Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02990:Mllt10'

406910

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mllt10

Ensembl Gene

ENSMUSG00000026743

Gene Name

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10

Synonyms

Af10, D630001B22Rik, B130021D15Rik

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.776) question?

Stock #

IGL02990

Quality Score

Status

Chromosome

Chromosomal Location

18055237-18212388 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 18123711 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000110328 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028076] [ENSMUST00000114669] [ENSMUST00000114671] [ENSMUST00000114680]

AlphaFold

O54826

Predicted Effect

probably benign
Transcript: ENSMUST00000028076

SMART Domains

Protein: ENSMUSP00000028076
Gene: ENSMUSG00000026743

Domain	Start	End	E-Value	Type
PHD	24	72	8.51e-8	SMART
PHD	136	195	2.92e-6	SMART
low complexity region	217	248	N/A	INTRINSIC
low complexity region	258	274	N/A	INTRINSIC
low complexity region	308	326	N/A	INTRINSIC
low complexity region	352	372	N/A	INTRINSIC
low complexity region	490	515	N/A	INTRINSIC
low complexity region	581	594	N/A	INTRINSIC
low complexity region	609	627	N/A	INTRINSIC
low complexity region	674	692	N/A	INTRINSIC
coiled coil region	741	782	N/A	INTRINSIC
low complexity region	836	879	N/A	INTRINSIC
low complexity region	941	952	N/A	INTRINSIC
low complexity region	966	986	N/A	INTRINSIC
low complexity region	997	1018	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114669

SMART Domains

Protein: ENSMUSP00000110317
Gene: ENSMUSG00000026743

Domain	Start	End	E-Value	Type
low complexity region	38	51	N/A	INTRINSIC
low complexity region	66	84	N/A	INTRINSIC
low complexity region	131	149	N/A	INTRINSIC
coiled coil region	198	239	N/A	INTRINSIC
low complexity region	293	336	N/A	INTRINSIC
low complexity region	398	409	N/A	INTRINSIC
low complexity region	423	443	N/A	INTRINSIC
low complexity region	454	475	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114671

SMART Domains

Protein: ENSMUSP00000110319
Gene: ENSMUSG00000026743

Domain	Start	End	E-Value	Type
PHD	58	117	2.92e-6	SMART
low complexity region	139	170	N/A	INTRINSIC
low complexity region	180	196	N/A	INTRINSIC
low complexity region	230	248	N/A	INTRINSIC
low complexity region	274	294	N/A	INTRINSIC
low complexity region	412	437	N/A	INTRINSIC
low complexity region	503	516	N/A	INTRINSIC
low complexity region	531	549	N/A	INTRINSIC
low complexity region	596	614	N/A	INTRINSIC
coiled coil region	663	704	N/A	INTRINSIC
low complexity region	758	801	N/A	INTRINSIC
low complexity region	863	874	N/A	INTRINSIC
low complexity region	888	908	N/A	INTRINSIC
low complexity region	919	940	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114680

SMART Domains

Protein: ENSMUSP00000110328
Gene: ENSMUSG00000026743

Domain	Start	End	E-Value	Type
PHD	24	72	8.51e-8	SMART
PHD	136	195	2.92e-6	SMART
low complexity region	217	248	N/A	INTRINSIC
low complexity region	258	274	N/A	INTRINSIC
low complexity region	308	326	N/A	INTRINSIC
low complexity region	352	372	N/A	INTRINSIC
low complexity region	490	515	N/A	INTRINSIC
low complexity region	581	594	N/A	INTRINSIC
low complexity region	609	627	N/A	INTRINSIC
low complexity region	674	692	N/A	INTRINSIC
coiled coil region	741	782	N/A	INTRINSIC
low complexity region	836	879	N/A	INTRINSIC
low complexity region	941	952	N/A	INTRINSIC
low complexity region	966	986	N/A	INTRINSIC
low complexity region	997	1018	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133649

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148229

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150422

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154041

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alox12b	G	T	11: 69,163,206	V205F	probably benign	Het
Ampd3	T	C	7: 110,807,963		probably benign	Het
Arhgef18	G	A	8: 3,444,904	V388I	probably benign	Het
Atp6v1c2	C	T	12: 17,294,740	V169I	probably damaging	Het
Ccdc88b	G	T	19: 6,847,409	L1328I	probably damaging	Het
Ces1d	C	A	8: 93,169,718		probably null	Het
Cluh	G	A	11: 74,667,765		probably null	Het
Cpsf7	C	A	19: 10,531,795	N23K	probably benign	Het
Cyp4x1	A	T	4: 115,121,749	F191L	probably benign	Het
Dcn	A	G	10: 97,509,973	T216A	probably benign	Het
Dirc2	C	A	16: 35,735,491	V200F	possibly damaging	Het
Drosha	C	T	15: 12,827,267		probably benign	Het
Foxn4	A	G	5: 114,272,989	S24P	probably damaging	Het
Gm11733	A	T	11: 117,486,983		probably null	Het
Hapln1	A	C	13: 89,601,606	Y90S	probably benign	Het
Igf2r	C	A	17: 12,710,746		probably benign	Het
Jade2	A	G	11: 51,831,247		probably benign	Het
Kcnh7	A	T	2: 62,705,986	L1084H	probably benign	Het
Kif1a	T	C	1: 93,039,263	D1155G	probably damaging	Het
Llgl2	A	G	11: 115,854,333	M958V	probably benign	Het
Lrp2	A	G	2: 69,441,396	V4064A	possibly damaging	Het
Mau2	A	G	8: 70,022,255		probably benign	Het
Myo15	A	G	11: 60,479,440	T1009A	probably benign	Het
Myo6	T	C	9: 80,276,403		probably null	Het
Neil2	G	T	14: 63,191,809	H12N	possibly damaging	Het
Nrde2	T	C	12: 100,142,096	E412G	probably damaging	Het
Olfr114	C	T	17: 37,589,668	M228I	probably benign	Het
Olfr1220	T	C	2: 89,097,129	Y266C	possibly damaging	Het
Patl2	T	G	2: 122,124,497		probably null	Het
Pkhd1	T	C	1: 20,522,963	H1642R	possibly damaging	Het
Ppp6r1	A	G	7: 4,643,023	I199T	possibly damaging	Het
Prom2	T	A	2: 127,528,814	T817S	probably benign	Het
Slc9b1	A	G	3: 135,394,983		probably null	Het
Sv2c	A	T	13: 96,088,378	I141K	probably damaging	Het
Tas2r139	A	T	6: 42,141,104	I57F	probably damaging	Het
Tep1	A	G	14: 50,868,246	S106P	possibly damaging	Het
Tnni3k	T	C	3: 154,957,758	D319G	probably benign	Het
Tom1l2	C	T	11: 60,230,236	D461N	probably damaging	Het
Ugt1a10	T	C	1: 88,055,879	L133S	probably damaging	Het
Usf2	T	G	7: 30,955,307	Q161P	probably benign	Het
Vmn1r15	A	G	6: 57,258,608	T154A	probably benign	Het
Vmn2r95	C	A	17: 18,452,036	Y678*	probably null	Het

Other mutations in Mllt10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01646:Mllt10	APN	2	18122317	missense	probably damaging	1.00
IGL02366:Mllt10	APN	2	18065087	missense	probably damaging	0.99
IGL03034:Mllt10	APN	2	18065036	start codon destroyed	probably null	0.55
R0348:Mllt10	UTSW	2	18162613	missense	probably damaging	1.00
R0487:Mllt10	UTSW	2	18207137	missense	probably damaging	0.98
R0492:Mllt10	UTSW	2	18146887	splice site	probably benign
R0518:Mllt10	UTSW	2	18071206	critical splice donor site	probably null
R0720:Mllt10	UTSW	2	18196595	missense	probably benign
R0733:Mllt10	UTSW	2	18203766	intron	probably benign
R1532:Mllt10	UTSW	2	18092835	critical splice donor site	probably null
R1665:Mllt10	UTSW	2	18208790	missense	possibly damaging	0.93
R1768:Mllt10	UTSW	2	18162846	missense	probably damaging	1.00
R2098:Mllt10	UTSW	2	18162653	missense	possibly damaging	0.50
R2114:Mllt10	UTSW	2	18162569	missense	probably benign
R2116:Mllt10	UTSW	2	18162569	missense	probably benign
R2117:Mllt10	UTSW	2	18162569	missense	probably benign
R2179:Mllt10	UTSW	2	18210793	missense	probably damaging	1.00
R2192:Mllt10	UTSW	2	18207060	missense	probably benign	0.11
R2510:Mllt10	UTSW	2	18065124	missense	possibly damaging	0.94
R2511:Mllt10	UTSW	2	18065124	missense	possibly damaging	0.94
R4669:Mllt10	UTSW	2	18203633	missense	probably damaging	1.00
R5004:Mllt10	UTSW	2	18170268	missense	probably damaging	1.00
R5072:Mllt10	UTSW	2	18109874	missense	possibly damaging	0.72
R5187:Mllt10	UTSW	2	18208774	nonsense	probably null
R5561:Mllt10	UTSW	2	18109845	missense	probably damaging	0.98
R6141:Mllt10	UTSW	2	18210793	missense	probably damaging	1.00
R6352:Mllt10	UTSW	2	18123793	missense	probably damaging	1.00
R6844:Mllt10	UTSW	2	18159483	missense	probably benign	0.02
R7060:Mllt10	UTSW	2	18159560	missense	possibly damaging	0.64
R7464:Mllt10	UTSW	2	18170279	missense	probably benign
R7691:Mllt10	UTSW	2	18203611	missense	possibly damaging	0.94
R7691:Mllt10	UTSW	2	18203612	missense	probably null	0.94
R7937:Mllt10	UTSW	2	18206084	missense	probably damaging	1.00
R7956:Mllt10	UTSW	2	18170257	missense	probably benign	0.01
R7976:Mllt10	UTSW	2	18162403	missense	possibly damaging	0.94
R8079:Mllt10	UTSW	2	18123756	missense	probably damaging	0.99
R8084:Mllt10	UTSW	2	18109826	missense	probably damaging	0.99
R8518:Mllt10	UTSW	2	18146859	missense	probably damaging	0.99
R8768:Mllt10	UTSW	2	18162772	missense	probably damaging	1.00
R8826:Mllt10	UTSW	2	18162542	missense	probably benign	0.10
R8850:Mllt10	UTSW	2	18196658	missense	probably benign	0.33
R8932:Mllt10	UTSW	2	18123806	missense	probably benign	0.31
R9009:Mllt10	UTSW	2	18162352	missense	probably damaging	0.96
R9129:Mllt10	UTSW	2	18162593	missense	probably benign	0.41
Z1177:Mllt10	UTSW	2	18171076	critical splice donor site	probably null

Posted On

2016-08-02