Incidental Mutation 'IGL02989:Tedc1'
ID 406856
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tedc1
Ensembl Gene ENSMUSG00000037466
Gene Name tubulin epsilon and delta complex 1
Synonyms 4930427A07Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02989
Quality Score
Status
Chromosome 12
Chromosomal Location 113120041-113129668 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 113126941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 401 (E401G)
Ref Sequence ENSEMBL: ENSMUSP00000035351 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049271] [ENSMUST00000196755] [ENSMUST00000200522]
AlphaFold Q3UK37
Predicted Effect probably benign
Transcript: ENSMUST00000049271
AA Change: E401G

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000035351
Gene: ENSMUSG00000037466
AA Change: E401G

DomainStartEndE-ValueType
low complexity region 2 21 N/A INTRINSIC
Pfam:DUF4509 41 221 4.8e-65 PFAM
low complexity region 233 245 N/A INTRINSIC
Pfam:DUF4510 258 418 3.1e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196755
SMART Domains Protein: ENSMUSP00000143431
Gene: ENSMUSG00000037466

DomainStartEndE-ValueType
low complexity region 1 20 N/A INTRINSIC
Pfam:DUF4509 40 138 4.1e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198072
Predicted Effect probably benign
Transcript: ENSMUST00000200522
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a1 T A 19: 20,617,422 (GRCm39) probably benign Het
Arhgap15 A G 2: 43,670,748 (GRCm39) D44G probably damaging Het
Arhgap35 A T 7: 16,231,580 (GRCm39) *1500R probably null Het
Arid1b A G 17: 5,385,322 (GRCm39) Y1413C probably damaging Het
Atf6 A G 1: 170,616,252 (GRCm39) probably benign Het
Cant1 T C 11: 118,302,038 (GRCm39) Y93C probably damaging Het
Cat A G 2: 103,303,318 (GRCm39) F153S probably damaging Het
Ccdc187 G A 2: 26,166,443 (GRCm39) R712W possibly damaging Het
Clpb T C 7: 101,428,427 (GRCm39) S396P probably damaging Het
Cntnap5a A G 1: 116,339,813 (GRCm39) probably benign Het
Dap3 G A 3: 88,837,878 (GRCm39) probably benign Het
Dnah6 T A 6: 73,046,403 (GRCm39) D3195V probably damaging Het
Eprs1 T G 1: 185,150,563 (GRCm39) F1355C probably benign Het
Faim2 A G 15: 99,418,243 (GRCm39) probably benign Het
Fancg A G 4: 43,007,121 (GRCm39) probably benign Het
Fbxo42 T A 4: 140,926,845 (GRCm39) I375N probably damaging Het
Gabrr3 A T 16: 59,268,371 (GRCm39) D328V probably damaging Het
Gm5849 T A 3: 90,685,107 (GRCm39) D26V probably damaging Het
Gm6563 T C 19: 23,653,234 (GRCm39) L8P possibly damaging Het
Gpld1 A G 13: 25,174,019 (GRCm39) N815D possibly damaging Het
Hrob A G 11: 102,146,125 (GRCm39) I134V probably benign Het
Idh2 T A 7: 79,748,856 (GRCm39) I142F probably damaging Het
Kcnh7 A C 2: 62,552,269 (GRCm39) N907K probably benign Het
Mcm3ap A G 10: 76,306,894 (GRCm39) T336A possibly damaging Het
Or4c15 A T 2: 88,760,048 (GRCm39) S204T possibly damaging Het
Or52i2 T C 7: 102,319,651 (GRCm39) S175P possibly damaging Het
Or5b3 C A 19: 13,388,850 (GRCm39) Q306K probably benign Het
Pilrb1 C A 5: 137,855,492 (GRCm39) R133L possibly damaging Het
Pitpnm3 C A 11: 72,011,012 (GRCm39) probably benign Het
Prkdc C T 16: 15,617,880 (GRCm39) T3237I possibly damaging Het
Pspc1 A G 14: 57,009,153 (GRCm39) probably benign Het
Rasgrp4 G A 7: 28,847,831 (GRCm39) E414K probably damaging Het
Rgs12 T A 5: 35,122,463 (GRCm39) L82Q probably damaging Het
Sh3gl3 T C 7: 81,923,087 (GRCm39) V117A probably benign Het
Shisa5 G A 9: 108,885,062 (GRCm39) A112T probably damaging Het
Tasor2 A T 13: 3,634,820 (GRCm39) H662Q probably benign Het
Tsc22d1 T C 14: 76,656,341 (GRCm39) M940T probably benign Het
Vmn1r129 A T 7: 21,094,663 (GRCm39) V185E probably damaging Het
Zfp982 C A 4: 147,597,052 (GRCm39) D136E possibly damaging Het
Other mutations in Tedc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01066:Tedc1 APN 12 113,126,770 (GRCm39) missense probably damaging 0.97
IGL01074:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01075:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01077:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01084:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01103:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01108:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01137:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01142:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01149:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01150:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01151:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL02646:Tedc1 APN 12 113,120,921 (GRCm39) missense possibly damaging 0.68
ANU05:Tedc1 UTSW 12 113,126,808 (GRCm39) nonsense probably null
ANU22:Tedc1 UTSW 12 113,126,808 (GRCm39) nonsense probably null
R1309:Tedc1 UTSW 12 113,125,400 (GRCm39) missense probably benign
R1555:Tedc1 UTSW 12 113,120,117 (GRCm39) unclassified probably benign
R2092:Tedc1 UTSW 12 113,121,340 (GRCm39) missense probably damaging 1.00
R3053:Tedc1 UTSW 12 113,120,087 (GRCm39) unclassified probably benign
R4130:Tedc1 UTSW 12 113,126,828 (GRCm39) missense probably benign 0.01
R5050:Tedc1 UTSW 12 113,120,325 (GRCm39) missense possibly damaging 0.86
R5386:Tedc1 UTSW 12 113,120,302 (GRCm39) missense probably benign 0.03
R6377:Tedc1 UTSW 12 113,124,975 (GRCm39) missense probably damaging 1.00
R6749:Tedc1 UTSW 12 113,121,702 (GRCm39) missense probably damaging 1.00
R6761:Tedc1 UTSW 12 113,125,334 (GRCm39) missense probably damaging 1.00
R8220:Tedc1 UTSW 12 113,120,375 (GRCm39) critical splice donor site probably null
R9240:Tedc1 UTSW 12 113,121,310 (GRCm39) missense probably benign 0.43
Posted On 2016-08-02