Incidental Mutation 'IGL02975:Vmn2r66'
ID 406321
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r66
Ensembl Gene ENSMUSG00000094950
Gene Name vomeronasal 2, receptor 66
Synonyms F830104D24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL02975
Quality Score
Status
Chromosome 7
Chromosomal Location 84643853-84661228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84656182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 278 (L278P)
Ref Sequence ENSEMBL: ENSMUSP00000122645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124773]
AlphaFold A0A3B2W842
Predicted Effect probably damaging
Transcript: ENSMUST00000124773
AA Change: L278P

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: L278P

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 463 5e-31 PFAM
Pfam:NCD3G 507 559 6e-21 PFAM
Pfam:7tm_3 589 827 3.8e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik T C 5: 99,381,784 (GRCm39) D326G possibly damaging Het
Abtb3 A G 10: 85,467,207 (GRCm39) I721V probably benign Het
Ago4 C T 4: 126,406,312 (GRCm39) probably null Het
Ank A G 15: 27,467,087 (GRCm39) probably benign Het
Ankmy2 C A 12: 36,243,773 (GRCm39) S329R possibly damaging Het
Aox1 A G 1: 58,107,550 (GRCm39) E608G probably damaging Het
Car1 G A 3: 14,842,882 (GRCm39) L48F probably benign Het
Cct8 A G 16: 87,283,118 (GRCm39) probably benign Het
Clasp1 A T 1: 118,390,277 (GRCm39) T154S probably damaging Het
Clca4a A C 3: 144,669,530 (GRCm39) I340M possibly damaging Het
Cnksr3 C T 10: 7,088,354 (GRCm39) probably null Het
Cntrob T C 11: 69,210,199 (GRCm39) T265A possibly damaging Het
Ddx5 T C 11: 106,672,711 (GRCm39) I605V probably benign Het
Eif3i A G 4: 129,489,105 (GRCm39) Y70H probably damaging Het
Epb41l5 T C 1: 119,506,811 (GRCm39) probably benign Het
Fah A T 7: 84,250,287 (GRCm39) S90T probably benign Het
Fat2 T A 11: 55,161,020 (GRCm39) M3237L probably benign Het
Fbxw8 A G 5: 118,215,760 (GRCm39) Y417H probably benign Het
Fmnl2 C A 2: 52,991,494 (GRCm39) F336L probably benign Het
Gli3 A G 13: 15,899,153 (GRCm39) R847G probably damaging Het
Gm17509 T C 13: 117,357,308 (GRCm39) probably benign Het
Gm4846 T A 1: 166,311,449 (GRCm39) Y470F possibly damaging Het
Gm7461 T C 8: 4,727,847 (GRCm39) noncoding transcript Het
Gpatch4 A T 3: 87,961,743 (GRCm39) N134I possibly damaging Het
Grina A G 15: 76,133,185 (GRCm39) Y251C probably damaging Het
Gsn A G 2: 35,194,666 (GRCm39) D654G probably benign Het
Hyal5 A G 6: 24,891,451 (GRCm39) T422A probably benign Het
Iars1 T A 13: 49,858,325 (GRCm39) I377N probably damaging Het
Ints3 A T 3: 90,309,144 (GRCm39) probably benign Het
Kdm4b G A 17: 56,682,996 (GRCm39) probably null Het
Kyat1 A G 2: 30,076,687 (GRCm39) S276P probably damaging Het
Lrrc1 A G 9: 77,359,929 (GRCm39) C288R probably damaging Het
Mst1r T A 9: 107,790,379 (GRCm39) M664K probably benign Het
Neb A T 2: 52,188,879 (GRCm39) I817N probably damaging Het
Nudt6 C A 3: 37,473,667 (GRCm39) G18V probably damaging Het
Or10a49 G A 7: 108,468,062 (GRCm39) Q100* probably null Het
Or4k52 T A 2: 111,611,266 (GRCm39) Y200* probably null Het
Or7a41 T C 10: 78,870,867 (GRCm39) V79A possibly damaging Het
Pde1c A G 6: 56,135,921 (GRCm39) I341T probably damaging Het
Pgm5 T C 19: 24,812,212 (GRCm39) I107V probably benign Het
Pot1b G A 17: 55,969,454 (GRCm39) probably benign Het
Prkca C T 11: 108,231,503 (GRCm39) W58* probably null Het
Slc12a9 T C 5: 137,320,705 (GRCm39) K555R probably damaging Het
Smoc2 A T 17: 14,556,872 (GRCm39) Q107L probably damaging Het
Sytl1 T A 4: 132,988,343 (GRCm39) R4S probably benign Het
Tbc1d4 A G 14: 101,695,549 (GRCm39) L963P probably damaging Het
Tfdp2 G A 9: 96,199,989 (GRCm39) probably benign Het
Tmem63a A T 1: 180,788,640 (GRCm39) M326L probably benign Het
Wtap A G 17: 13,202,398 (GRCm39) V11A possibly damaging Het
Zcchc9 A T 13: 91,954,172 (GRCm39) S28T possibly damaging Het
Zfp12 C T 5: 143,229,814 (GRCm39) probably benign Het
Other mutations in Vmn2r66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Vmn2r66 APN 7 84,656,299 (GRCm39) missense probably benign
IGL01562:Vmn2r66 APN 7 84,656,495 (GRCm39) missense probably benign 0.03
IGL01689:Vmn2r66 APN 7 84,657,033 (GRCm39) missense probably damaging 1.00
IGL02237:Vmn2r66 APN 7 84,643,908 (GRCm39) missense probably benign
IGL02415:Vmn2r66 APN 7 84,656,020 (GRCm39) missense probably damaging 0.97
IGL02439:Vmn2r66 APN 7 84,654,455 (GRCm39) splice site probably benign
IGL02545:Vmn2r66 APN 7 84,655,798 (GRCm39) missense possibly damaging 0.50
IGL02708:Vmn2r66 APN 7 84,655,796 (GRCm39) missense probably benign 0.00
IGL02794:Vmn2r66 APN 7 84,644,623 (GRCm39) missense probably benign 0.00
IGL02885:Vmn2r66 APN 7 84,644,723 (GRCm39) missense probably benign 0.00
IGL03027:Vmn2r66 APN 7 84,644,777 (GRCm39) splice site probably benign
IGL03081:Vmn2r66 APN 7 84,657,138 (GRCm39) missense probably benign
PIT4131001:Vmn2r66 UTSW 7 84,644,301 (GRCm39) missense probably damaging 1.00
R0098:Vmn2r66 UTSW 7 84,654,965 (GRCm39) missense probably damaging 1.00
R0504:Vmn2r66 UTSW 7 84,656,023 (GRCm39) missense probably damaging 0.99
R0557:Vmn2r66 UTSW 7 84,643,972 (GRCm39) missense probably damaging 1.00
R0617:Vmn2r66 UTSW 7 84,644,484 (GRCm39) missense probably benign 0.02
R0883:Vmn2r66 UTSW 7 84,657,070 (GRCm39) missense probably benign
R1159:Vmn2r66 UTSW 7 84,644,613 (GRCm39) missense probably benign 0.44
R1168:Vmn2r66 UTSW 7 84,656,062 (GRCm39) missense possibly damaging 0.46
R1172:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1175:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1538:Vmn2r66 UTSW 7 84,644,166 (GRCm39) missense possibly damaging 0.84
R1658:Vmn2r66 UTSW 7 84,656,955 (GRCm39) missense probably benign 0.07
R1937:Vmn2r66 UTSW 7 84,644,344 (GRCm39) missense probably damaging 0.99
R1989:Vmn2r66 UTSW 7 84,661,201 (GRCm39) missense probably benign 0.01
R2698:Vmn2r66 UTSW 7 84,644,607 (GRCm39) missense probably damaging 1.00
R2890:Vmn2r66 UTSW 7 84,661,027 (GRCm39) splice site probably null
R3686:Vmn2r66 UTSW 7 84,644,397 (GRCm39) missense probably damaging 0.96
R4152:Vmn2r66 UTSW 7 84,654,800 (GRCm39) missense probably benign 0.08
R4500:Vmn2r66 UTSW 7 84,657,162 (GRCm39) missense probably damaging 1.00
R4618:Vmn2r66 UTSW 7 84,644,296 (GRCm39) missense possibly damaging 0.62
R4656:Vmn2r66 UTSW 7 84,661,204 (GRCm39) missense possibly damaging 0.87
R4668:Vmn2r66 UTSW 7 84,643,905 (GRCm39) missense probably damaging 1.00
R4942:Vmn2r66 UTSW 7 84,656,980 (GRCm39) missense probably damaging 1.00
R5163:Vmn2r66 UTSW 7 84,656,017 (GRCm39) missense probably benign 0.01
R5223:Vmn2r66 UTSW 7 84,657,093 (GRCm39) missense probably benign
R5377:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R5512:Vmn2r66 UTSW 7 84,657,149 (GRCm39) missense probably damaging 1.00
R5611:Vmn2r66 UTSW 7 84,654,951 (GRCm39) nonsense probably null
R5749:Vmn2r66 UTSW 7 84,655,979 (GRCm39) nonsense probably null
R6131:Vmn2r66 UTSW 7 84,644,224 (GRCm39) missense probably damaging 1.00
R6183:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R6509:Vmn2r66 UTSW 7 84,656,054 (GRCm39) missense probably benign 0.12
R6930:Vmn2r66 UTSW 7 84,661,216 (GRCm39) missense possibly damaging 0.80
R6992:Vmn2r66 UTSW 7 84,654,436 (GRCm39) missense possibly damaging 0.90
R7015:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R7302:Vmn2r66 UTSW 7 84,654,423 (GRCm39) missense probably benign 0.00
R7516:Vmn2r66 UTSW 7 84,661,176 (GRCm39) missense possibly damaging 0.51
R7763:Vmn2r66 UTSW 7 84,654,909 (GRCm39) missense probably benign 0.01
R7814:Vmn2r66 UTSW 7 84,656,472 (GRCm39) missense probably benign 0.02
R8077:Vmn2r66 UTSW 7 84,656,093 (GRCm39) missense probably benign
R8307:Vmn2r66 UTSW 7 84,656,270 (GRCm39) missense probably benign
R8315:Vmn2r66 UTSW 7 84,643,932 (GRCm39) missense possibly damaging 0.90
R8490:Vmn2r66 UTSW 7 84,654,794 (GRCm39) critical splice donor site probably null
R8511:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R8781:Vmn2r66 UTSW 7 84,644,355 (GRCm39) nonsense probably null
R8812:Vmn2r66 UTSW 7 84,654,893 (GRCm39) missense probably damaging 0.99
R9203:Vmn2r66 UTSW 7 84,654,950 (GRCm39) missense probably benign 0.01
R9277:Vmn2r66 UTSW 7 84,661,164 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02