Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02990:Tas2r139'

406882

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r139

Ensembl Gene

ENSMUSG00000047102

Gene Name

taste receptor, type 2, member 139

Synonyms

mt2r34, Tas2r39

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02990

Quality Score

Status

Chromosome

Chromosomal Location

42140936-42141895 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42141104 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 57 (I57F)

Ref Sequence

ENSEMBL: ENSMUSP00000062919 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057686]

Predicted Effect

probably damaging
Transcript: ENSMUST00000057686
AA Change: I57F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000062919
Gene: ENSMUSG00000047102
AA Change: I57F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	13	311	2.5e-64	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alox12b	G	T	11: 69,163,206	V205F	probably benign	Het
Ampd3	T	C	7: 110,807,963		probably benign	Het
Arhgef18	G	A	8: 3,444,904	V388I	probably benign	Het
Atp6v1c2	C	T	12: 17,294,740	V169I	probably damaging	Het
Ccdc88b	G	T	19: 6,847,409	L1328I	probably damaging	Het
Ces1d	C	A	8: 93,169,718		probably null	Het
Cluh	G	A	11: 74,667,765		probably null	Het
Cpsf7	C	A	19: 10,531,795	N23K	probably benign	Het
Cyp4x1	A	T	4: 115,121,749	F191L	probably benign	Het
Dcn	A	G	10: 97,509,973	T216A	probably benign	Het
Dirc2	C	A	16: 35,735,491	V200F	possibly damaging	Het
Drosha	C	T	15: 12,827,267		probably benign	Het
Foxn4	A	G	5: 114,272,989	S24P	probably damaging	Het
Gm11733	A	T	11: 117,486,983		probably null	Het
Hapln1	A	C	13: 89,601,606	Y90S	probably benign	Het
Igf2r	C	A	17: 12,710,746		probably benign	Het
Jade2	A	G	11: 51,831,247		probably benign	Het
Kcnh7	A	T	2: 62,705,986	L1084H	probably benign	Het
Kif1a	T	C	1: 93,039,263	D1155G	probably damaging	Het
Llgl2	A	G	11: 115,854,333	M958V	probably benign	Het
Lrp2	A	G	2: 69,441,396	V4064A	possibly damaging	Het
Mau2	A	G	8: 70,022,255		probably benign	Het
Mllt10	T	C	2: 18,123,711		probably benign	Het
Myo15	A	G	11: 60,479,440	T1009A	probably benign	Het
Myo6	T	C	9: 80,276,403		probably null	Het
Neil2	G	T	14: 63,191,809	H12N	possibly damaging	Het
Nrde2	T	C	12: 100,142,096	E412G	probably damaging	Het
Olfr114	C	T	17: 37,589,668	M228I	probably benign	Het
Olfr1220	T	C	2: 89,097,129	Y266C	possibly damaging	Het
Patl2	T	G	2: 122,124,497		probably null	Het
Pkhd1	T	C	1: 20,522,963	H1642R	possibly damaging	Het
Ppp6r1	A	G	7: 4,643,023	I199T	possibly damaging	Het
Prom2	T	A	2: 127,528,814	T817S	probably benign	Het
Slc9b1	A	G	3: 135,394,983		probably null	Het
Sv2c	A	T	13: 96,088,378	I141K	probably damaging	Het
Tep1	A	G	14: 50,868,246	S106P	possibly damaging	Het
Tnni3k	T	C	3: 154,957,758	D319G	probably benign	Het
Tom1l2	C	T	11: 60,230,236	D461N	probably damaging	Het
Ugt1a10	T	C	1: 88,055,879	L133S	probably damaging	Het
Usf2	T	G	7: 30,955,307	Q161P	probably benign	Het
Vmn1r15	A	G	6: 57,258,608	T154A	probably benign	Het
Vmn2r95	C	A	17: 18,452,036	Y678*	probably null	Het

Other mutations in Tas2r139

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00863:Tas2r139	APN	6	42141121	missense	probably damaging	1.00
IGL01593:Tas2r139	APN	6	42140957	missense	probably benign	0.01
IGL01835:Tas2r139	APN	6	42141432	missense	probably benign	0.21
R0517:Tas2r139	UTSW	6	42141491	missense	probably damaging	0.98
R1106:Tas2r139	UTSW	6	42141545	missense	probably benign	0.36
R1352:Tas2r139	UTSW	6	42140940	missense	probably benign	0.28
R4352:Tas2r139	UTSW	6	42141755	missense	probably damaging	1.00
R4632:Tas2r139	UTSW	6	42141498	missense	probably damaging	1.00
R4785:Tas2r139	UTSW	6	42141284	missense	probably damaging	1.00
R4947:Tas2r139	UTSW	6	42141566	missense	possibly damaging	0.82
R5888:Tas2r139	UTSW	6	42141496	missense	probably damaging	1.00
R6796:Tas2r139	UTSW	6	42141592	missense	probably damaging	1.00

Posted On

2016-08-02