Incidental Mutation 'IGL02982:Or13a28'
ID 406567
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or13a28
Ensembl Gene ENSMUSG00000096069
Gene Name olfactory receptor family 13 subfamily A member 28
Synonyms Olfr61, IH7, GA_x6K02T2PBJ9-42783826-42784758, MOR253-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL02982
Quality Score
Status
Chromosome 7
Chromosomal Location 140217616-140218551 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 140217865 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 84 (I84F)
Ref Sequence ENSEMBL: ENSMUSP00000147924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084455] [ENSMUST00000210241] [ENSMUST00000210373] [ENSMUST00000211685]
AlphaFold Q8VGM2
Predicted Effect probably benign
Transcript: ENSMUST00000084455
AA Change: I84F

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000081493
Gene: ENSMUSG00000096069
AA Change: I84F

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 3.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 175 1.3e-8 PFAM
Pfam:7tm_1 42 291 3.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210241
AA Change: I84F

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000210373
AA Change: I25F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000211685
AA Change: I84F

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 G T 8: 25,294,447 (GRCm39) A384D probably benign Het
Adamts19 T A 18: 59,157,590 (GRCm39) C961S probably damaging Het
Agbl2 G A 2: 90,636,159 (GRCm39) C565Y probably damaging Het
Aox3 G A 1: 58,166,846 (GRCm39) E190K probably benign Het
Arf2 T G 11: 103,872,602 (GRCm39) D74E probably damaging Het
Bptf T G 11: 106,967,500 (GRCm39) D960A probably damaging Het
Ccdc180 G T 4: 45,903,840 (GRCm39) probably benign Het
Ces1a A G 8: 93,771,603 (GRCm39) F65L probably damaging Het
Def8 T C 8: 124,183,278 (GRCm39) probably benign Het
Fat4 T C 3: 38,944,992 (GRCm39) L1295P probably damaging Het
Filip1l A G 16: 57,392,595 (GRCm39) H1061R probably damaging Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
Gldc A G 19: 30,122,545 (GRCm39) probably null Het
Golgb1 A C 16: 36,746,172 (GRCm39) D2917A probably damaging Het
Gpc5 G A 14: 115,607,400 (GRCm39) C334Y probably damaging Het
Gpsm1 T A 2: 26,214,871 (GRCm39) L252Q probably damaging Het
Iars1 C T 13: 49,863,185 (GRCm39) R546C probably benign Het
Kbtbd8 G T 6: 95,103,547 (GRCm39) V399L probably benign Het
Kcnd2 A T 6: 21,217,148 (GRCm39) D284V probably damaging Het
Kcnj6 T C 16: 94,633,376 (GRCm39) K227R possibly damaging Het
Lhx9 A T 1: 138,766,349 (GRCm39) H155Q probably damaging Het
Mcm9 A G 10: 53,501,922 (GRCm39) V221A probably damaging Het
Myo9a A T 9: 59,815,491 (GRCm39) K2237* probably null Het
Ntf3 A T 6: 126,079,340 (GRCm39) D55E probably damaging Het
Or4c15b G T 2: 89,113,453 (GRCm39) T29K probably damaging Het
Plek T A 11: 16,931,826 (GRCm39) I342F probably damaging Het
Polrmt A G 10: 79,574,182 (GRCm39) Y853H probably damaging Het
Psg29 A G 7: 16,945,632 (GRCm39) T401A probably damaging Het
Ptprb A G 10: 116,158,533 (GRCm39) T822A probably benign Het
Ptprq A C 10: 107,422,545 (GRCm39) F1616V probably damaging Het
Rpe65 T A 3: 159,305,998 (GRCm39) V19E probably damaging Het
Scamp2 G A 9: 57,488,832 (GRCm39) A178T probably benign Het
Spata31e5 T C 1: 28,817,135 (GRCm39) H299R probably damaging Het
Spta1 A G 1: 174,014,854 (GRCm39) I445V probably benign Het
Tas2r135 A G 6: 42,383,187 (GRCm39) E242G probably benign Het
Ttc22 T C 4: 106,495,783 (GRCm39) V379A probably damaging Het
Unc5d C T 8: 29,142,881 (GRCm39) G857E probably damaging Het
Usp28 A G 9: 48,929,739 (GRCm39) I43V probably benign Het
Vmn2r68 A T 7: 84,883,649 (GRCm39) M152K probably benign Het
Wrn C T 8: 33,833,094 (GRCm39) G133R probably damaging Het
Zfyve26 G A 12: 79,310,644 (GRCm39) T187M probably damaging Het
Zic2 A G 14: 122,715,979 (GRCm39) E367G probably damaging Het
Other mutations in Or13a28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or13a28 APN 7 140,218,169 (GRCm39) missense probably damaging 1.00
IGL01837:Or13a28 APN 7 140,218,124 (GRCm39) missense probably damaging 1.00
IGL02349:Or13a28 APN 7 140,218,384 (GRCm39) missense probably benign 0.00
IGL02713:Or13a28 APN 7 140,217,829 (GRCm39) missense probably damaging 0.98
IGL03205:Or13a28 APN 7 140,218,073 (GRCm39) missense possibly damaging 0.90
R1477:Or13a28 UTSW 7 140,218,355 (GRCm39) missense possibly damaging 0.94
R1564:Or13a28 UTSW 7 140,217,967 (GRCm39) missense probably benign 0.21
R1900:Or13a28 UTSW 7 140,218,505 (GRCm39) missense probably damaging 0.99
R2149:Or13a28 UTSW 7 140,217,965 (GRCm39) missense probably damaging 0.99
R2504:Or13a28 UTSW 7 140,218,397 (GRCm39) missense probably benign 0.01
R2887:Or13a28 UTSW 7 140,218,138 (GRCm39) missense probably damaging 1.00
R3787:Or13a28 UTSW 7 140,217,748 (GRCm39) missense probably benign 0.01
R4628:Or13a28 UTSW 7 140,218,297 (GRCm39) missense probably benign 0.04
R4775:Or13a28 UTSW 7 140,217,829 (GRCm39) missense probably damaging 0.98
R5805:Or13a28 UTSW 7 140,218,384 (GRCm39) missense probably benign 0.00
R6019:Or13a28 UTSW 7 140,217,925 (GRCm39) missense probably benign 0.03
R6244:Or13a28 UTSW 7 140,218,346 (GRCm39) missense probably damaging 1.00
R7303:Or13a28 UTSW 7 140,218,267 (GRCm39) missense probably damaging 1.00
R7505:Or13a28 UTSW 7 140,217,965 (GRCm39) missense probably damaging 1.00
R7783:Or13a28 UTSW 7 140,217,637 (GRCm39) missense possibly damaging 0.86
R7936:Or13a28 UTSW 7 140,217,652 (GRCm39) missense probably damaging 1.00
R9060:Or13a28 UTSW 7 140,217,695 (GRCm39) missense
R9114:Or13a28 UTSW 7 140,218,282 (GRCm39) missense probably benign 0.02
Z1088:Or13a28 UTSW 7 140,218,133 (GRCm39) missense probably benign
Posted On 2016-08-02