Mutagenetix > Incidental Mutation

Incidental Mutation 'R5321:Vmn2r10'

406103

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r10

Ensembl Gene

ENSMUSG00000067010

Gene Name

vomeronasal 2, receptor 10

Synonyms

VR16, V2r16

MMRRC Submission

042904-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R5321 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109141278-109154337 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 109143505 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Glutamic Acid at position 815 (A815E)

Ref Sequence

ENSEMBL: ENSMUSP00000078162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]

AlphaFold

K7N621

Predicted Effect

probably damaging
Transcript: ENSMUST00000079163
AA Change: A815E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: A815E

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	8.5e-29	PFAM
Pfam:NCD3G	506	560	3.8e-17	PFAM
Pfam:7tm_3	593	828	4e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176594

SMART Domains

Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.7%
20x: 96.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	A	G	11: 110,218,651 (GRCm39)	F72L	probably benign	Het
Btrc	G	A	19: 45,496,197 (GRCm39)	V211M	probably damaging	Het
Col6a5	A	T	9: 105,805,664 (GRCm39)	Y1081N	unknown	Het
Cryzl1	T	C	16: 91,504,118 (GRCm39)	Y109C	probably benign	Het
Dlec1	T	A	9: 118,941,669 (GRCm39)	S352T	probably benign	Het
Dzip3	T	G	16: 48,778,038 (GRCm39)	T349P	possibly damaging	Het
Endou	A	G	15: 97,618,913 (GRCm39)	V37A	probably damaging	Het
Exosc1	A	T	19: 41,912,499 (GRCm39)	C129*	probably null	Het
Flywch1	C	G	17: 23,975,625 (GRCm39)	R539P	probably damaging	Het
Gm14410	G	A	2: 176,885,298 (GRCm39)	T322I	probably damaging	Het
Lcor	G	T	19: 41,573,643 (GRCm39)	W799C	probably damaging	Het
Lpin2	G	A	17: 71,553,853 (GRCm39)	V857M	probably damaging	Het
Or52ae9	T	C	7: 103,389,862 (GRCm39)	N195S	probably damaging	Het
Patl1	A	G	19: 11,898,785 (GRCm39)	Q160R	probably damaging	Het
Phtf1	C	T	3: 103,910,827 (GRCm39)	T606I	probably benign	Het
Polr3a	T	C	14: 24,505,009 (GRCm39)	I1084V	possibly damaging	Het
Scrt1	T	C	15: 76,403,370 (GRCm39)	S207G	unknown	Het
Slc15a5	G	T	6: 137,964,436 (GRCm39)	N496K	probably benign	Het
Slc34a1	A	T	13: 23,996,614 (GRCm39)	I40F	possibly damaging	Het
Tdrd12	A	C	7: 35,177,519 (GRCm39)	V945G	probably damaging	Het
Tdrkh	C	A	3: 94,332,965 (GRCm39)	L169I	probably damaging	Het
Tmem59l	A	G	8: 70,939,865 (GRCm39)	C35R	probably damaging	Het
Tpte	A	T	8: 22,787,219 (GRCm39)	R33*	probably null	Het
Trpv2	T	A	11: 62,475,397 (GRCm39)	L270H	probably damaging	Het
Utp18	A	G	11: 93,757,260 (GRCm39)	L468P	probably damaging	Het
Uxs1	A	G	1: 43,844,805 (GRCm39)	I51T	probably damaging	Het
Vmn1r20	C	T	6: 57,409,427 (GRCm39)	S251L	probably benign	Het
Vmn1r24	A	T	6: 57,933,182 (GRCm39)	L112*	probably null	Het
Vmn1r5	T	C	6: 56,962,592 (GRCm39)	L89P	probably damaging	Het
Zfp119a	A	T	17: 56,172,595 (GRCm39)	L416H	probably damaging	Het

Other mutations in Vmn2r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Vmn2r10	APN	5	109,150,451 (GRCm39)	missense	possibly damaging	0.75
IGL01618:Vmn2r10	APN	5	109,150,345 (GRCm39)	missense	probably damaging	1.00
IGL01624:Vmn2r10	APN	5	109,154,112 (GRCm39)	missense	possibly damaging	0.83
IGL01941:Vmn2r10	APN	5	109,143,820 (GRCm39)	missense	probably damaging	1.00
IGL01959:Vmn2r10	APN	5	109,145,571 (GRCm39)	missense	probably benign	0.00
IGL01973:Vmn2r10	APN	5	109,143,543 (GRCm39)	missense	probably damaging	1.00
IGL01985:Vmn2r10	APN	5	109,154,125 (GRCm39)	missense	probably benign	0.21
IGL02451:Vmn2r10	APN	5	109,143,788 (GRCm39)	nonsense	probably null
IGL02503:Vmn2r10	APN	5	109,151,341 (GRCm39)	missense	probably damaging	1.00
IGL03275:Vmn2r10	APN	5	109,151,243 (GRCm39)	missense	probably benign	0.00
R0035:Vmn2r10	UTSW	5	109,145,467 (GRCm39)	splice site	probably benign
R0395:Vmn2r10	UTSW	5	109,149,859 (GRCm39)	missense	probably damaging	1.00
R0454:Vmn2r10	UTSW	5	109,151,327 (GRCm39)	missense	probably benign	0.25
R0648:Vmn2r10	UTSW	5	109,143,782 (GRCm39)	missense	probably benign	0.00
R1251:Vmn2r10	UTSW	5	109,143,890 (GRCm39)	missense	probably benign	0.01
R1580:Vmn2r10	UTSW	5	109,154,117 (GRCm39)	missense	possibly damaging	0.82
R1845:Vmn2r10	UTSW	5	109,149,861 (GRCm39)	nonsense	probably null
R1986:Vmn2r10	UTSW	5	109,154,120 (GRCm39)	nonsense	probably null
R2137:Vmn2r10	UTSW	5	109,151,410 (GRCm39)	missense	possibly damaging	0.87
R2495:Vmn2r10	UTSW	5	109,143,961 (GRCm39)	missense	probably damaging	1.00
R3932:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R3933:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R4899:Vmn2r10	UTSW	5	109,151,324 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r10	UTSW	5	109,145,592 (GRCm39)	missense	possibly damaging	0.89
R5124:Vmn2r10	UTSW	5	109,154,286 (GRCm39)	missense	probably benign	0.01
R5145:Vmn2r10	UTSW	5	109,143,761 (GRCm39)	missense	possibly damaging	0.64
R5156:Vmn2r10	UTSW	5	109,143,466 (GRCm39)	missense	probably benign	0.11
R5265:Vmn2r10	UTSW	5	109,143,586 (GRCm39)	missense	probably damaging	1.00
R5311:Vmn2r10	UTSW	5	109,154,121 (GRCm39)	missense	probably damaging	1.00
R5666:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5670:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5872:Vmn2r10	UTSW	5	109,151,377 (GRCm39)	missense	possibly damaging	0.84
R6004:Vmn2r10	UTSW	5	109,146,944 (GRCm39)	missense	probably benign	0.30
R6108:Vmn2r10	UTSW	5	109,143,667 (GRCm39)	missense	probably damaging	1.00
R6332:Vmn2r10	UTSW	5	109,151,328 (GRCm39)	missense	probably damaging	1.00
R6599:Vmn2r10	UTSW	5	109,143,944 (GRCm39)	missense	probably benign	0.09
R6651:Vmn2r10	UTSW	5	109,143,488 (GRCm39)	missense	probably null	0.22
R6891:Vmn2r10	UTSW	5	109,149,845 (GRCm39)	missense	probably damaging	1.00
R7023:Vmn2r10	UTSW	5	109,149,894 (GRCm39)	missense	probably damaging	0.96
R7146:Vmn2r10	UTSW	5	109,151,200 (GRCm39)	missense	probably damaging	1.00
R7941:Vmn2r10	UTSW	5	109,144,306 (GRCm39)	missense	probably damaging	1.00
R8058:Vmn2r10	UTSW	5	109,149,955 (GRCm39)	missense	probably benign	0.00
R8478:Vmn2r10	UTSW	5	109,143,636 (GRCm39)	missense	probably damaging	1.00
R8526:Vmn2r10	UTSW	5	109,145,572 (GRCm39)	missense	possibly damaging	0.51
R8698:Vmn2r10	UTSW	5	109,151,390 (GRCm39)	missense	probably benign	0.00
R8796:Vmn2r10	UTSW	5	109,143,917 (GRCm39)	missense	possibly damaging	0.74
R8854:Vmn2r10	UTSW	5	109,144,126 (GRCm39)	missense	probably benign	0.20
R8871:Vmn2r10	UTSW	5	109,146,899 (GRCm39)	missense	possibly damaging	0.67
R8893:Vmn2r10	UTSW	5	109,143,677 (GRCm39)	missense	probably benign	0.09
R8907:Vmn2r10	UTSW	5	109,149,791 (GRCm39)	missense	probably benign
R8957:Vmn2r10	UTSW	5	109,149,780 (GRCm39)	missense	possibly damaging	0.60
R8976:Vmn2r10	UTSW	5	109,145,479 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r10	UTSW	5	109,144,212 (GRCm39)	missense	probably benign	0.10
R9308:Vmn2r10	UTSW	5	109,145,476 (GRCm39)	nonsense	probably null
R9800:Vmn2r10	UTSW	5	109,150,404 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r10	UTSW	5	109,143,979 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r10	UTSW	5	109,149,854 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTGCTGCCCTACATTGTAAATAC -3'
(R):5'- TGGCTTTCTTGGCTAGGAAC -3'

Sequencing Primer
(F):5'- TTTTGTATGATTTAGTGGTGCTTTTG -3'
(R):5'- GGAACCTTCCTGACAGATTCAATG -3'

Posted On

2016-07-22