Incidental Mutation 'R5320:Or13a27'
ID 406050
Institutional Source Beutler Lab
Gene Symbol Or13a27
Ensembl Gene ENSMUSG00000060112
Gene Name olfactory receptor family 13 subfamily A member 27
Synonyms MOR253-6, Olfr60, GA_x6K02T2PBJ9-42496183-42495251, IH6
MMRRC Submission 042903-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R5320 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 139924965-139925900 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 139925548 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 118 (V118A)
Ref Sequence ENSEMBL: ENSMUSP00000150685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075470] [ENSMUST00000210932] [ENSMUST00000211031] [ENSMUST00000215023] [ENSMUST00000216027]
AlphaFold Q8VGL4
Predicted Effect probably benign
Transcript: ENSMUST00000075470
AA Change: V118A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000074916
Gene: ENSMUSG00000060112
AA Change: V118A

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 1.2e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 161 1.8e-8 PFAM
Pfam:7tm_1 42 291 2e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209726
Predicted Effect probably benign
Transcript: ENSMUST00000210932
AA Change: V118A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000211031
AA Change: V118A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211655
Predicted Effect probably benign
Transcript: ENSMUST00000215023
AA Change: V118A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000216027
AA Change: V118A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A T 17: 24,526,541 (GRCm39) I581N probably damaging Het
Abcb10 A G 8: 124,697,763 (GRCm39) F187S probably benign Het
Actl11 T A 9: 107,808,203 (GRCm39) V842E possibly damaging Het
Akap12 A G 10: 4,307,291 (GRCm39) D1367G probably benign Het
Aoc1l1 T A 6: 48,952,474 (GRCm39) L133Q probably damaging Het
Aoc1l3 T A 6: 48,964,509 (GRCm39) F172L probably benign Het
AU040320 A T 4: 126,717,509 (GRCm39) H362L possibly damaging Het
Bmpr1a C T 14: 34,146,999 (GRCm39) V258M probably damaging Het
Bptf T A 11: 106,972,193 (GRCm39) K892* probably null Het
Cap2 A G 13: 46,801,840 (GRCm39) *422W probably null Het
Cars2 G T 8: 11,567,854 (GRCm39) H414N probably benign Het
Ccnt1 A C 15: 98,442,124 (GRCm39) S381R probably benign Het
Cdyl2 A T 8: 117,321,794 (GRCm39) C244* probably null Het
Cers2 A G 3: 95,228,305 (GRCm39) E115G probably null Het
Cpt1b G A 15: 89,303,477 (GRCm39) P553S probably benign Het
Cuedc1 A G 11: 88,068,136 (GRCm39) E128G probably damaging Het
Dll4 T A 2: 119,156,968 (GRCm39) V80D probably damaging Het
Dop1b T C 16: 93,536,874 (GRCm39) L113P probably damaging Het
Fam98a A G 17: 75,845,810 (GRCm39) I312T probably damaging Het
Gnrhr T G 5: 86,345,473 (GRCm39) K71T possibly damaging Het
Gtf3c3 A T 1: 54,445,032 (GRCm39) L674Q probably damaging Het
Hipk2 A T 6: 38,795,212 (GRCm39) H352Q probably damaging Het
Hivep1 T C 13: 42,313,115 (GRCm39) V1785A probably damaging Het
Hspa4 A T 11: 53,153,810 (GRCm39) I687N probably damaging Het
Krt18 A T 15: 101,936,955 (GRCm39) D81V probably damaging Het
Lama3 A C 18: 12,685,912 (GRCm39) D1142A probably damaging Het
Lnpep A G 17: 17,766,727 (GRCm39) I713T possibly damaging Het
Man2b2 T A 5: 36,967,677 (GRCm39) Y897F probably damaging Het
Muc5b A T 7: 141,412,738 (GRCm39) I1895F unknown Het
Myh8 G A 11: 67,177,089 (GRCm39) V414I probably damaging Het
Myo1d A T 11: 80,575,149 (GRCm39) probably null Het
Nav2 A T 7: 49,141,121 (GRCm39) M889L probably benign Het
Oc90 C T 15: 65,754,457 (GRCm39) G236D probably benign Het
Pak4 A G 7: 28,267,631 (GRCm39) I11T probably damaging Het
Papss2 T C 19: 32,615,787 (GRCm39) I173T probably damaging Het
Pcsk9 A T 4: 106,320,988 (GRCm39) D40E probably benign Het
Pdzrn3 G C 6: 101,128,064 (GRCm39) H867Q probably damaging Het
Plcb1 A T 2: 135,094,696 (GRCm39) I174F possibly damaging Het
Pom121l2 G A 13: 22,166,015 (GRCm39) W95* probably null Het
Prcp A T 7: 92,577,843 (GRCm39) T336S probably benign Het
Prdm11 A C 2: 92,843,226 (GRCm39) S78A probably benign Het
Ralgds T C 2: 28,435,224 (GRCm39) I405T probably damaging Het
Rasgrf1 A G 9: 89,902,478 (GRCm39) R1208G probably damaging Het
Rasgrp2 T A 19: 6,458,864 (GRCm39) probably null Het
Rb1 A T 14: 73,450,566 (GRCm39) Y599* probably null Het
Rnf141 A T 7: 110,433,010 (GRCm39) F62L probably damaging Het
Rsl24d1 T A 9: 73,023,698 (GRCm39) F292I possibly damaging Het
Scn10a C T 9: 119,477,175 (GRCm39) V736I probably damaging Het
Sim2 A T 16: 93,905,598 (GRCm39) T141S probably benign Het
Slc6a15 G T 10: 103,244,067 (GRCm39) V436L probably damaging Het
Smarca2 T C 19: 26,668,772 (GRCm39) S924P probably damaging Het
Tacc1 T C 8: 25,671,881 (GRCm39) E449G probably benign Het
Tlr3 A T 8: 45,852,137 (GRCm39) N253K possibly damaging Het
Tmem198 G A 1: 75,456,500 (GRCm39) A82T probably benign Het
Tom1l2 A T 11: 60,133,648 (GRCm39) L54* probably null Het
Trav12-2 A G 14: 53,854,356 (GRCm39) Y110C probably benign Het
Trdn T A 10: 33,209,247 (GRCm39) probably null Het
Trim36 G T 18: 46,300,565 (GRCm39) P690Q probably damaging Het
Trpc4 A T 3: 54,206,599 (GRCm39) M600L probably damaging Het
Trpm2 T A 10: 77,759,355 (GRCm39) Q1143L probably benign Het
Usp34 T A 11: 23,283,739 (GRCm39) D144E probably benign Het
Vps18 A T 2: 119,127,858 (GRCm39) R894* probably null Het
Vwa1 A G 4: 155,855,369 (GRCm39) V248A probably benign Het
Wdr75 T C 1: 45,838,211 (GRCm39) V40A probably damaging Het
Other mutations in Or13a27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Or13a27 APN 7 139,925,123 (GRCm39) missense probably damaging 1.00
IGL03493:Or13a27 APN 7 139,925,066 (GRCm39) missense probably damaging 1.00
R0413:Or13a27 UTSW 7 139,925,108 (GRCm39) missense possibly damaging 0.94
R0652:Or13a27 UTSW 7 139,925,545 (GRCm39) missense probably damaging 1.00
R1848:Or13a27 UTSW 7 139,925,900 (GRCm39) start codon destroyed probably benign
R1908:Or13a27 UTSW 7 139,925,378 (GRCm39) missense probably benign 0.05
R1909:Or13a27 UTSW 7 139,925,378 (GRCm39) missense probably benign 0.05
R5133:Or13a27 UTSW 7 139,925,236 (GRCm39) missense probably damaging 1.00
R5429:Or13a27 UTSW 7 139,925,186 (GRCm39) missense possibly damaging 0.67
R6595:Or13a27 UTSW 7 139,925,560 (GRCm39) missense probably damaging 1.00
R6621:Or13a27 UTSW 7 139,925,368 (GRCm39) missense probably damaging 1.00
R7300:Or13a27 UTSW 7 139,925,268 (GRCm39) missense probably damaging 1.00
R7409:Or13a27 UTSW 7 139,925,318 (GRCm39) missense probably benign 0.00
R7562:Or13a27 UTSW 7 139,925,143 (GRCm39) missense probably damaging 1.00
R7646:Or13a27 UTSW 7 139,925,864 (GRCm39) missense probably damaging 1.00
R8158:Or13a27 UTSW 7 139,925,162 (GRCm39) missense probably benign 0.03
R8233:Or13a27 UTSW 7 139,925,411 (GRCm39) missense probably benign 0.01
R8238:Or13a27 UTSW 7 139,925,803 (GRCm39) missense probably damaging 1.00
R8338:Or13a27 UTSW 7 139,925,306 (GRCm39) missense probably benign 0.00
R9794:Or13a27 UTSW 7 139,925,483 (GRCm39) nonsense probably null
Z1088:Or13a27 UTSW 7 139,925,717 (GRCm39) missense probably benign 0.42
Predicted Primers PCR Primer
(F):5'- GACCTTGGGTCCACAGAATG -3'
(R):5'- TGGGCAACATTTTGATCATTGC -3'

Sequencing Primer
(F):5'- CTTGGGTCCACAGAATGACAGC -3'
(R):5'- TTGGTCACCTTCAGCACTGGG -3'
Posted On 2016-07-22