Incidental Mutation 'IGL02987:Olfr891'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr891
Ensembl Gene ENSMUSG00000045528
Gene Nameolfactory receptor 891
SynonymsGA_x6K02T2PVTD-31862167-31861217, MOR170-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02987
Quality Score
Chromosomal Location38179871-38180821 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 38180623 bp
Amino Acid Change Serine to Threonine at position 67 (S67T)
Ref Sequence ENSEMBL: ENSMUSP00000055451 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062535]
Predicted Effect possibly damaging
Transcript: ENSMUST00000062535
AA Change: S67T

PolyPhen 2 Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000055451
Gene: ENSMUSG00000045528
AA Change: S67T

Pfam:7tm_4 31 306 1e-37 PFAM
Pfam:7tm_1 41 289 9.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182282
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1e1 T C 13: 4,593,592 D222G probably damaging Het
Apbb1ip T A 2: 22,867,637 Y422* probably null Het
Asf1a T C 10: 53,597,271 F28L probably damaging Het
Atp6v1c1 T A 15: 38,690,562 M319K possibly damaging Het
Bsn A G 9: 108,126,304 S301P probably benign Het
Cds1 A G 5: 101,812,525 I281V possibly damaging Het
Col4a4 T C 1: 82,498,925 probably benign Het
Coq2 G A 5: 100,663,688 Q103* probably null Het
Dgkh A G 14: 78,589,872 probably null Het
Dnah9 A G 11: 65,855,272 I4005T probably damaging Het
Dnah9 C A 11: 65,841,273 R4269L probably benign Het
F2rl1 T A 13: 95,514,233 Q47L probably benign Het
Fhod3 T C 18: 25,113,553 V1272A possibly damaging Het
Gdpd4 T C 7: 97,961,551 probably benign Het
Gfral A G 9: 76,197,301 V143A possibly damaging Het
Gltp A C 5: 114,674,182 F88V probably benign Het
Hectd1 T G 12: 51,744,767 K2565T probably damaging Het
Jade2 A G 11: 51,830,481 S207P probably damaging Het
Khdc3 A G 9: 73,102,666 I53V possibly damaging Het
Lce1a1 T C 3: 92,647,102 T22A unknown Het
Lgals9 A T 11: 78,967,477 H196Q possibly damaging Het
Lrrc37a A T 11: 103,500,413 N1395K probably benign Het
Mast1 C T 8: 84,925,719 V268I possibly damaging Het
Myh11 T G 16: 14,232,532 E523A probably damaging Het
Napb T C 2: 148,697,511 probably null Het
Nlrp4e G A 7: 23,301,433 R51H probably damaging Het
Ola1 T C 2: 73,156,898 D130G probably benign Het
Pard3 G A 8: 127,389,491 C687Y probably damaging Het
Rassf9 A G 10: 102,545,248 T164A possibly damaging Het
Sema3a A G 5: 13,565,896 Y429C probably damaging Het
Slc25a54 T C 3: 109,116,337 V416A probably benign Het
Slc30a5 T C 13: 100,803,915 T631A probably damaging Het
Sorl1 A T 9: 42,041,053 C736S probably damaging Het
Tet3 A T 6: 83,368,092 S1788T probably damaging Het
Trim42 A G 9: 97,365,815 V276A probably benign Het
Other mutations in Olfr891
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02821:Olfr891 APN 9 38180668 missense possibly damaging 0.65
R0032:Olfr891 UTSW 9 38180608 missense probably damaging 1.00
R1604:Olfr891 UTSW 9 38180349 missense probably benign 0.12
R1678:Olfr891 UTSW 9 38180637 missense possibly damaging 0.65
R2230:Olfr891 UTSW 9 38180146 missense probably benign 0.00
R4391:Olfr891 UTSW 9 38180349 missense probably damaging 0.99
R4470:Olfr891 UTSW 9 38180370 missense probably damaging 0.96
R4803:Olfr891 UTSW 9 38180250 missense probably damaging 1.00
R4865:Olfr891 UTSW 9 38179900 missense possibly damaging 0.53
R5652:Olfr891 UTSW 9 38180815 missense probably benign 0.01
R5743:Olfr891 UTSW 9 38180718 missense probably benign
R7088:Olfr891 UTSW 9 38180452 missense probably damaging 1.00
R7097:Olfr891 UTSW 9 38180336 nonsense probably null
R7214:Olfr891 UTSW 9 38180022 missense probably damaging 1.00
R7631:Olfr891 UTSW 9 38180706 missense probably damaging 1.00
R8315:Olfr891 UTSW 9 38180209 missense probably benign 0.25
R8327:Olfr891 UTSW 9 38179890 missense possibly damaging 0.72
Posted On2016-08-02