Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02985:Plcl2'

406691

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Plcl2

Ensembl Gene

ENSMUSG00000038910

Gene Name

phospholipase C-like 2

Synonyms

PRIP-2, Plce2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.198) question?

Stock #

IGL02985

Quality Score

Status

Chromosome

Chromosomal Location

50509547-50688493 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 50687814 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Stop codon at position 1104 (E1104*)

Ref Sequence

ENSEMBL: ENSMUSP00000046584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043938]

AlphaFold

Q8K394

Predicted Effect

probably null
Transcript: ENSMUST00000043938
AA Change: E1104*

SMART Domains

Protein: ENSMUSP00000046584
Gene: ENSMUSG00000038910
AA Change: E1104*

Domain	Start	End	E-Value	Type
low complexity region	20	49	N/A	INTRINSIC
PH	143	254	2.88e-5	SMART
Pfam:EF-hand_like	344	426	3.7e-29	PFAM
PLCXc	427	571	2.19e-84	SMART
PLCYc	619	735	4.37e-61	SMART
C2	756	862	3.45e-19	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 36,958,757	L1862S	probably damaging	Het
Actc1	T	C	2: 114,048,160	E318G	probably damaging	Het
Birc6	T	C	17: 74,640,190	V2968A	probably benign	Het
Csgalnact1	A	G	8: 68,461,043	V170A	probably benign	Het
Dph1	A	G	11: 75,183,593	V131A	possibly damaging	Het
Galr1	A	T	18: 82,393,730	M337K	probably benign	Het
Gm14214	G	T	2: 154,769,454	T160N	probably benign	Het
Gpatch8	G	T	11: 102,481,510	H401N	unknown	Het
Higd1a	A	G	9: 121,852,530	F20L	probably benign	Het
Hmcn1	A	T	1: 150,671,917	I2761K	probably damaging	Het
Hspg2	T	A	4: 137,507,803	Y83N	probably damaging	Het
Ilvbl	C	T	10: 78,579,067	P255S	probably benign	Het
Kpna2	T	C	11: 106,989,337	Y495C	probably benign	Het
Krt36	G	T	11: 100,103,179	Q327K	probably benign	Het
Lrrc34	T	C	3: 30,636,295	M153V	probably benign	Het
Maats1	T	A	16: 38,298,272	I722F	probably damaging	Het
Map9	A	T	3: 82,359,902	R30*	probably null	Het
Mcf2l	A	G	8: 12,963,239	Y48C	probably damaging	Het
Mfsd13b	T	A	7: 121,000,172	I397K	probably damaging	Het
Mpp7	C	A	18: 7,461,637		probably null	Het
Mrgprx2	C	T	7: 48,482,497	C191Y	probably damaging	Het
Olfr48	A	T	2: 89,844,340	I211N	possibly damaging	Het
Pabpc4l	A	G	3: 46,446,582	V209A	possibly damaging	Het
Pde7a	T	A	3: 19,310,883	H40L	probably damaging	Het
Phactr3	T	C	2: 178,175,457	V22A	probably benign	Het
Ppp2cb	A	G	8: 33,615,446		probably benign	Het
Prl3c1	A	T	13: 27,199,387	Y12F	probably damaging	Het
Prune2	T	C	19: 17,016,359		probably null	Het
Rfesd	T	C	13: 76,008,212	D25G	probably damaging	Het
Rxfp1	C	A	3: 79,652,226	M429I	possibly damaging	Het
Tmf1	A	G	6: 97,176,809	L101P	probably damaging	Het
Ube2d2b	T	C	5: 107,830,797	S105P	probably damaging	Het
Wdr92	G	A	11: 17,229,845	G282E	probably damaging	Het
Zfp518a	C	T	19: 40,913,667	T680I	possibly damaging	Het

Other mutations in Plcl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00927:Plcl2	APN	17	50606920	missense	probably benign	0.01
IGL01746:Plcl2	APN	17	50607696	missense	probably benign	0.00
IGL02227:Plcl2	APN	17	50606397	missense	probably damaging	0.97
IGL02232:Plcl2	APN	17	50606641	missense	possibly damaging	0.66
IGL02878:Plcl2	APN	17	50607355	missense	probably damaging	1.00
acerbic	UTSW	17	50608113	missense	probably damaging	1.00
Balsamic	UTSW	17	50607661	missense	probably damaging	1.00
Bastante	UTSW	17	50606361	nonsense	probably null
italietta	UTSW	17	50608762	missense	probably damaging	1.00
Oxalic	UTSW	17	50608099	missense	probably damaging	1.00
Parece	UTSW	17	50607846	missense	probably damaging	0.99
picolinic	UTSW	17	50668160	splice site	probably null
ranch	UTSW	17	50509929	missense	probably benign	0.00
verdad	UTSW	17	50608081	missense	probably damaging	1.00
vinagrette	UTSW	17	50606856	nonsense	probably null
BB007:Plcl2	UTSW	17	50606803	missense	probably benign
BB017:Plcl2	UTSW	17	50606803	missense	probably benign
IGL03014:Plcl2	UTSW	17	50611001	missense	possibly damaging	0.65
R0110:Plcl2	UTSW	17	50607982	missense	probably damaging	1.00
R0190:Plcl2	UTSW	17	50607643	missense	probably benign
R0280:Plcl2	UTSW	17	50607034	missense	probably damaging	1.00
R0414:Plcl2	UTSW	17	50607955	missense	possibly damaging	0.90
R0450:Plcl2	UTSW	17	50607982	missense	probably damaging	1.00
R0760:Plcl2	UTSW	17	50608774	missense	possibly damaging	0.82
R1134:Plcl2	UTSW	17	50608110	missense	probably benign
R1168:Plcl2	UTSW	17	50607072	missense	possibly damaging	0.49
R1381:Plcl2	UTSW	17	50607729	missense	probably damaging	0.99
R1748:Plcl2	UTSW	17	50606798	missense	probably benign
R1856:Plcl2	UTSW	17	50607850	missense	probably benign	0.13
R1958:Plcl2	UTSW	17	50608081	missense	probably damaging	1.00
R2016:Plcl2	UTSW	17	50606694	missense	probably damaging	1.00
R2057:Plcl2	UTSW	17	50668111	splice site	probably null
R2077:Plcl2	UTSW	17	50606829	missense	probably benign
R2247:Plcl2	UTSW	17	50606845	missense	probably damaging	0.96
R3083:Plcl2	UTSW	17	50687744	missense	probably benign	0.06
R4153:Plcl2	UTSW	17	50606361	nonsense	probably null
R4574:Plcl2	UTSW	17	50607846	missense	probably damaging	0.99
R4870:Plcl2	UTSW	17	50607226	missense	possibly damaging	0.46
R5030:Plcl2	UTSW	17	50607319	missense	possibly damaging	0.92
R5330:Plcl2	UTSW	17	50509848	missense	probably benign	0.01
R5331:Plcl2	UTSW	17	50509848	missense	probably benign	0.01
R5503:Plcl2	UTSW	17	50509929	missense	probably benign	0.00
R5920:Plcl2	UTSW	17	50608675	missense	probably damaging	0.99
R6238:Plcl2	UTSW	17	50606845	missense	probably damaging	0.96
R6378:Plcl2	UTSW	17	50668160	splice site	probably null
R6603:Plcl2	UTSW	17	50607117	missense	probably benign	0.03
R6633:Plcl2	UTSW	17	50640140	missense	probably benign	0.00
R7113:Plcl2	UTSW	17	50606464	missense	probably damaging	1.00
R7466:Plcl2	UTSW	17	50608468	missense	probably damaging	1.00
R7665:Plcl2	UTSW	17	50607157	missense	probably benign	0.00
R7930:Plcl2	UTSW	17	50606803	missense	probably benign
R8114:Plcl2	UTSW	17	50687787	missense	probably damaging	0.97
R8152:Plcl2	UTSW	17	50607661	missense	probably damaging	1.00
R8208:Plcl2	UTSW	17	50608315	missense	probably damaging	1.00
R8853:Plcl2	UTSW	17	50606856	nonsense	probably null
R8911:Plcl2	UTSW	17	50608113	missense	probably damaging	1.00
R8940:Plcl2	UTSW	17	50608762	missense	probably damaging	1.00
R8979:Plcl2	UTSW	17	50640117	missense	possibly damaging	0.64
R9127:Plcl2	UTSW	17	50611004	missense	probably benign	0.05
R9253:Plcl2	UTSW	17	50608099	missense	probably damaging	1.00
R9453:Plcl2	UTSW	17	50608363	missense	probably damaging	1.00
R9469:Plcl2	UTSW	17	50606925	missense	probably benign	0.05
R9630:Plcl2	UTSW	17	50640119	missense	probably benign
X0026:Plcl2	UTSW	17	50607560	missense	probably benign	0.03
Z1088:Plcl2	UTSW	17	50606992	missense	probably damaging	1.00
Z1176:Plcl2	UTSW	17	50608456	missense	probably damaging	1.00

Posted On

2016-08-02