Incidental Mutation 'IGL02990:Vmn1r15'
ID 406879
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r15
Ensembl Gene ENSMUSG00000115199
Gene Name vomeronasal 1 receptor 15
Synonyms V1rc6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.117) question?
Stock # IGL02990
Quality Score
Status
Chromosome 6
Chromosomal Location 57257952-57259972 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57258608 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 154 (T154A)
Ref Sequence ENSEMBL: ENSMUSP00000154252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000228297]
AlphaFold Q14C10
Predicted Effect probably benign
Transcript: ENSMUST00000071304
AA Change: T154A

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: T154A

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000228297
AA Change: T154A

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12b G T 11: 69,163,206 V205F probably benign Het
Ampd3 T C 7: 110,807,963 probably benign Het
Arhgef18 G A 8: 3,444,904 V388I probably benign Het
Atp6v1c2 C T 12: 17,294,740 V169I probably damaging Het
Ccdc88b G T 19: 6,847,409 L1328I probably damaging Het
Ces1d C A 8: 93,169,718 probably null Het
Cluh G A 11: 74,667,765 probably null Het
Cpsf7 C A 19: 10,531,795 N23K probably benign Het
Cyp4x1 A T 4: 115,121,749 F191L probably benign Het
Dcn A G 10: 97,509,973 T216A probably benign Het
Dirc2 C A 16: 35,735,491 V200F possibly damaging Het
Drosha C T 15: 12,827,267 probably benign Het
Foxn4 A G 5: 114,272,989 S24P probably damaging Het
Gm11733 A T 11: 117,486,983 probably null Het
Hapln1 A C 13: 89,601,606 Y90S probably benign Het
Igf2r C A 17: 12,710,746 probably benign Het
Jade2 A G 11: 51,831,247 probably benign Het
Kcnh7 A T 2: 62,705,986 L1084H probably benign Het
Kif1a T C 1: 93,039,263 D1155G probably damaging Het
Llgl2 A G 11: 115,854,333 M958V probably benign Het
Lrp2 A G 2: 69,441,396 V4064A possibly damaging Het
Mau2 A G 8: 70,022,255 probably benign Het
Mllt10 T C 2: 18,123,711 probably benign Het
Myo15 A G 11: 60,479,440 T1009A probably benign Het
Myo6 T C 9: 80,276,403 probably null Het
Neil2 G T 14: 63,191,809 H12N possibly damaging Het
Nrde2 T C 12: 100,142,096 E412G probably damaging Het
Olfr114 C T 17: 37,589,668 M228I probably benign Het
Olfr1220 T C 2: 89,097,129 Y266C possibly damaging Het
Patl2 T G 2: 122,124,497 probably null Het
Pkhd1 T C 1: 20,522,963 H1642R possibly damaging Het
Ppp6r1 A G 7: 4,643,023 I199T possibly damaging Het
Prom2 T A 2: 127,528,814 T817S probably benign Het
Slc9b1 A G 3: 135,394,983 probably null Het
Sv2c A T 13: 96,088,378 I141K probably damaging Het
Tas2r139 A T 6: 42,141,104 I57F probably damaging Het
Tep1 A G 14: 50,868,246 S106P possibly damaging Het
Tnni3k T C 3: 154,957,758 D319G probably benign Het
Tom1l2 C T 11: 60,230,236 D461N probably damaging Het
Ugt1a10 T C 1: 88,055,879 L133S probably damaging Het
Usf2 T G 7: 30,955,307 Q161P probably benign Het
Vmn2r95 C A 17: 18,452,036 Y678* probably null Het
Other mutations in Vmn1r15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01645:Vmn1r15 APN 6 57258562 nonsense probably null
IGL02326:Vmn1r15 APN 6 57258270 missense probably benign 0.02
IGL02431:Vmn1r15 APN 6 57258903 missense possibly damaging 0.94
IGL02936:Vmn1r15 APN 6 57258818 nonsense probably null
IGL03177:Vmn1r15 APN 6 57258473 missense probably benign 0.27
IGL03382:Vmn1r15 APN 6 57258570 missense probably benign 0.04
R0531:Vmn1r15 UTSW 6 57258251 missense probably benign 0.10
R1858:Vmn1r15 UTSW 6 57258631 missense probably benign 0.13
R2010:Vmn1r15 UTSW 6 57258284 missense probably benign 0.02
R2055:Vmn1r15 UTSW 6 57258744 missense possibly damaging 0.90
R2291:Vmn1r15 UTSW 6 57258692 missense possibly damaging 0.93
R3697:Vmn1r15 UTSW 6 57258336 missense possibly damaging 0.63
R5161:Vmn1r15 UTSW 6 57258512 missense probably benign 0.00
R5884:Vmn1r15 UTSW 6 57259008 missense probably damaging 0.99
R7287:Vmn1r15 UTSW 6 57258216 missense possibly damaging 0.63
R7376:Vmn1r15 UTSW 6 57258357 missense probably benign 0.11
R7773:Vmn1r15 UTSW 6 57258659 missense probably benign 0.05
R7980:Vmn1r15 UTSW 6 57258414 missense probably damaging 1.00
R8309:Vmn1r15 UTSW 6 57258650 missense probably benign 0.01
R8753:Vmn1r15 UTSW 6 57258910 missense probably benign 0.01
R8765:Vmn1r15 UTSW 6 57258600 missense probably benign 0.01
R8812:Vmn1r15 UTSW 6 57258138 start gained probably benign
Posted On 2016-08-02