |
| Itgb2 |
A |
G |
10: 77,564,667 (GRCm38) |
I705V |
probably damaging |
Het |
| Map4k4 |
G |
T |
1: 39,962,217 (GRCm38) |
V55F |
probably damaging |
Het |
| Mast1 |
A |
G |
8: 84,913,318 (GRCm38) |
|
probably null |
Het |
| Mitf |
G |
T |
6: 97,994,430 (GRCm38) |
G186V |
probably benign |
Het |
| Mtpn |
C |
T |
6: 35,512,290 (GRCm38) |
D100N |
probably benign |
Het |
| Nrcam |
T |
C |
12: 44,544,784 (GRCm38) |
F204L |
probably damaging |
Het |
| Olfr1 |
AGCGGTCGTAGGC |
AGC |
11: 73,395,654 (GRCm38) |
|
probably null |
Het |
| Olfr1111 |
T |
C |
2: 87,150,449 (GRCm38) |
I71V |
probably benign |
Het |
| Olfr1510 |
A |
G |
14: 52,410,218 (GRCm38) |
L218P |
probably damaging |
Het |
| Olfr248 |
A |
G |
1: 174,391,200 (GRCm38) |
M44V |
probably benign |
Het |
| Olfr381 |
A |
T |
11: 73,486,389 (GRCm38) |
V145E |
probably damaging |
Het |
| Olfr446 |
T |
C |
6: 42,927,437 (GRCm38) |
S69P |
probably benign |
Het |
| Olfr503 |
A |
T |
7: 108,545,404 (GRCm38) |
N291I |
probably damaging |
Het |
| Pclo |
A |
T |
5: 14,676,249 (GRCm38) |
|
probably benign |
Het |
| Pik3ca |
T |
A |
3: 32,450,053 (GRCm38) |
Y631N |
probably damaging |
Het |
| Ptk2b |
T |
C |
14: 66,172,517 (GRCm38) |
D462G |
probably benign |
Het |
| Rnf19a |
A |
G |
15: 36,247,778 (GRCm38) |
S427P |
probably damaging |
Het |
| Scn3a |
T |
A |
2: 65,469,034 (GRCm38) |
Y1376F |
possibly damaging |
Het |
| Spem1 |
A |
G |
11: 69,820,927 (GRCm38) |
Y304H |
probably damaging |
Het |
| Stk38l |
C |
A |
6: 146,775,655 (GRCm38) |
Y450* |
probably null |
Het |
| Stx19 |
A |
G |
16: 62,821,974 (GRCm38) |
E51G |
probably damaging |
Het |
| Ttc41 |
C |
G |
10: 86,776,579 (GRCm38) |
Q1239E |
probably benign |
Het |
| Tuba3a |
C |
T |
6: 125,281,340 (GRCm38) |
R229H |
probably damaging |
Het |
| Utp18 |
A |
T |
11: 93,876,089 (GRCm38) |
V264D |
probably damaging |
Het |
| V1rd19 |
T |
C |
7: 24,003,289 (GRCm38) |
V60A |
probably damaging |
Het |
| Virma |
T |
G |
4: 11,494,819 (GRCm38) |
V40G |
probably damaging |
Het |
| Vmn1r160 |
C |
T |
7: 22,871,290 (GRCm38) |
Q23* |
probably null |
Het |
| Vmn2r13 |
T |
C |
5: 109,191,939 (GRCm38) |
I57V |
probably benign |
Het |
| Vmn2r26 |
T |
A |
6: 124,061,873 (GRCm38) |
F802L |
probably damaging |
Het |
| Vps13c |
A |
G |
9: 67,878,131 (GRCm38) |
N260S |
probably damaging |
Het |
| Xirp1 |
C |
A |
9: 120,019,602 (GRCm38) |
A72S |
probably damaging |
Het |
| Zfp212 |
T |
C |
6: 47,929,077 (GRCm38) |
V190A |
probably benign |
Het |
| Zfp703 |
C |
T |
8: 26,979,205 (GRCm38) |
P299L |
probably damaging |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
42,300,751 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
42,267,014 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
42,300,511 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
42,260,126 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
42,266,834 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
42,260,237 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
42,300,706 (GRCm38) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
42,300,591 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
42,260,215 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
42,300,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
42,300,042 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
42,276,734 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
42,276,646 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
42,275,468 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
42,299,937 (GRCm38) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
42,265,984 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
42,267,085 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
42,260,093 (GRCm38) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
42,260,255 (GRCm38) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
42,275,474 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
42,300,517 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
42,265,911 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
42,266,018 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
42,300,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
42,300,511 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
42,300,697 (GRCm38) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
42,266,652 (GRCm38) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
42,300,286 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
42,300,001 (GRCm38) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
42,266,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
42,300,105 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
42,266,643 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
42,267,067 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
42,300,735 (GRCm38) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
42,300,733 (GRCm38) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
42,300,696 (GRCm38) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
42,267,141 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
42,267,035 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
42,300,708 (GRCm38) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
42,267,096 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
42,300,054 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
42,300,529 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5497:Vmn2r61
|
UTSW |
7 |
42,275,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
42,266,818 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
42,300,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
42,300,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
42,267,253 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
42,299,829 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
42,267,031 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
42,260,192 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
42,266,491 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
42,299,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
42,267,235 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
42,265,859 (GRCm38) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
42,276,715 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
42,300,156 (GRCm38) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
42,300,324 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
42,299,979 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
42,299,940 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
42,267,133 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
42,267,205 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
42,260,110 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
42,265,983 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
42,266,781 (GRCm38) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
42,267,048 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
42,266,673 (GRCm38) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
42,266,608 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
42,300,511 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
42,266,717 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
42,266,656 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
42,300,276 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
42,266,770 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
42,300,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
42,265,901 (GRCm38) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
42,265,961 (GRCm38) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
42,300,668 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
42,267,195 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
42,300,169 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
42,267,202 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
42,276,712 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9729:Vmn2r61
|
UTSW |
7 |
42,300,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
42,299,964 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
42,266,742 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
42,260,161 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGGGCAGGTGTATACATTAATAG -3'
(R):5'- TCTGGTGTTACATGCATGACAAAG -3'
Sequencing Primer
(F):5'- AGGATGTTCTGGATTTTTACCTATGG -3'
(R):5'- CCTTTTACAGAGGAAAAGAAGTCAAC -3'
|
| Posted On |
2016-07-22 |
Incidental Mutation