Mutagenetix > Incidental Mutation

Incidental Mutation 'R5321:Vmn1r24'

406107

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r24

Ensembl Gene

ENSMUSG00000115507

Gene Name

vomeronasal 1 receptor 24

Synonyms

V1rc18

MMRRC Submission

042904-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.253) question?

Stock #

R5321 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57932626-57933516 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 57933182 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 112 (L112*)

Ref Sequence

ENSEMBL: ENSMUSP00000153775 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000175716] [ENSMUST00000228097] [ENSMUST00000228315]

AlphaFold

Q8R2D6

Predicted Effect

probably null
Transcript: ENSMUST00000175716
AA Change: L112*

SMART Domains

Protein: ENSMUSP00000134939
Gene: ENSMUSG00000093451
AA Change: L112*

Domain	Start	End	E-Value	Type
Pfam:V1R	29	293	8.2e-55	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000228097
AA Change: L112*

Predicted Effect

probably null
Transcript: ENSMUST00000228315
AA Change: L112*

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.7%
20x: 96.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	A	G	11: 110,218,651 (GRCm39)	F72L	probably benign	Het
Btrc	G	A	19: 45,496,197 (GRCm39)	V211M	probably damaging	Het
Col6a5	A	T	9: 105,805,664 (GRCm39)	Y1081N	unknown	Het
Cryzl1	T	C	16: 91,504,118 (GRCm39)	Y109C	probably benign	Het
Dlec1	T	A	9: 118,941,669 (GRCm39)	S352T	probably benign	Het
Dzip3	T	G	16: 48,778,038 (GRCm39)	T349P	possibly damaging	Het
Endou	A	G	15: 97,618,913 (GRCm39)	V37A	probably damaging	Het
Exosc1	A	T	19: 41,912,499 (GRCm39)	C129*	probably null	Het
Flywch1	C	G	17: 23,975,625 (GRCm39)	R539P	probably damaging	Het
Gm14410	G	A	2: 176,885,298 (GRCm39)	T322I	probably damaging	Het
Lcor	G	T	19: 41,573,643 (GRCm39)	W799C	probably damaging	Het
Lpin2	G	A	17: 71,553,853 (GRCm39)	V857M	probably damaging	Het
Or52ae9	T	C	7: 103,389,862 (GRCm39)	N195S	probably damaging	Het
Patl1	A	G	19: 11,898,785 (GRCm39)	Q160R	probably damaging	Het
Phtf1	C	T	3: 103,910,827 (GRCm39)	T606I	probably benign	Het
Polr3a	T	C	14: 24,505,009 (GRCm39)	I1084V	possibly damaging	Het
Scrt1	T	C	15: 76,403,370 (GRCm39)	S207G	unknown	Het
Slc15a5	G	T	6: 137,964,436 (GRCm39)	N496K	probably benign	Het
Slc34a1	A	T	13: 23,996,614 (GRCm39)	I40F	possibly damaging	Het
Tdrd12	A	C	7: 35,177,519 (GRCm39)	V945G	probably damaging	Het
Tdrkh	C	A	3: 94,332,965 (GRCm39)	L169I	probably damaging	Het
Tmem59l	A	G	8: 70,939,865 (GRCm39)	C35R	probably damaging	Het
Tpte	A	T	8: 22,787,219 (GRCm39)	R33*	probably null	Het
Trpv2	T	A	11: 62,475,397 (GRCm39)	L270H	probably damaging	Het
Utp18	A	G	11: 93,757,260 (GRCm39)	L468P	probably damaging	Het
Uxs1	A	G	1: 43,844,805 (GRCm39)	I51T	probably damaging	Het
Vmn1r20	C	T	6: 57,409,427 (GRCm39)	S251L	probably benign	Het
Vmn1r5	T	C	6: 56,962,592 (GRCm39)	L89P	probably damaging	Het
Vmn2r10	G	T	5: 109,143,505 (GRCm39)	A815E	probably damaging	Het
Zfp119a	A	T	17: 56,172,595 (GRCm39)	L416H	probably damaging	Het

Other mutations in Vmn1r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0064:Vmn1r24	UTSW	6	57,933,003 (GRCm39)	missense	probably benign	0.03
R1707:Vmn1r24	UTSW	6	57,933,497 (GRCm39)	missense	probably benign	0.02
R2079:Vmn1r24	UTSW	6	57,932,655 (GRCm39)	missense	probably benign	0.10
R4867:Vmn1r24	UTSW	6	57,933,421 (GRCm39)	missense	probably damaging	0.96
R6954:Vmn1r24	UTSW	6	57,933,437 (GRCm39)	missense	probably benign	0.00
R8787:Vmn1r24	UTSW	6	57,932,958 (GRCm39)	missense	probably benign	0.22
R9254:Vmn1r24	UTSW	6	57,932,736 (GRCm39)	missense	probably benign	0.01
R9499:Vmn1r24	UTSW	6	57,933,150 (GRCm39)	missense	possibly damaging	0.88
R9711:Vmn1r24	UTSW	6	57,932,804 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTTCATGGGAAAGTGTGAGC -3'
(R):5'- CTAAGCCTGTGGACCTGATCTC -3'

Sequencing Primer
(F):5'- GCAGTAATTAGTGACCTTCATCTGGC -3'
(R):5'- CACATAATTATGGTCCTCACTGGATG -3'

Posted On

2016-07-22