Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02990:Vmn1r15'

406879

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r15

Ensembl Gene

ENSMUSG00000115199

Gene Name

vomeronasal 1 receptor 15

Synonyms

V1rc6

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

IGL02990

Quality Score

Status

Chromosome

Chromosomal Location

57257952-57259972 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57258608 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 154 (T154A)

Ref Sequence

ENSEMBL: ENSMUSP00000154252 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000228297]

AlphaFold

Q14C10

Predicted Effect

probably benign
Transcript: ENSMUST00000071304
AA Change: T154A

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: T154A

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	4.5e-56	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228297
AA Change: T154A

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alox12b	G	T	11: 69,163,206	V205F	probably benign	Het
Ampd3	T	C	7: 110,807,963		probably benign	Het
Arhgef18	G	A	8: 3,444,904	V388I	probably benign	Het
Atp6v1c2	C	T	12: 17,294,740	V169I	probably damaging	Het
Ccdc88b	G	T	19: 6,847,409	L1328I	probably damaging	Het
Ces1d	C	A	8: 93,169,718		probably null	Het
Cluh	G	A	11: 74,667,765		probably null	Het
Cpsf7	C	A	19: 10,531,795	N23K	probably benign	Het
Cyp4x1	A	T	4: 115,121,749	F191L	probably benign	Het
Dcn	A	G	10: 97,509,973	T216A	probably benign	Het
Dirc2	C	A	16: 35,735,491	V200F	possibly damaging	Het
Drosha	C	T	15: 12,827,267		probably benign	Het
Foxn4	A	G	5: 114,272,989	S24P	probably damaging	Het
Gm11733	A	T	11: 117,486,983		probably null	Het
Hapln1	A	C	13: 89,601,606	Y90S	probably benign	Het
Igf2r	C	A	17: 12,710,746		probably benign	Het
Jade2	A	G	11: 51,831,247		probably benign	Het
Kcnh7	A	T	2: 62,705,986	L1084H	probably benign	Het
Kif1a	T	C	1: 93,039,263	D1155G	probably damaging	Het
Llgl2	A	G	11: 115,854,333	M958V	probably benign	Het
Lrp2	A	G	2: 69,441,396	V4064A	possibly damaging	Het
Mau2	A	G	8: 70,022,255		probably benign	Het
Mllt10	T	C	2: 18,123,711		probably benign	Het
Myo15	A	G	11: 60,479,440	T1009A	probably benign	Het
Myo6	T	C	9: 80,276,403		probably null	Het
Neil2	G	T	14: 63,191,809	H12N	possibly damaging	Het
Nrde2	T	C	12: 100,142,096	E412G	probably damaging	Het
Olfr114	C	T	17: 37,589,668	M228I	probably benign	Het
Olfr1220	T	C	2: 89,097,129	Y266C	possibly damaging	Het
Patl2	T	G	2: 122,124,497		probably null	Het
Pkhd1	T	C	1: 20,522,963	H1642R	possibly damaging	Het
Ppp6r1	A	G	7: 4,643,023	I199T	possibly damaging	Het
Prom2	T	A	2: 127,528,814	T817S	probably benign	Het
Slc9b1	A	G	3: 135,394,983		probably null	Het
Sv2c	A	T	13: 96,088,378	I141K	probably damaging	Het
Tas2r139	A	T	6: 42,141,104	I57F	probably damaging	Het
Tep1	A	G	14: 50,868,246	S106P	possibly damaging	Het
Tnni3k	T	C	3: 154,957,758	D319G	probably benign	Het
Tom1l2	C	T	11: 60,230,236	D461N	probably damaging	Het
Ugt1a10	T	C	1: 88,055,879	L133S	probably damaging	Het
Usf2	T	G	7: 30,955,307	Q161P	probably benign	Het
Vmn2r95	C	A	17: 18,452,036	Y678*	probably null	Het

Other mutations in Vmn1r15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01645:Vmn1r15	APN	6	57258562	nonsense	probably null
IGL02326:Vmn1r15	APN	6	57258270	missense	probably benign	0.02
IGL02431:Vmn1r15	APN	6	57258903	missense	possibly damaging	0.94
IGL02936:Vmn1r15	APN	6	57258818	nonsense	probably null
IGL03177:Vmn1r15	APN	6	57258473	missense	probably benign	0.27
IGL03382:Vmn1r15	APN	6	57258570	missense	probably benign	0.04
R0531:Vmn1r15	UTSW	6	57258251	missense	probably benign	0.10
R1858:Vmn1r15	UTSW	6	57258631	missense	probably benign	0.13
R2010:Vmn1r15	UTSW	6	57258284	missense	probably benign	0.02
R2055:Vmn1r15	UTSW	6	57258744	missense	possibly damaging	0.90
R2291:Vmn1r15	UTSW	6	57258692	missense	possibly damaging	0.93
R3697:Vmn1r15	UTSW	6	57258336	missense	possibly damaging	0.63
R5161:Vmn1r15	UTSW	6	57258512	missense	probably benign	0.00
R5884:Vmn1r15	UTSW	6	57259008	missense	probably damaging	0.99
R7287:Vmn1r15	UTSW	6	57258216	missense	possibly damaging	0.63
R7376:Vmn1r15	UTSW	6	57258357	missense	probably benign	0.11
R7773:Vmn1r15	UTSW	6	57258659	missense	probably benign	0.05
R7980:Vmn1r15	UTSW	6	57258414	missense	probably damaging	1.00
R8309:Vmn1r15	UTSW	6	57258650	missense	probably benign	0.01
R8753:Vmn1r15	UTSW	6	57258910	missense	probably benign	0.01
R8765:Vmn1r15	UTSW	6	57258600	missense	probably benign	0.01
R8812:Vmn1r15	UTSW	6	57258138	start gained	probably benign

Posted On

2016-08-02