Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02875:Vmn2r42'

406180

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r42

Ensembl Gene

ENSMUSG00000070844

Gene Name

vomeronasal 2, receptor 42

Synonyms

V2r4

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02875

Quality Score

Status

Chromosome

Chromosomal Location

8186264-8203319 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 8197852 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 256 (T256A)

Ref Sequence

ENSEMBL: ENSMUSP00000123451 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086282] [ENSMUST00000142934] [ENSMUST00000146278]

AlphaFold

O35192

Predicted Effect

probably benign
Transcript: ENSMUST00000086282
AA Change: T256A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000083463
Gene: ENSMUSG00000070844
AA Change: T256A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
low complexity region	59	71	N/A	INTRINSIC
Pfam:ANF_receptor	73	470	1.6e-33	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	2.8e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129936

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136957

Predicted Effect

probably benign
Transcript: ENSMUST00000142934
AA Change: T256A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000123451
Gene: ENSMUSG00000070844
AA Change: T256A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
low complexity region	59	71	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	7.4e-34	PFAM
Pfam:NCD3G	512	563	4.2e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000146278
AA Change: T256A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000119761
Gene: ENSMUSG00000070844
AA Change: T256A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
low complexity region	59	71	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1.9e-33	PFAM
Pfam:NCD3G	512	565	6.7e-17	PFAM
Pfam:7tm_3	548	784	2e-78	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	C	2: 69,122,293 (GRCm39)	I397V	possibly damaging	Het
Asph	A	G	4: 9,595,380 (GRCm39)	S281P	probably damaging	Het
Bdnf	T	C	2: 109,554,196 (GRCm39)	V150A	probably damaging	Het
Birc6	T	C	17: 74,896,713 (GRCm39)	V1053A	probably damaging	Het
Btg4	T	A	9: 51,030,446 (GRCm39)	F182Y	probably benign	Het
Casc3	T	G	11: 98,712,378 (GRCm39)	V139G	probably damaging	Het
Ccno	C	A	13: 113,124,586 (GRCm39)	P52Q	possibly damaging	Het
Cdk1	T	G	10: 69,178,366 (GRCm39)		probably benign	Het
Daam2	A	C	17: 49,771,056 (GRCm39)	I887S	probably damaging	Het
Dmrta1	A	G	4: 89,579,985 (GRCm39)	D315G	possibly damaging	Het
Dnah6	T	C	6: 73,115,698 (GRCm39)	I1515V	probably damaging	Het
Dock7	A	T	4: 98,864,231 (GRCm39)	I1241K	probably benign	Het
Fam180a	T	C	6: 35,290,617 (GRCm39)	D122G	probably damaging	Het
Gm11992	C	T	11: 9,002,887 (GRCm39)		probably benign	Het
Il1b	A	G	2: 129,209,171 (GRCm39)	I153T	probably benign	Het
Kntc1	C	A	5: 123,916,340 (GRCm39)		probably null	Het
Krt77	T	C	15: 101,777,584 (GRCm39)	D157G	probably damaging	Het
Lmbr1	A	G	5: 29,497,186 (GRCm39)	S72P	probably damaging	Het
Mphosph9	T	A	5: 124,421,800 (GRCm39)		probably null	Het
Mpp4	C	T	1: 59,175,993 (GRCm39)		probably null	Het
Ncbp2	T	A	16: 31,772,971 (GRCm39)	L36Q	probably damaging	Het
Or2b7	T	A	13: 21,740,172 (GRCm39)	S7C	probably damaging	Het
Or4a72	T	C	2: 89,405,896 (GRCm39)	Y58C	probably damaging	Het
Or8b3	A	G	9: 38,314,472 (GRCm39)	M101V	probably damaging	Het
Oscp1	A	G	4: 125,970,601 (GRCm39)	D130G	probably damaging	Het
Pls1	A	T	9: 95,636,404 (GRCm39)	M615K	possibly damaging	Het
Prep	C	A	10: 45,034,529 (GRCm39)	H680Q	probably damaging	Het
Rad1	T	C	15: 10,493,365 (GRCm39)	I264T	probably benign	Het
Rhbdf1	A	G	11: 32,163,293 (GRCm39)	V393A	possibly damaging	Het
Skint3	A	T	4: 112,113,079 (GRCm39)	I230L	possibly damaging	Het
Slc9b1	T	A	3: 135,080,167 (GRCm39)		probably benign	Het
Slfn3	T	C	11: 83,104,253 (GRCm39)	Y375H	probably damaging	Het
Ssrp1	T	A	2: 84,871,264 (GRCm39)	I257N	probably damaging	Het
Svep1	A	G	4: 58,082,821 (GRCm39)		probably benign	Het
Tcl1b2	T	C	12: 105,120,358 (GRCm39)	*118Q	probably null	Het
Thsd7b	A	G	1: 129,879,130 (GRCm39)	Y989C	probably damaging	Het
Trim58	C	T	11: 58,531,292 (GRCm39)		probably benign	Het

Other mutations in Vmn2r42

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02444:Vmn2r42	APN	7	8,187,312 (GRCm39)	missense	probably damaging	0.99
IGL02793:Vmn2r42	APN	7	8,197,852 (GRCm39)	missense	probably benign	0.00
R1743:Vmn2r42	UTSW	7	8,187,264 (GRCm39)	missense	probably benign	0.06
R3943:Vmn2r42	UTSW	7	8,197,779 (GRCm39)	missense	possibly damaging	0.93
R4117:Vmn2r42	UTSW	7	8,197,839 (GRCm39)	missense	probably damaging	1.00
R4760:Vmn2r42	UTSW	7	8,187,276 (GRCm39)	missense	probably damaging	1.00
R5233:Vmn2r42	UTSW	7	8,197,837 (GRCm39)	nonsense	probably null
R6245:Vmn2r42	UTSW	7	8,195,733 (GRCm39)	missense	probably damaging	1.00
R6683:Vmn2r42	UTSW	7	8,187,224 (GRCm39)	missense	probably damaging	0.98
R6709:Vmn2r42	UTSW	7	8,195,618 (GRCm39)	missense	probably benign	0.09
R7396:Vmn2r42	UTSW	7	8,195,641 (GRCm39)	missense	probably benign	0.00
R7450:Vmn2r42	UTSW	7	8,187,220 (GRCm39)	missense	probably benign	0.00
R7583:Vmn2r42	UTSW	7	8,197,740 (GRCm39)	nonsense	probably null
R7973:Vmn2r42	UTSW	7	8,197,872 (GRCm39)	missense	probably benign	0.03
R8777:Vmn2r42	UTSW	7	8,195,692 (GRCm39)	missense	probably benign	0.14
R8777-TAIL:Vmn2r42	UTSW	7	8,195,692 (GRCm39)	missense	probably benign	0.14
R8900:Vmn2r42	UTSW	7	8,197,792 (GRCm39)	missense	probably benign	0.15
R8972:Vmn2r42	UTSW	7	8,187,331 (GRCm39)	missense	probably damaging	1.00
R9335:Vmn2r42	UTSW	7	8,197,758 (GRCm39)	missense	probably damaging	0.99
R9453:Vmn2r42	UTSW	7	8,187,295 (GRCm39)	missense	probably benign	0.39

Posted On

2016-08-02