Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02982:Tas2r135'

406573

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r135

Ensembl Gene

ENSMUSG00000056203

Gene Name

taste receptor, type 2, member 135

Synonyms

mt2r38, Tas2r35

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL02982

Quality Score

Status

Chromosome

Chromosomal Location

42405434-42406526 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42406253 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 242 (E242G)

Ref Sequence

ENSEMBL: ENSMUSP00000070247 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070178]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000070178
AA Change: E242G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000070247
Gene: ENSMUSG00000056203
AA Change: E242G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	22	320	1.3e-63	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	G	T	8: 24,804,431	A384D	probably benign	Het
Adamts19	T	A	18: 59,024,518	C961S	probably damaging	Het
Agbl2	G	A	2: 90,805,815	C565Y	probably damaging	Het
Aox3	G	A	1: 58,127,687	E190K	probably benign	Het
Arf2	T	G	11: 103,981,776	D74E	probably damaging	Het
Bptf	T	G	11: 107,076,674	D960A	probably damaging	Het
Ccdc180	G	T	4: 45,903,840		probably benign	Het
Ces1a	A	G	8: 93,044,975	F65L	probably damaging	Het
Def8	T	C	8: 123,456,539		probably benign	Het
Fat4	T	C	3: 38,890,843	L1295P	probably damaging	Het
Filip1l	A	G	16: 57,572,232	H1061R	probably damaging	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gldc	A	G	19: 30,145,145		probably null	Het
Gm597	T	C	1: 28,778,054	H299R	probably damaging	Het
Golgb1	A	C	16: 36,925,810	D2917A	probably damaging	Het
Gpc5	G	A	14: 115,369,988	C334Y	probably damaging	Het
Gpsm1	T	A	2: 26,324,859	L252Q	probably damaging	Het
Iars	C	T	13: 49,709,709	R546C	probably benign	Het
Kbtbd8	G	T	6: 95,126,566	V399L	probably benign	Het
Kcnd2	A	T	6: 21,217,149	D284V	probably damaging	Het
Kcnj6	T	C	16: 94,832,517	K227R	possibly damaging	Het
Lhx9	A	T	1: 138,838,611	H155Q	probably damaging	Het
Mcm9	A	G	10: 53,625,826	V221A	probably damaging	Het
Myo9a	A	T	9: 59,908,208	K2237*	probably null	Het
Ntf3	A	T	6: 126,102,377	D55E	probably damaging	Het
Olfr1229	G	T	2: 89,283,109	T29K	probably damaging	Het
Olfr61	A	T	7: 140,637,952	I84F	probably benign	Het
Plek	T	A	11: 16,981,826	I342F	probably damaging	Het
Polrmt	A	G	10: 79,738,348	Y853H	probably damaging	Het
Psg29	A	G	7: 17,211,707	T401A	probably damaging	Het
Ptprb	A	G	10: 116,322,628	T822A	probably benign	Het
Ptprq	A	C	10: 107,586,684	F1616V	probably damaging	Het
Rpe65	T	A	3: 159,600,361	V19E	probably damaging	Het
Scamp2	G	A	9: 57,581,549	A178T	probably benign	Het
Spta1	A	G	1: 174,187,288	I445V	probably benign	Het
Ttc22	T	C	4: 106,638,586	V379A	probably damaging	Het
Unc5d	C	T	8: 28,652,853	G857E	probably damaging	Het
Usp28	A	G	9: 49,018,439	I43V	probably benign	Het
Vmn2r68	A	T	7: 85,234,441	M152K	probably benign	Het
Wrn	C	T	8: 33,343,066	G133R	probably damaging	Het
Zfyve26	G	A	12: 79,263,870	T187M	probably damaging	Het
Zic2	A	G	14: 122,478,567	E367G	probably damaging	Het

Other mutations in Tas2r135

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01357:Tas2r135	APN	6	42406144	missense	probably benign	0.00
IGL01395:Tas2r135	APN	6	42405912	nonsense	probably null
IGL02479:Tas2r135	APN	6	42405751	nonsense	probably null
IGL02526:Tas2r135	APN	6	42406280	missense	probably damaging	1.00
IGL02806:Tas2r135	APN	6	42406448	missense	probably benign	0.00
IGL03057:Tas2r135	APN	6	42401127	unclassified	probably benign
R0057:Tas2r135	UTSW	6	42406420	missense	probably benign	0.07
R0104:Tas2r135	UTSW	6	42406324	missense	possibly damaging	0.79
R1412:Tas2r135	UTSW	6	42405834	missense	probably benign	0.00
R4517:Tas2r135	UTSW	6	42406079	missense	probably benign
R4629:Tas2r135	UTSW	6	42406226	missense	probably benign	0.03
R5788:Tas2r135	UTSW	6	42405597	missense	probably damaging	1.00
R6021:Tas2r135	UTSW	6	42406387	missense	probably damaging	1.00
R6586:Tas2r135	UTSW	6	42406018	missense	probably benign	0.18
R7180:Tas2r135	UTSW	6	42405751	nonsense	probably null
R7458:Tas2r135	UTSW	6	42405947	missense	possibly damaging	0.95
R7850:Tas2r135	UTSW	6	42406138	missense	probably benign
R9113:Tas2r135	UTSW	6	42406381	missense	probably benign	0.00
Z1176:Tas2r135	UTSW	6	42406234	missense	probably benign	0.03

Posted On

2016-08-02