Incidental Mutation 'IGL02975:Ints3'
ID 406361
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ints3
Ensembl Gene ENSMUSG00000027933
Gene Name integrator complex subunit 3
Synonyms
Accession Numbers
Essential gene? Probably essential (E-score: 0.969) question?
Stock # IGL02975
Quality Score
Status
Chromosome 3
Chromosomal Location 90298695-90340929 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 90309144 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143196 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029542] [ENSMUST00000071488] [ENSMUST00000196530]
AlphaFold Q7TPD0
Predicted Effect probably benign
Transcript: ENSMUST00000029542
SMART Domains Protein: ENSMUSP00000029542
Gene: ENSMUSG00000027933

DomainStartEndE-ValueType
low complexity region 11 33 N/A INTRINSIC
Pfam:DUF2356 269 493 6e-110 PFAM
low complexity region 557 568 N/A INTRINSIC
low complexity region 632 647 N/A INTRINSIC
low complexity region 666 678 N/A INTRINSIC
coiled coil region 913 940 N/A INTRINSIC
low complexity region 1006 1019 N/A INTRINSIC
low complexity region 1021 1031 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000071488
SMART Domains Protein: ENSMUSP00000071422
Gene: ENSMUSG00000027933

DomainStartEndE-ValueType
low complexity region 11 33 N/A INTRINSIC
Pfam:DUF2356 269 493 6e-110 PFAM
low complexity region 557 568 N/A INTRINSIC
low complexity region 632 647 N/A INTRINSIC
low complexity region 666 678 N/A INTRINSIC
coiled coil region 913 940 N/A INTRINSIC
low complexity region 1006 1019 N/A INTRINSIC
low complexity region 1021 1031 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196530
SMART Domains Protein: ENSMUSP00000143196
Gene: ENSMUSG00000027933

DomainStartEndE-ValueType
low complexity region 11 33 N/A INTRINSIC
Pfam:DUF2356 268 497 5.7e-114 PFAM
low complexity region 557 568 N/A INTRINSIC
low complexity region 632 647 N/A INTRINSIC
low complexity region 666 678 N/A INTRINSIC
coiled coil region 913 940 N/A INTRINSIC
low complexity region 1006 1018 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198776
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199992
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik T C 5: 99,381,784 (GRCm39) D326G possibly damaging Het
Abtb3 A G 10: 85,467,207 (GRCm39) I721V probably benign Het
Ago4 C T 4: 126,406,312 (GRCm39) probably null Het
Ank A G 15: 27,467,087 (GRCm39) probably benign Het
Ankmy2 C A 12: 36,243,773 (GRCm39) S329R possibly damaging Het
Aox1 A G 1: 58,107,550 (GRCm39) E608G probably damaging Het
Car1 G A 3: 14,842,882 (GRCm39) L48F probably benign Het
Cct8 A G 16: 87,283,118 (GRCm39) probably benign Het
Clasp1 A T 1: 118,390,277 (GRCm39) T154S probably damaging Het
Clca4a A C 3: 144,669,530 (GRCm39) I340M possibly damaging Het
Cnksr3 C T 10: 7,088,354 (GRCm39) probably null Het
Cntrob T C 11: 69,210,199 (GRCm39) T265A possibly damaging Het
Ddx5 T C 11: 106,672,711 (GRCm39) I605V probably benign Het
Eif3i A G 4: 129,489,105 (GRCm39) Y70H probably damaging Het
Epb41l5 T C 1: 119,506,811 (GRCm39) probably benign Het
Fah A T 7: 84,250,287 (GRCm39) S90T probably benign Het
Fat2 T A 11: 55,161,020 (GRCm39) M3237L probably benign Het
Fbxw8 A G 5: 118,215,760 (GRCm39) Y417H probably benign Het
Fmnl2 C A 2: 52,991,494 (GRCm39) F336L probably benign Het
Gli3 A G 13: 15,899,153 (GRCm39) R847G probably damaging Het
Gm17509 T C 13: 117,357,308 (GRCm39) probably benign Het
Gm4846 T A 1: 166,311,449 (GRCm39) Y470F possibly damaging Het
Gm7461 T C 8: 4,727,847 (GRCm39) noncoding transcript Het
Gpatch4 A T 3: 87,961,743 (GRCm39) N134I possibly damaging Het
Grina A G 15: 76,133,185 (GRCm39) Y251C probably damaging Het
Gsn A G 2: 35,194,666 (GRCm39) D654G probably benign Het
Hyal5 A G 6: 24,891,451 (GRCm39) T422A probably benign Het
Iars1 T A 13: 49,858,325 (GRCm39) I377N probably damaging Het
Kdm4b G A 17: 56,682,996 (GRCm39) probably null Het
Kyat1 A G 2: 30,076,687 (GRCm39) S276P probably damaging Het
Lrrc1 A G 9: 77,359,929 (GRCm39) C288R probably damaging Het
Mst1r T A 9: 107,790,379 (GRCm39) M664K probably benign Het
Neb A T 2: 52,188,879 (GRCm39) I817N probably damaging Het
Nudt6 C A 3: 37,473,667 (GRCm39) G18V probably damaging Het
Or10a49 G A 7: 108,468,062 (GRCm39) Q100* probably null Het
Or4k52 T A 2: 111,611,266 (GRCm39) Y200* probably null Het
Or7a41 T C 10: 78,870,867 (GRCm39) V79A possibly damaging Het
Pde1c A G 6: 56,135,921 (GRCm39) I341T probably damaging Het
Pgm5 T C 19: 24,812,212 (GRCm39) I107V probably benign Het
Pot1b G A 17: 55,969,454 (GRCm39) probably benign Het
Prkca C T 11: 108,231,503 (GRCm39) W58* probably null Het
Slc12a9 T C 5: 137,320,705 (GRCm39) K555R probably damaging Het
Smoc2 A T 17: 14,556,872 (GRCm39) Q107L probably damaging Het
Sytl1 T A 4: 132,988,343 (GRCm39) R4S probably benign Het
Tbc1d4 A G 14: 101,695,549 (GRCm39) L963P probably damaging Het
Tfdp2 G A 9: 96,199,989 (GRCm39) probably benign Het
Tmem63a A T 1: 180,788,640 (GRCm39) M326L probably benign Het
Vmn2r66 A G 7: 84,656,182 (GRCm39) L278P probably damaging Het
Wtap A G 17: 13,202,398 (GRCm39) V11A possibly damaging Het
Zcchc9 A T 13: 91,954,172 (GRCm39) S28T possibly damaging Het
Zfp12 C T 5: 143,229,814 (GRCm39) probably benign Het
Other mutations in Ints3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Ints3 APN 3 90,313,636 (GRCm39) missense probably damaging 1.00
IGL01339:Ints3 APN 3 90,322,463 (GRCm39) critical splice donor site probably null
IGL01398:Ints3 APN 3 90,300,130 (GRCm39) missense probably damaging 1.00
IGL01599:Ints3 APN 3 90,301,629 (GRCm39) critical splice donor site probably null
IGL01864:Ints3 APN 3 90,322,486 (GRCm39) missense probably benign 0.33
IGL01984:Ints3 APN 3 90,299,533 (GRCm39) missense possibly damaging 0.79
IGL02325:Ints3 APN 3 90,311,349 (GRCm39) missense probably damaging 1.00
IGL02516:Ints3 APN 3 90,310,415 (GRCm39) missense probably damaging 1.00
IGL02867:Ints3 APN 3 90,300,143 (GRCm39) missense probably damaging 1.00
IGL02889:Ints3 APN 3 90,300,143 (GRCm39) missense probably damaging 1.00
PIT4431001:Ints3 UTSW 3 90,303,767 (GRCm39) missense probably damaging 0.99
R0003:Ints3 UTSW 3 90,315,818 (GRCm39) missense probably benign 0.00
R0003:Ints3 UTSW 3 90,315,818 (GRCm39) missense probably benign 0.00
R0069:Ints3 UTSW 3 90,307,954 (GRCm39) splice site probably benign
R0069:Ints3 UTSW 3 90,307,954 (GRCm39) splice site probably benign
R1450:Ints3 UTSW 3 90,340,135 (GRCm39) missense probably damaging 1.00
R1985:Ints3 UTSW 3 90,307,610 (GRCm39) critical splice donor site probably null
R2324:Ints3 UTSW 3 90,301,401 (GRCm39) missense probably damaging 1.00
R2425:Ints3 UTSW 3 90,301,417 (GRCm39) missense possibly damaging 0.91
R2920:Ints3 UTSW 3 90,300,469 (GRCm39) missense probably benign 0.22
R3937:Ints3 UTSW 3 90,311,294 (GRCm39) nonsense probably null
R4678:Ints3 UTSW 3 90,315,817 (GRCm39) missense possibly damaging 0.47
R4679:Ints3 UTSW 3 90,315,817 (GRCm39) missense possibly damaging 0.47
R4719:Ints3 UTSW 3 90,322,828 (GRCm39) missense probably benign 0.20
R4726:Ints3 UTSW 3 90,301,084 (GRCm39) missense probably damaging 1.00
R4993:Ints3 UTSW 3 90,322,814 (GRCm39) missense probably benign 0.05
R5154:Ints3 UTSW 3 90,322,868 (GRCm39) missense probably benign 0.01
R5243:Ints3 UTSW 3 90,308,451 (GRCm39) frame shift probably null
R5454:Ints3 UTSW 3 90,315,834 (GRCm39) missense possibly damaging 0.72
R5678:Ints3 UTSW 3 90,310,855 (GRCm39) missense probably damaging 0.99
R6123:Ints3 UTSW 3 90,320,861 (GRCm39) missense probably benign 0.01
R6548:Ints3 UTSW 3 90,299,431 (GRCm39) unclassified probably benign
R6916:Ints3 UTSW 3 90,313,641 (GRCm39) missense probably damaging 1.00
R7265:Ints3 UTSW 3 90,311,290 (GRCm39) critical splice donor site probably null
R7332:Ints3 UTSW 3 90,322,819 (GRCm39) missense probably damaging 0.98
R7699:Ints3 UTSW 3 90,329,111 (GRCm39) missense probably benign 0.00
R7700:Ints3 UTSW 3 90,329,111 (GRCm39) missense probably benign 0.00
R7790:Ints3 UTSW 3 90,307,720 (GRCm39) missense probably benign 0.09
R7827:Ints3 UTSW 3 90,331,319 (GRCm39) missense probably benign 0.11
R7915:Ints3 UTSW 3 90,340,132 (GRCm39) missense probably benign 0.06
R8118:Ints3 UTSW 3 90,307,606 (GRCm39) splice site probably null
R8119:Ints3 UTSW 3 90,299,607 (GRCm39) missense probably damaging 0.97
R8193:Ints3 UTSW 3 90,307,929 (GRCm39) missense possibly damaging 0.82
R8468:Ints3 UTSW 3 90,313,560 (GRCm39) missense probably damaging 0.96
R9240:Ints3 UTSW 3 90,310,410 (GRCm39) missense possibly damaging 0.82
R9260:Ints3 UTSW 3 90,308,468 (GRCm39) missense probably damaging 0.99
R9486:Ints3 UTSW 3 90,313,579 (GRCm39) nonsense probably null
R9634:Ints3 UTSW 3 90,318,606 (GRCm39) missense
R9656:Ints3 UTSW 3 90,299,839 (GRCm39) missense probably null 0.01
R9744:Ints3 UTSW 3 90,318,605 (GRCm39) missense probably damaging 1.00
Z1177:Ints3 UTSW 3 90,313,663 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02