Incidental Mutation 'IGL02983:Zfp526'
ID 406642
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp526
Ensembl Gene ENSMUSG00000046541
Gene Name zinc finger protein 526
Synonyms D030024H03Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.220) question?
Stock # IGL02983
Quality Score
Status
Chromosome 7
Chromosomal Location 25221425-25227507 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 25224415 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 33 (A33V)
Ref Sequence ENSEMBL: ENSMUSP00000053567 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055604] [ENSMUST00000058702] [ENSMUST00000071739] [ENSMUST00000108411] [ENSMUST00000205271]
AlphaFold Q8BI66
Predicted Effect probably benign
Transcript: ENSMUST00000055604
AA Change: A33V

PolyPhen 2 Score 0.272 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000053567
Gene: ENSMUSG00000046541
AA Change: A33V

DomainStartEndE-ValueType
ZnF_C2H2 56 78 1.41e0 SMART
low complexity region 79 90 N/A INTRINSIC
ZnF_C2H2 108 130 9.46e0 SMART
ZnF_C2H2 140 163 4.65e-1 SMART
low complexity region 171 193 N/A INTRINSIC
ZnF_C2H2 200 222 4.72e-2 SMART
coiled coil region 234 254 N/A INTRINSIC
ZnF_C2H2 280 303 1.26e1 SMART
ZnF_C2H2 312 334 3.29e-1 SMART
ZnF_C2H2 339 361 6.78e-3 SMART
ZnF_C2H2 367 389 4.65e-1 SMART
ZnF_C2H2 395 416 3.56e1 SMART
ZnF_C2H2 447 470 8.47e-4 SMART
ZnF_C2H2 477 499 2.05e-2 SMART
ZnF_C2H2 505 527 2.09e-3 SMART
ZnF_C2H2 533 555 5.99e-4 SMART
ZnF_C2H2 578 600 8.22e-2 SMART
low complexity region 610 624 N/A INTRINSIC
low complexity region 656 670 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000058702
SMART Domains Protein: ENSMUSP00000049763
Gene: ENSMUSG00000054499

DomainStartEndE-ValueType
DED 24 104 6.34e-13 SMART
low complexity region 130 147 N/A INTRINSIC
low complexity region 157 182 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000071739
SMART Domains Protein: ENSMUSP00000071654
Gene: ENSMUSG00000057177

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
low complexity region 25 90 N/A INTRINSIC
S_TKc 119 404 3.11e-84 SMART
low complexity region 481 490 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108411
SMART Domains Protein: ENSMUSP00000104049
Gene: ENSMUSG00000057177

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
low complexity region 25 90 N/A INTRINSIC
S_TKc 119 404 3.11e-84 SMART
low complexity region 477 486 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169914
SMART Domains Protein: ENSMUSP00000126890
Gene: ENSMUSG00000090330

DomainStartEndE-ValueType
low complexity region 77 90 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190693
Predicted Effect probably benign
Transcript: ENSMUST00000205271
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206498
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206750
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206788
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020D05Rik A G 19: 5,503,181 F191L possibly damaging Het
Abca13 A G 11: 9,290,663 N842S probably benign Het
Acvr1b A G 15: 101,203,078 R374G probably damaging Het
Brip1 T C 11: 86,139,124 I565V probably benign Het
Camta2 C T 11: 70,672,022 R959Q probably damaging Het
Cbln2 A G 18: 86,713,379 E104G probably benign Het
Cdc42ep4 T C 11: 113,729,169 K132R probably benign Het
Clcnka T A 4: 141,390,131 I452F probably damaging Het
Clec4a3 T A 6: 122,967,567 probably null Het
Crat A C 2: 30,404,526 probably null Het
Cspp1 A G 1: 10,127,525 K227R probably benign Het
Ddx1 A T 12: 13,223,862 I588N probably damaging Het
Dip2b G T 15: 100,132,022 R98L possibly damaging Het
Dock5 G A 14: 67,764,670 P1617L probably damaging Het
Fa2h C T 8: 111,346,522 probably null Het
Fezf1 T A 6: 23,247,872 N68I probably damaging Het
Gabrb2 A T 11: 42,421,400 L17F probably benign Het
Gm17078 T C 14: 51,611,190 K30R probably benign Het
Gramd4 G A 15: 86,127,018 V249M probably damaging Het
Kcnd2 A C 6: 21,216,555 D86A probably damaging Het
Lrp1 T C 10: 127,550,199 E3486G probably damaging Het
Ltb A G 17: 35,194,670 D50G probably benign Het
Med18 A T 4: 132,459,686 Y167* probably null Het
Nat14 G A 7: 4,924,128 A100T probably damaging Het
Nxph2 T C 2: 23,400,362 V242A probably damaging Het
Olfr338 T A 2: 36,377,637 I287N probably damaging Het
Olfr443-ps1 T C 6: 43,094,648 noncoding transcript Het
Olfr54 T C 11: 51,027,380 V126A probably damaging Het
Olfr818 T A 10: 129,945,189 N291I probably damaging Het
Pramef20 T C 4: 144,373,127 E356G probably benign Het
Rad21l A G 2: 151,655,120 L358S probably damaging Het
Rasgef1c A G 11: 49,957,049 T4A possibly damaging Het
Spata31d1a A G 13: 59,703,694 S207P possibly damaging Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Szt2 T C 4: 118,365,779 probably benign Het
Taf6 T C 5: 138,178,880 T642A probably benign Het
Tmem30a A T 9: 79,771,443 M277K possibly damaging Het
Vmn1r86 T C 7: 13,102,814 D45G probably damaging Het
Xkr5 T C 8: 18,933,832 I565V probably benign Het
Other mutations in Zfp526
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02255:Zfp526 APN 7 25225533 missense possibly damaging 0.89
IGL03123:Zfp526 APN 7 25224624 missense probably benign
R0456:Zfp526 UTSW 7 25226212 missense probably damaging 1.00
R1269:Zfp526 UTSW 7 25224363 missense probably benign
R1542:Zfp526 UTSW 7 25226262 missense probably benign 0.12
R1668:Zfp526 UTSW 7 25225542 missense probably benign 0.15
R1742:Zfp526 UTSW 7 25224514 missense possibly damaging 0.93
R1870:Zfp526 UTSW 7 25225169 missense possibly damaging 0.67
R3791:Zfp526 UTSW 7 25226203 missense probably damaging 0.98
R4755:Zfp526 UTSW 7 25225639 missense probably benign 0.00
R4833:Zfp526 UTSW 7 25225870 missense probably damaging 1.00
R5549:Zfp526 UTSW 7 25225684 missense possibly damaging 0.82
R5853:Zfp526 UTSW 7 25225176 nonsense probably null
R6061:Zfp526 UTSW 7 25226332 missense probably damaging 1.00
R6186:Zfp526 UTSW 7 25226136 missense probably benign
R7270:Zfp526 UTSW 7 25225920 missense probably damaging 1.00
R7882:Zfp526 UTSW 7 25221435 unclassified probably benign
R8084:Zfp526 UTSW 7 25225312 missense probably damaging 0.99
R9016:Zfp526 UTSW 7 25225839 missense probably damaging 1.00
Posted On 2016-08-02