Incidental Mutation 'IGL02991:Sgo2a'
ID 406963
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sgo2a
Ensembl Gene ENSMUSG00000026039
Gene Name shugoshin 2A
Synonyms Tripin, 5730576N04Rik, D1Ertd8e, Sgol2, Sgol2a, 1110007N04Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02991 (G1)
Quality Score
Status
Chromosome 1
Chromosomal Location 58035130-58065058 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to T at 58054514 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027202] [ENSMUST00000163061]
AlphaFold Q7TSY8
Predicted Effect probably benign
Transcript: ENSMUST00000027202
SMART Domains Protein: ENSMUSP00000027202
Gene: ENSMUSG00000026039

DomainStartEndE-ValueType
coiled coil region 54 109 N/A INTRINSIC
low complexity region 182 198 N/A INTRINSIC
low complexity region 371 381 N/A INTRINSIC
low complexity region 396 431 N/A INTRINSIC
low complexity region 583 597 N/A INTRINSIC
low complexity region 718 729 N/A INTRINSIC
low complexity region 1068 1078 N/A INTRINSIC
low complexity region 1112 1125 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163061
SMART Domains Protein: ENSMUSP00000124053
Gene: ENSMUSG00000054770

DomainStartEndE-ValueType
BTB 23 123 1.01e-2 SMART
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 95% (73/77)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with abnormalities in meiosis but not in mitosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933416I08Rik TCC TCCC X: 52,692,862 (GRCm39) noncoding transcript Het
Adam23 T C 1: 63,586,978 (GRCm39) probably null Het
Aptx C A 4: 40,686,687 (GRCm39) G199C probably damaging Het
Asap2 T C 12: 21,299,294 (GRCm39) probably benign Het
Atp11b A G 3: 35,881,140 (GRCm39) T566A probably benign Het
Bcas3 C T 11: 85,348,713 (GRCm39) Q202* probably null Het
Cacna1h C A 17: 25,610,286 (GRCm39) R740L possibly damaging Het
Casp8 T A 1: 58,866,438 (GRCm39) N146K probably benign Het
Ccdc63 T C 5: 122,246,275 (GRCm39) M549V probably benign Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cdh20 T C 1: 104,861,972 (GRCm39) S51P probably benign Het
Chd7 T C 4: 8,828,398 (GRCm39) M1113T possibly damaging Het
Cilp TGGG TGG 9: 65,187,412 (GRCm39) probably null Het
Crb1 ACC AC 1: 139,164,822 (GRCm39) probably null Het
Crb1 CG C 1: 139,164,824 (GRCm39) probably null Het
Cxcl11 C T 5: 92,509,169 (GRCm39) R28H probably damaging Het
Defb40 C T 8: 19,025,119 (GRCm39) C29Y probably damaging Het
Fcna G C 2: 25,520,693 (GRCm39) probably benign Het
Fen1 A T 19: 10,178,026 (GRCm39) D139E probably benign Het
Frem3 A G 8: 81,395,511 (GRCm39) E1846G probably damaging Het
Gria2 T A 3: 80,615,116 (GRCm39) K455* probably null Het
Hmcn1 A T 1: 150,614,409 (GRCm39) N1332K possibly damaging Het
Htr5b C T 1: 121,455,756 (GRCm39) V55M probably benign Het
Ighv6-5 A T 12: 114,380,315 (GRCm39) N86K probably benign Het
Il4ra T C 7: 125,174,833 (GRCm39) V347A possibly damaging Het
Itih5 A G 2: 10,256,162 (GRCm39) E876G probably benign Het
Itpkb A T 1: 180,155,279 (GRCm39) probably benign Het
Lbr T C 1: 181,649,117 (GRCm39) Y334C probably damaging Het
Lrfn2 T C 17: 49,377,732 (GRCm39) L271P probably damaging Het
Lss T A 10: 76,379,745 (GRCm39) probably benign Het
Map1a T C 2: 121,132,091 (GRCm39) V731A probably damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mob3b T A 4: 35,083,805 (GRCm39) Q128L probably benign Het
Mog T C 17: 37,334,091 (GRCm39) M1V probably null Het
Mrpl4 A G 9: 20,919,901 (GRCm39) Y284C probably damaging Het
Mtus2 T G 5: 148,250,310 (GRCm39) V310G probably damaging Het
Mup11 ACAGCAGCAGCAGCAGCA ACAGCAGCAGCAGCA 4: 60,618,275 (GRCm39) probably benign Het
Odad4 A G 11: 100,444,698 (GRCm39) S285G probably benign Het
Or10g9 T C 9: 39,911,698 (GRCm39) Y275C probably damaging Het
Or8g55 T A 9: 39,785,362 (GRCm39) S264T probably benign Het
Orc3 T G 4: 34,593,083 (GRCm39) Q328P probably damaging Het
Otulinl T C 15: 27,658,388 (GRCm39) S211G possibly damaging Het
Pcdhb20 G T 18: 37,639,264 (GRCm39) G597C probably damaging Het
Pdxdc1 A G 16: 13,675,260 (GRCm39) I334T probably damaging Het
Ppef2 C T 5: 92,383,759 (GRCm39) W450* probably null Het
Proz G A 8: 13,123,490 (GRCm39) E254K probably benign Het
Psma6 T C 12: 55,454,357 (GRCm39) probably benign Het
Rbm12 C T 2: 155,937,480 (GRCm39) probably benign Het
Ryr2 A G 13: 11,776,192 (GRCm39) V1115A probably damaging Het
Sfxn5 G T 6: 85,266,190 (GRCm39) N102K possibly damaging Het
Slc14a2 A T 18: 78,249,049 (GRCm39) M1K probably null Het
Spag5 T A 11: 78,205,077 (GRCm39) L621M probably damaging Het
Spata31 A G 13: 65,068,533 (GRCm39) Y227C probably benign Het
Speer4c1 A C 5: 15,919,214 (GRCm39) probably benign Het
Supt6 T C 11: 78,116,179 (GRCm39) E728G probably damaging Het
Sympk T A 7: 18,764,502 (GRCm39) L69Q probably damaging Het
Timd4 T A 11: 46,732,974 (GRCm39) probably benign Het
Trh G A 6: 92,220,719 (GRCm39) R48W probably damaging Het
Trip12 C A 1: 84,716,536 (GRCm39) D383Y probably damaging Het
Tspo2 T A 17: 48,757,014 (GRCm39) I23F possibly damaging Het
Tspyl5 A G 15: 33,686,989 (GRCm39) S319P probably damaging Het
Txlnb A G 10: 17,717,201 (GRCm39) K403E probably damaging Het
Vmn2r34 C A 7: 7,675,720 (GRCm39) C556F probably damaging Het
Vps13c C A 9: 67,821,159 (GRCm39) A1223E probably damaging Het
Other mutations in Sgo2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Sgo2a APN 1 58,055,753 (GRCm39) missense probably damaging 1.00
IGL00534:Sgo2a APN 1 58,055,503 (GRCm39) missense probably damaging 1.00
IGL00902:Sgo2a APN 1 58,055,258 (GRCm39) missense probably benign 0.00
IGL01571:Sgo2a APN 1 58,057,133 (GRCm39) missense probably damaging 0.99
IGL02268:Sgo2a APN 1 58,056,881 (GRCm39) missense probably benign 0.10
IGL02756:Sgo2a APN 1 58,055,509 (GRCm39) missense probably damaging 1.00
IGL02887:Sgo2a APN 1 58,055,511 (GRCm39) missense probably damaging 0.99
crazy UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
harpo UTSW 1 58,058,819 (GRCm39) nonsense probably null
mashugana UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
meshugas UTSW 1 58,042,092 (GRCm39) nonsense probably null
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0095:Sgo2a UTSW 1 58,054,714 (GRCm39) missense probably benign 0.11
R0325:Sgo2a UTSW 1 58,055,856 (GRCm39) missense probably benign
R0464:Sgo2a UTSW 1 58,039,253 (GRCm39) missense probably damaging 0.98
R0699:Sgo2a UTSW 1 58,037,308 (GRCm39) nonsense probably null
R1251:Sgo2a UTSW 1 58,039,121 (GRCm39) critical splice acceptor site probably null
R1355:Sgo2a UTSW 1 58,057,124 (GRCm39) missense possibly damaging 0.91
R1457:Sgo2a UTSW 1 58,054,965 (GRCm39) missense probably benign 0.00
R2244:Sgo2a UTSW 1 58,056,213 (GRCm39) missense probably benign 0.00
R3896:Sgo2a UTSW 1 58,052,805 (GRCm39) missense probably damaging 0.99
R4919:Sgo2a UTSW 1 58,037,293 (GRCm39) missense probably damaging 0.99
R5030:Sgo2a UTSW 1 58,056,918 (GRCm39) nonsense probably null
R5123:Sgo2a UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
R5317:Sgo2a UTSW 1 58,054,683 (GRCm39) missense probably benign
R5767:Sgo2a UTSW 1 58,058,819 (GRCm39) nonsense probably null
R5844:Sgo2a UTSW 1 58,055,556 (GRCm39) missense probably damaging 0.99
R6018:Sgo2a UTSW 1 58,056,118 (GRCm39) missense probably benign 0.01
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6450:Sgo2a UTSW 1 58,042,092 (GRCm39) nonsense probably null
R6998:Sgo2a UTSW 1 58,055,799 (GRCm39) missense probably damaging 0.99
R7073:Sgo2a UTSW 1 58,056,944 (GRCm39) missense possibly damaging 0.73
R7508:Sgo2a UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
R7722:Sgo2a UTSW 1 58,055,696 (GRCm39) missense probably benign 0.45
R8094:Sgo2a UTSW 1 58,056,300 (GRCm39) missense possibly damaging 0.77
R8176:Sgo2a UTSW 1 58,056,252 (GRCm39) missense possibly damaging 0.93
R8782:Sgo2a UTSW 1 58,056,616 (GRCm39) start gained probably benign
R8899:Sgo2a UTSW 1 58,058,822 (GRCm39) missense possibly damaging 0.85
R8912:Sgo2a UTSW 1 58,056,560 (GRCm39) missense probably damaging 0.99
R9106:Sgo2a UTSW 1 58,037,283 (GRCm39) missense possibly damaging 0.59
R9256:Sgo2a UTSW 1 58,058,772 (GRCm39) missense possibly damaging 0.77
R9688:Sgo2a UTSW 1 58,056,737 (GRCm39) missense probably damaging 1.00
X0065:Sgo2a UTSW 1 58,055,517 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02