Incidental Mutation 'IGL02989:Olfr1469'
ID406836
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1469
Ensembl Gene ENSMUSG00000063777
Gene Nameolfactory receptor 1469
SynonymsGA_x6K02T2RE5P-3743369-3744289, MOR202-11
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL02989
Quality Score
Status
Chromosome19
Chromosomal Location13407849-13414540 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 13411486 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 306 (Q306K)
Ref Sequence ENSEMBL: ENSMUSP00000150006 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077538] [ENSMUST00000216910]
Predicted Effect probably benign
Transcript: ENSMUST00000077538
AA Change: Q306K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076741
Gene: ENSMUSG00000063777
AA Change: Q306K

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2e-47 PFAM
Pfam:7tm_1 42 290 2.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216910
AA Change: Q306K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a1 T A 19: 20,640,058 probably benign Het
Arhgap15 A G 2: 43,780,736 D44G probably damaging Het
Arhgap35 A T 7: 16,497,655 *1500R probably null Het
Arid1b A G 17: 5,335,047 Y1413C probably damaging Het
Atf6 A G 1: 170,788,683 probably benign Het
BC030867 A G 11: 102,255,299 I134V probably benign Het
Cant1 T C 11: 118,411,212 Y93C probably damaging Het
Cat A G 2: 103,472,973 F153S probably damaging Het
Ccdc187 G A 2: 26,276,431 R712W possibly damaging Het
Clpb T C 7: 101,779,220 S396P probably damaging Het
Cntnap5a A G 1: 116,412,083 probably benign Het
Dap3 G A 3: 88,930,571 probably benign Het
Dnah6 T A 6: 73,069,420 D3195V probably damaging Het
Eprs T G 1: 185,418,366 F1355C probably benign Het
Faim2 A G 15: 99,520,362 probably benign Het
Fam208b A T 13: 3,584,820 H662Q probably benign Het
Fancg A G 4: 43,007,121 probably benign Het
Fbxo42 T A 4: 141,199,534 I375N probably damaging Het
Gabrr3 A T 16: 59,448,008 D328V probably damaging Het
Gm5849 T A 3: 90,777,800 D26V probably damaging Het
Gm6563 T C 19: 23,675,870 L8P possibly damaging Het
Gpld1 A G 13: 24,990,036 N815D possibly damaging Het
Idh2 T A 7: 80,099,108 I142F probably damaging Het
Kcnh7 A C 2: 62,721,925 N907K probably benign Het
Mcm3ap A G 10: 76,471,060 T336A possibly damaging Het
Olfr1211 A T 2: 88,929,704 S204T possibly damaging Het
Olfr556 T C 7: 102,670,444 S175P possibly damaging Het
Pilrb1 C A 5: 137,857,230 R133L possibly damaging Het
Pitpnm3 C A 11: 72,120,186 probably benign Het
Prkdc C T 16: 15,800,016 T3237I possibly damaging Het
Pspc1 A G 14: 56,771,696 probably benign Het
Rasgrp4 G A 7: 29,148,406 E414K probably damaging Het
Rgs12 T A 5: 34,965,119 L82Q probably damaging Het
Sh3gl3 T C 7: 82,273,879 V117A probably benign Het
Shisa5 G A 9: 109,055,994 A112T probably damaging Het
Tedc1 A G 12: 113,163,321 E401G probably benign Het
Tsc22d1 T C 14: 76,418,901 M940T probably benign Het
Vmn1r129 A T 7: 21,360,738 V185E probably damaging Het
Zfp982 C A 4: 147,512,595 D136E possibly damaging Het
Other mutations in Olfr1469
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01064:Olfr1469 APN 19 13411226 missense probably benign 0.01
IGL01520:Olfr1469 APN 19 13410750 missense probably damaging 0.97
IGL01671:Olfr1469 APN 19 13410891 missense probably benign 0.29
IGL02247:Olfr1469 APN 19 13411467 missense probably benign 0.01
IGL02297:Olfr1469 APN 19 13411475 missense probably benign 0.00
IGL02417:Olfr1469 APN 19 13410895 missense possibly damaging 0.52
IGL02442:Olfr1469 APN 19 13410987 missense probably benign 0.00
IGL03269:Olfr1469 APN 19 13411428 missense probably damaging 0.99
IGL02988:Olfr1469 UTSW 19 13411462 missense possibly damaging 0.75
R0707:Olfr1469 UTSW 19 13411420 missense probably benign 0.22
R1055:Olfr1469 UTSW 19 13411390 missense probably benign 0.10
R1102:Olfr1469 UTSW 19 13411090 missense probably damaging 1.00
R1946:Olfr1469 UTSW 19 13410779 missense possibly damaging 0.64
R2111:Olfr1469 UTSW 19 13410943 missense probably damaging 0.99
R4072:Olfr1469 UTSW 19 13410935 missense possibly damaging 0.49
R4073:Olfr1469 UTSW 19 13410935 missense possibly damaging 0.49
R4076:Olfr1469 UTSW 19 13410935 missense possibly damaging 0.49
R4726:Olfr1469 UTSW 19 13411105 missense probably damaging 1.00
R4939:Olfr1469 UTSW 19 13410855 missense probably benign 0.10
R5914:Olfr1469 UTSW 19 13410962 missense probably benign 0.31
R6003:Olfr1469 UTSW 19 13411039 missense probably benign 0.34
R6743:Olfr1469 UTSW 19 13410593 missense probably damaging 1.00
R6825:Olfr1469 UTSW 19 13411150 missense probably benign 0.01
R6826:Olfr1469 UTSW 19 13411088 missense probably benign 0.05
R6970:Olfr1469 UTSW 19 13411428 missense probably damaging 0.99
R7558:Olfr1469 UTSW 19 13410991 missense probably damaging 1.00
R7596:Olfr1469 UTSW 19 13411147 missense probably benign 0.01
R7923:Olfr1469 UTSW 19 13410818 missense probably benign 0.17
R8014:Olfr1469 UTSW 19 13410811 missense not run
R8506:Olfr1469 UTSW 19 13411240 missense possibly damaging 0.49
R8746:Olfr1469 UTSW 19 13410728 missense probably benign 0.44
R8803:Olfr1469 UTSW 19 13410673 missense probably damaging 0.99
Z1177:Olfr1469 UTSW 19 13410719 missense possibly damaging 0.94
Posted On2016-08-02