Incidental Mutation 'IGL02974:Olfr1449'
ID406260
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1449
Ensembl Gene ENSMUSG00000049498
Gene Nameolfactory receptor 1449
SynonymsGA_x6K02T2RE5P-3264213-3265157, MOR202-34
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02974
Quality Score
Status
Chromosome19
Chromosomal Location12930840-12935752 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 12935035 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glycine at position 99 (V99G)
Ref Sequence ENSEMBL: ENSMUSP00000148934 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056005] [ENSMUST00000208624] [ENSMUST00000214079] [ENSMUST00000215325]
Predicted Effect probably benign
Transcript: ENSMUST00000056005
AA Change: V99G

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000056181
Gene: ENSMUSG00000049498
AA Change: V99G

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 4.5e-53 PFAM
Pfam:7tm_1 42 290 3.7e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208624
AA Change: V99G

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000214079
AA Change: V99G

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000215325
AA Change: V99G

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730480H06Rik C T 5: 48,388,137 T242M probably damaging Het
Abcg3 A T 5: 104,968,263 I235N probably damaging Het
Agbl3 T C 6: 34,799,822 L416S probably damaging Het
Alcam T C 16: 52,295,716 D165G probably benign Het
Aldh18a1 T A 19: 40,569,084 I341F probably damaging Het
Amn T C 12: 111,271,141 V7A probably benign Het
Apc C T 18: 34,268,383 probably benign Het
Arg2 T C 12: 79,150,792 Y195H probably damaging Het
Bdp1 A T 13: 100,055,292 M22K probably benign Het
Cacna1s T G 1: 136,092,617 N797K possibly damaging Het
Chd8 T A 14: 52,201,701 probably null Het
Clstn2 G A 9: 97,532,707 T378M probably damaging Het
Elf2 A G 3: 51,257,689 V298A probably damaging Het
Fbn1 C T 2: 125,346,330 D1530N probably null Het
Fcrls A T 3: 87,257,397 I274N possibly damaging Het
Fmo3 C T 1: 162,983,050 E24K probably damaging Het
Fndc3b A T 3: 27,488,276 N408K probably damaging Het
Foxn2 A T 17: 88,463,115 N130I probably damaging Het
Fscb T A 12: 64,471,525 I1056F unknown Het
Gimap5 A C 6: 48,753,377 T294P possibly damaging Het
Gm20489 T C X: 101,263,714 Q11R probably damaging Het
Gpr3 T C 4: 133,210,909 T151A possibly damaging Het
Gzmc T A 14: 56,233,994 H30L probably damaging Het
Ints6l C A X: 56,506,936 S845Y probably benign Het
Iqcf3 A T 9: 106,553,645 C101* probably null Het
Krt82 G A 15: 101,550,585 Q7* probably null Het
L3mbtl1 A T 2: 162,970,183 H716L possibly damaging Het
Lefty1 C A 1: 180,935,277 H56Q probably benign Het
Lrp1 T C 10: 127,555,016 Y3004C probably damaging Het
Lrp10 C A 14: 54,467,884 S177* probably null Het
Naa15 A G 3: 51,461,207 K576R possibly damaging Het
Naip2 A G 13: 100,161,678 S617P probably damaging Het
Olfm1 T G 2: 28,229,689 N445K probably damaging Het
Olfr1187-ps1 C T 2: 88,540,235 silent Het
Ostm1 T A 10: 42,683,162 N139K probably damaging Het
Ovol1 A G 19: 5,551,149 Y205H probably damaging Het
Pappa C T 4: 65,204,935 L836F probably damaging Het
Pcdhb15 C A 18: 37,475,014 T433N probably damaging Het
Ppfia2 A G 10: 106,800,776 K229E probably benign Het
Ppm1b T A 17: 84,993,824 V44E possibly damaging Het
Rapgef1 T C 2: 29,710,216 F611L possibly damaging Het
Rev3l T A 10: 39,862,747 Y2832* probably null Het
Robo1 T A 16: 73,006,862 Y1099N probably benign Het
Sf3b1 T C 1: 55,007,707 H226R probably benign Het
Slc26a4 C T 12: 31,529,554 V570I probably damaging Het
Slc27a1 C A 8: 71,584,203 A361D probably damaging Het
Srp68 T C 11: 116,246,225 N549D probably benign Het
Terb1 G T 8: 104,494,968 S202* probably null Het
Tmc1 T A 19: 20,900,844 M96L probably benign Het
Tmprss11d A G 5: 86,306,376 V190A probably damaging Het
Ttll6 G A 11: 96,156,702 C709Y probably benign Het
Uba1 A G X: 20,678,720 H712R probably benign Het
Unc80 A C 1: 66,525,658 T835P possibly damaging Het
Vmn2r14 G A 5: 109,221,426 P94S possibly damaging Het
Yes1 C T 5: 32,660,768 A383V probably damaging Het
Other mutations in Olfr1449
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01674:Olfr1449 APN 19 12935562 missense probably damaging 0.98
IGL01943:Olfr1449 APN 19 12935674 missense probably benign 0.24
IGL02966:Olfr1449 APN 19 12934800 missense probably benign 0.08
IGL03220:Olfr1449 APN 19 12935494 missense probably damaging 1.00
PIT4531001:Olfr1449 UTSW 19 12935277 missense probably damaging 0.98
R0285:Olfr1449 UTSW 19 12935172 missense probably benign 0.00
R0573:Olfr1449 UTSW 19 12935260 missense possibly damaging 0.77
R0588:Olfr1449 UTSW 19 12934747 missense probably benign 0.00
R0726:Olfr1449 UTSW 19 12935605 missense probably damaging 1.00
R1006:Olfr1449 UTSW 19 12935274 missense probably damaging 1.00
R1146:Olfr1449 UTSW 19 12934965 missense possibly damaging 0.77
R1146:Olfr1449 UTSW 19 12934965 missense possibly damaging 0.77
R1386:Olfr1449 UTSW 19 12935139 missense probably benign 0.17
R1735:Olfr1449 UTSW 19 12934843 missense probably damaging 1.00
R1794:Olfr1449 UTSW 19 12934968 missense probably damaging 0.97
R2355:Olfr1449 UTSW 19 12935019 missense possibly damaging 0.91
R2511:Olfr1449 UTSW 19 12935173 missense possibly damaging 0.85
R4673:Olfr1449 UTSW 19 12935097 missense probably damaging 1.00
R4749:Olfr1449 UTSW 19 12935217 missense probably benign 0.02
R4765:Olfr1449 UTSW 19 12935076 missense possibly damaging 0.65
R5112:Olfr1449 UTSW 19 12934816 missense probably benign 0.01
R5958:Olfr1449 UTSW 19 12935047 missense probably damaging 1.00
R6115:Olfr1449 UTSW 19 12935584 missense possibly damaging 0.54
R6152:Olfr1449 UTSW 19 12935487 missense probably benign 0.13
R6417:Olfr1449 UTSW 19 12935220 missense probably damaging 1.00
R6420:Olfr1449 UTSW 19 12935220 missense probably damaging 1.00
R6695:Olfr1449 UTSW 19 12935400 missense possibly damaging 0.95
R6963:Olfr1449 UTSW 19 12935638 missense probably damaging 0.96
Posted On2016-08-02