Incidental Mutation 'R5316:Or8s5'
ID 405851
Institutional Source Beutler Lab
Gene Symbol Or8s5
Ensembl Gene ENSMUSG00000051793
Gene Name olfactory receptor family 8 subfamily S member 5
Synonyms Olfr284, MOR160-4, GA_x6K02T2NBG7-5395976-5396893
MMRRC Submission 042899-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5316 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 98237903-98238820 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 98238246 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 208 (A208V)
Ref Sequence ENSEMBL: ENSMUSP00000145864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063289] [ENSMUST00000206647]
AlphaFold A0A0U1RP76
Predicted Effect probably benign
Transcript: ENSMUST00000063289
AA Change: A192V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000065626
Gene: ENSMUSG00000051793
AA Change: A192V

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 5.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 33 259 1.3e-5 PFAM
Pfam:7tm_1 39 286 5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206647
AA Change: A208V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b G A 12: 113,455,013 (GRCm39) R610H probably damaging Het
Agap2 G A 10: 126,918,296 (GRCm39) probably null Het
Apol10a A G 15: 77,372,729 (GRCm39) T122A probably damaging Het
Arhgap17 G T 7: 122,895,750 (GRCm39) A458D possibly damaging Het
Cd80 C T 16: 38,294,239 (GRCm39) Q41* probably null Het
Cmss1 T G 16: 57,122,638 (GRCm39) K252T probably damaging Het
Cog2 A G 8: 125,255,779 (GRCm39) D122G probably benign Het
Dsc3 T A 18: 20,096,598 (GRCm39) D841V possibly damaging Het
Dst C A 1: 34,262,929 (GRCm39) Q4549K probably damaging Het
Efcab3 A G 11: 104,967,286 (GRCm39) I5275M possibly damaging Het
Epha6 A G 16: 59,775,083 (GRCm39) L711P probably damaging Het
Gabrg2 T A 11: 41,867,385 (GRCm39) N78I probably damaging Het
H1f1 C T 13: 23,948,085 (GRCm39) probably benign Het
Htra3 T C 5: 35,821,420 (GRCm39) D319G probably damaging Het
Jph1 T C 1: 17,161,750 (GRCm39) Y304C probably damaging Het
Kat2a G T 11: 100,602,996 (GRCm39) Q79K possibly damaging Het
Klhl7 C T 5: 24,332,748 (GRCm39) A102V probably benign Het
Lamb3 A G 1: 193,012,501 (GRCm39) H426R probably benign Het
Lemd3 C A 10: 120,788,161 (GRCm39) probably null Het
Mcm3ap A C 10: 76,306,760 (GRCm39) D291A possibly damaging Het
Micos13 G A 17: 56,916,649 (GRCm39) S7L possibly damaging Het
Mme C G 3: 63,276,375 (GRCm39) F717L probably damaging Het
Mybpc2 T A 7: 44,169,806 (GRCm39) K171* probably null Het
Naip6 T C 13: 100,420,290 (GRCm39) N1327D probably benign Het
Nr2e1 A T 10: 42,447,487 (GRCm39) M175K probably benign Het
Or8a1b A T 9: 37,622,981 (GRCm39) V198D possibly damaging Het
Ppef2 A T 5: 92,383,670 (GRCm39) M480K probably benign Het
Prkar2b A T 12: 32,110,984 (GRCm39) L33Q probably damaging Het
Ralgps2 A T 1: 156,641,067 (GRCm39) V496E probably damaging Het
Rbms2 G A 10: 127,981,606 (GRCm39) P81L probably damaging Het
Scara5 T C 14: 65,927,264 (GRCm39) S54P possibly damaging Het
Slc18a3 T C 14: 32,184,814 (GRCm39) D523G probably benign Het
Sntb1 C G 15: 55,506,191 (GRCm39) G461R probably damaging Het
Srrt C A 5: 137,294,813 (GRCm39) A747S probably benign Het
Sycp2 C T 2: 177,998,296 (GRCm39) D1075N probably benign Het
Tasor A G 14: 27,193,992 (GRCm39) D1064G possibly damaging Het
Vat1l G A 8: 115,011,088 (GRCm39) V279I probably damaging Het
Zfp677 A G 17: 21,617,410 (GRCm39) K156E probably damaging Het
Other mutations in Or8s5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Or8s5 APN 15 98,238,054 (GRCm39) missense possibly damaging 0.47
IGL02904:Or8s5 APN 15 98,238,729 (GRCm39) missense probably null 0.88
PIT4378001:Or8s5 UTSW 15 98,238,153 (GRCm39) missense possibly damaging 0.95
R0485:Or8s5 UTSW 15 98,238,810 (GRCm39) missense probably benign 0.01
R1435:Or8s5 UTSW 15 98,238,209 (GRCm39) missense possibly damaging 0.69
R4706:Or8s5 UTSW 15 98,238,659 (GRCm39) missense possibly damaging 0.62
R4707:Or8s5 UTSW 15 98,238,659 (GRCm39) missense possibly damaging 0.62
R5272:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5314:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5315:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5317:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5456:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5458:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5548:Or8s5 UTSW 15 98,238,253 (GRCm39) missense probably benign 0.21
R5717:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5921:Or8s5 UTSW 15 98,238,310 (GRCm39) missense probably benign 0.10
R6519:Or8s5 UTSW 15 98,237,929 (GRCm39) missense probably benign 0.00
R6636:Or8s5 UTSW 15 98,238,831 (GRCm39) missense probably benign 0.23
R7112:Or8s5 UTSW 15 98,238,421 (GRCm39) missense possibly damaging 0.81
R7289:Or8s5 UTSW 15 98,237,943 (GRCm39) missense probably damaging 1.00
R7392:Or8s5 UTSW 15 98,238,192 (GRCm39) missense probably benign 0.03
R7403:Or8s5 UTSW 15 98,238,000 (GRCm39) missense probably damaging 1.00
R7633:Or8s5 UTSW 15 98,237,967 (GRCm39) missense probably damaging 1.00
R7724:Or8s5 UTSW 15 98,238,775 (GRCm39) missense possibly damaging 0.89
R9451:Or8s5 UTSW 15 98,238,144 (GRCm39) missense possibly damaging 0.61
R9707:Or8s5 UTSW 15 98,238,154 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCGGTAAGAGATAACTGATAAACCC -3'
(R):5'- TTGCTCTACAGCCAGGTGATG -3'

Sequencing Primer
(F):5'- GAGATAACTGATAAACCCCGAGC -3'
(R):5'- CTCTACAGCCAGGTGATGAGTAGC -3'
Posted On 2016-07-22