Incidental Mutation 'IGL02990:Dcn'
ID 406888
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcn
Ensembl Gene ENSMUSG00000019929
Gene Name decorin
Synonyms DC, SLRR1B
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02990
Quality Score
Status
Chromosome 10
Chromosomal Location 97315471-97354005 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 97345835 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 216 (T216A)
Ref Sequence ENSEMBL: ENSMUSP00000131431 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105287] [ENSMUST00000163448]
AlphaFold P28654
Predicted Effect probably benign
Transcript: ENSMUST00000105287
AA Change: T216A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000100924
Gene: ENSMUSG00000019929
AA Change: T216A

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
LRRNT 48 80 3.86e-11 SMART
LRR 79 98 2.54e1 SMART
LRR 99 122 1.14e0 SMART
LRR_TYP 123 146 2.91e-2 SMART
LRR 147 167 1.67e2 SMART
LRR 168 193 1.29e2 SMART
LRR 194 217 5.27e1 SMART
LRR 239 262 6.05e0 SMART
LRR 263 286 1.01e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163448
AA Change: T216A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000131431
Gene: ENSMUSG00000019929
AA Change: T216A

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
LRRNT 48 80 3.86e-11 SMART
LRR 79 98 2.54e1 SMART
LRR 99 122 1.14e0 SMART
LRR_TYP 123 146 2.91e-2 SMART
LRR 147 167 1.67e2 SMART
LRR 168 193 1.29e2 SMART
LRR 194 217 5.27e1 SMART
LRR 239 262 6.05e0 SMART
LRR 263 286 1.01e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219539
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mutant mice have fragile skin and exhibit abnormal collagen morphology in skin and tendons, supporting this gene's role in regulating collagen fiber formation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12b G T 11: 69,054,032 (GRCm39) V205F probably benign Het
Ampd3 T C 7: 110,407,170 (GRCm39) probably benign Het
Arhgef18 G A 8: 3,494,904 (GRCm39) V388I probably benign Het
Atp6v1c2 C T 12: 17,344,741 (GRCm39) V169I probably damaging Het
Ccdc88b G T 19: 6,824,777 (GRCm39) L1328I probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Cluh G A 11: 74,558,591 (GRCm39) probably null Het
Cpsf7 C A 19: 10,509,159 (GRCm39) N23K probably benign Het
Cyp4x1 A T 4: 114,978,946 (GRCm39) F191L probably benign Het
Drosha C T 15: 12,827,353 (GRCm39) probably benign Het
Foxn4 A G 5: 114,411,050 (GRCm39) S24P probably damaging Het
Gm11733 A T 11: 117,377,809 (GRCm39) probably null Het
Hapln1 A C 13: 89,749,725 (GRCm39) Y90S probably benign Het
Igf2r C A 17: 12,929,633 (GRCm39) probably benign Het
Jade2 A G 11: 51,722,074 (GRCm39) probably benign Het
Kcnh7 A T 2: 62,536,330 (GRCm39) L1084H probably benign Het
Kif1a T C 1: 92,966,985 (GRCm39) D1155G probably damaging Het
Llgl2 A G 11: 115,745,159 (GRCm39) M958V probably benign Het
Lrp2 A G 2: 69,271,740 (GRCm39) V4064A possibly damaging Het
Mau2 A G 8: 70,474,905 (GRCm39) probably benign Het
Mllt10 T C 2: 18,128,522 (GRCm39) probably benign Het
Myo15a A G 11: 60,370,266 (GRCm39) T1009A probably benign Het
Myo6 T C 9: 80,183,685 (GRCm39) probably null Het
Neil2 G T 14: 63,429,258 (GRCm39) H12N possibly damaging Het
Nrde2 T C 12: 100,108,355 (GRCm39) E412G probably damaging Het
Or14j3 C T 17: 37,900,559 (GRCm39) M228I probably benign Het
Or4c115 T C 2: 88,927,473 (GRCm39) Y266C possibly damaging Het
Patl2 T G 2: 121,954,978 (GRCm39) probably null Het
Pkhd1 T C 1: 20,593,187 (GRCm39) H1642R possibly damaging Het
Ppp6r1 A G 7: 4,646,022 (GRCm39) I199T possibly damaging Het
Prom2 T A 2: 127,370,734 (GRCm39) T817S probably benign Het
Slc49a4 C A 16: 35,555,861 (GRCm39) V200F possibly damaging Het
Slc9b1 A G 3: 135,100,744 (GRCm39) probably null Het
Sv2c A T 13: 96,224,886 (GRCm39) I141K probably damaging Het
Tas2r139 A T 6: 42,118,038 (GRCm39) I57F probably damaging Het
Tep1 A G 14: 51,105,703 (GRCm39) S106P possibly damaging Het
Tnni3k T C 3: 154,663,395 (GRCm39) D319G probably benign Het
Tom1l2 C T 11: 60,121,062 (GRCm39) D461N probably damaging Het
Ugt1a10 T C 1: 87,983,601 (GRCm39) L133S probably damaging Het
Usf2 T G 7: 30,654,732 (GRCm39) Q161P probably benign Het
Vmn1r15 A G 6: 57,235,593 (GRCm39) T154A probably benign Het
Vmn2r95 C A 17: 18,672,298 (GRCm39) Y678* probably null Het
Other mutations in Dcn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01519:Dcn APN 10 97,319,385 (GRCm39) missense probably damaging 1.00
IGL01776:Dcn APN 10 97,330,938 (GRCm39) missense possibly damaging 0.88
IGL02608:Dcn APN 10 97,319,319 (GRCm39) missense probably damaging 0.99
IGL03181:Dcn APN 10 97,319,314 (GRCm39) missense probably damaging 0.98
IGL03268:Dcn APN 10 97,319,240 (GRCm39) missense probably benign
PIT4791001:Dcn UTSW 10 97,343,604 (GRCm39) missense probably benign
R0091:Dcn UTSW 10 97,342,551 (GRCm39) missense probably benign 0.00
R0267:Dcn UTSW 10 97,342,345 (GRCm39) splice site probably benign
R1759:Dcn UTSW 10 97,349,517 (GRCm39) missense probably benign 0.01
R1845:Dcn UTSW 10 97,342,536 (GRCm39) missense probably benign 0.00
R5322:Dcn UTSW 10 97,353,464 (GRCm39) missense probably benign 0.03
R6613:Dcn UTSW 10 97,330,902 (GRCm39) missense probably benign 0.03
R6650:Dcn UTSW 10 97,343,605 (GRCm39) missense probably benign 0.00
R7392:Dcn UTSW 10 97,345,860 (GRCm39) missense probably damaging 0.98
R7596:Dcn UTSW 10 97,345,871 (GRCm39) missense probably damaging 1.00
R7626:Dcn UTSW 10 97,319,340 (GRCm39) missense possibly damaging 0.75
R7874:Dcn UTSW 10 97,346,056 (GRCm39) splice site probably null
R8017:Dcn UTSW 10 97,319,397 (GRCm39) missense probably damaging 1.00
R8049:Dcn UTSW 10 97,349,479 (GRCm39) missense probably damaging 1.00
R8316:Dcn UTSW 10 97,330,939 (GRCm39) missense probably damaging 1.00
R9254:Dcn UTSW 10 97,343,643 (GRCm39) missense probably damaging 1.00
R9273:Dcn UTSW 10 97,343,637 (GRCm39) missense probably damaging 1.00
R9379:Dcn UTSW 10 97,343,643 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02