Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02982:Psg29'

406600

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg29

Ensembl Gene

ENSMUSG00000023159

Gene Name

pregnancy-specific glycoprotein 29

Synonyms

cea17

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02982

Quality Score

Status

Chromosome

Chromosomal Location

17203477-17215760 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 17211707 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 401 (T401A)

Ref Sequence

ENSEMBL: ENSMUSP00000075320 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075934]

AlphaFold

Q3URN6

Predicted Effect

probably damaging
Transcript: ENSMUST00000075934
AA Change: T401A

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000075320
Gene: ENSMUSG00000023159
AA Change: T401A

Domain	Start	End	E-Value	Type
IG	40	137	7.77e-1	SMART
IG	156	257	8.72e-4	SMART
IG	276	377	2.44e0	SMART
IGc2	393	457	3.06e-8	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	G	T	8: 24,804,431	A384D	probably benign	Het
Adamts19	T	A	18: 59,024,518	C961S	probably damaging	Het
Agbl2	G	A	2: 90,805,815	C565Y	probably damaging	Het
Aox3	G	A	1: 58,127,687	E190K	probably benign	Het
Arf2	T	G	11: 103,981,776	D74E	probably damaging	Het
Bptf	T	G	11: 107,076,674	D960A	probably damaging	Het
Ccdc180	G	T	4: 45,903,840		probably benign	Het
Ces1a	A	G	8: 93,044,975	F65L	probably damaging	Het
Def8	T	C	8: 123,456,539		probably benign	Het
Fat4	T	C	3: 38,890,843	L1295P	probably damaging	Het
Filip1l	A	G	16: 57,572,232	H1061R	probably damaging	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gldc	A	G	19: 30,145,145		probably null	Het
Gm597	T	C	1: 28,778,054	H299R	probably damaging	Het
Golgb1	A	C	16: 36,925,810	D2917A	probably damaging	Het
Gpc5	G	A	14: 115,369,988	C334Y	probably damaging	Het
Gpsm1	T	A	2: 26,324,859	L252Q	probably damaging	Het
Iars	C	T	13: 49,709,709	R546C	probably benign	Het
Kbtbd8	G	T	6: 95,126,566	V399L	probably benign	Het
Kcnd2	A	T	6: 21,217,149	D284V	probably damaging	Het
Kcnj6	T	C	16: 94,832,517	K227R	possibly damaging	Het
Lhx9	A	T	1: 138,838,611	H155Q	probably damaging	Het
Mcm9	A	G	10: 53,625,826	V221A	probably damaging	Het
Myo9a	A	T	9: 59,908,208	K2237*	probably null	Het
Ntf3	A	T	6: 126,102,377	D55E	probably damaging	Het
Olfr1229	G	T	2: 89,283,109	T29K	probably damaging	Het
Olfr61	A	T	7: 140,637,952	I84F	probably benign	Het
Plek	T	A	11: 16,981,826	I342F	probably damaging	Het
Polrmt	A	G	10: 79,738,348	Y853H	probably damaging	Het
Ptprb	A	G	10: 116,322,628	T822A	probably benign	Het
Ptprq	A	C	10: 107,586,684	F1616V	probably damaging	Het
Rpe65	T	A	3: 159,600,361	V19E	probably damaging	Het
Scamp2	G	A	9: 57,581,549	A178T	probably benign	Het
Spta1	A	G	1: 174,187,288	I445V	probably benign	Het
Tas2r135	A	G	6: 42,406,253	E242G	probably benign	Het
Ttc22	T	C	4: 106,638,586	V379A	probably damaging	Het
Unc5d	C	T	8: 28,652,853	G857E	probably damaging	Het
Usp28	A	G	9: 49,018,439	I43V	probably benign	Het
Vmn2r68	A	T	7: 85,234,441	M152K	probably benign	Het
Wrn	C	T	8: 33,343,066	G133R	probably damaging	Het
Zfyve26	G	A	12: 79,263,870	T187M	probably damaging	Het
Zic2	A	G	14: 122,478,567	E367G	probably damaging	Het

Other mutations in Psg29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Psg29	APN	7	17208732	missense	probably benign	0.42
IGL01107:Psg29	APN	7	17204925	missense	probably benign	0.01
IGL01348:Psg29	APN	7	17210673	missense	probably benign	0.09
IGL01353:Psg29	APN	7	17205013	missense	possibly damaging	0.54
IGL02546:Psg29	APN	7	17208782	missense	probably damaging	1.00
IGL02611:Psg29	APN	7	17208791	missense	probably benign	0.15
IGL03072:Psg29	APN	7	17208794	missense	probably benign	0.06
macular	UTSW	7	17210535	missense	probably benign	0.23
papular	UTSW	7	17211912	makesense	probably null
R1744:Psg29	UTSW	7	17210353	missense	probably damaging	1.00
R2272:Psg29	UTSW	7	17210696	missense	probably benign	0.19
R3054:Psg29	UTSW	7	17208802	missense	probably benign	0.29
R3790:Psg29	UTSW	7	17205025	missense	possibly damaging	0.71
R3963:Psg29	UTSW	7	17208585	missense	probably benign	0.01
R4464:Psg29	UTSW	7	17210650	missense	possibly damaging	0.61
R4740:Psg29	UTSW	7	17208533	missense	probably benign	0.00
R4774:Psg29	UTSW	7	17210535	missense	probably benign	0.23
R4902:Psg29	UTSW	7	17211912	makesense	probably null
R4977:Psg29	UTSW	7	17208631	missense	probably damaging	1.00
R5071:Psg29	UTSW	7	17211838	missense	probably damaging	1.00
R5072:Psg29	UTSW	7	17211838	missense	probably damaging	1.00
R5074:Psg29	UTSW	7	17211838	missense	probably damaging	1.00
R5169:Psg29	UTSW	7	17211653	missense	probably damaging	1.00
R5415:Psg29	UTSW	7	17211636	splice site	probably null
R5729:Psg29	UTSW	7	17210534	missense	probably damaging	0.98
R6023:Psg29	UTSW	7	17210512	missense	possibly damaging	0.82
R6127:Psg29	UTSW	7	17211746	missense	probably benign	0.00
R6900:Psg29	UTSW	7	17204932	nonsense	probably null
R7142:Psg29	UTSW	7	17210621	missense	probably damaging	1.00
R7297:Psg29	UTSW	7	17210691	nonsense	probably null
R7448:Psg29	UTSW	7	17211723	missense	possibly damaging	0.90
R7973:Psg29	UTSW	7	17210537	missense	probably benign	0.03
R8027:Psg29	UTSW	7	17208640	missense	possibly damaging	0.69
R8979:Psg29	UTSW	7	17203619	start gained	probably benign
R9744:Psg29	UTSW	7	17210570	missense	probably benign	0.01
X0017:Psg29	UTSW	7	17210661	nonsense	probably null

Posted On

2016-08-02