Incidental Mutation 'IGL02992:Prl3d2'
ID 406965
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl3d2
Ensembl Gene ENSMUSG00000062737
Gene Name prolactin family 3, subfamily d, member 1
Synonyms Plib, PL-Ib
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL02992
Quality Score
Status
Chromosome 13
Chromosomal Location 27305681-27311538 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 27311266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 179 (E179D)
Ref Sequence ENSEMBL: ENSMUSP00000079579 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080755] [ENSMUST00000164964]
AlphaFold F6R3P9
Predicted Effect probably benign
Transcript: ENSMUST00000080755
AA Change: E179D

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000079579
Gene: ENSMUSG00000062737
AA Change: E179D

DomainStartEndE-ValueType
Pfam:Hormone_1 17 224 4.5e-72 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164964
AA Change: E180D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000130458
Gene: ENSMUSG00000062737
AA Change: E180D

DomainStartEndE-ValueType
Pfam:Hormone_1 16 223 3e-69 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 121,921,935 (GRCm39) K1164E probably damaging Het
Arhgap42 G A 9: 8,998,249 (GRCm39) probably benign Het
Arhgef12 T C 9: 42,910,373 (GRCm39) D612G probably damaging Het
Cpne3 T C 4: 19,532,486 (GRCm39) D309G probably benign Het
Daw1 T C 1: 83,174,934 (GRCm39) probably benign Het
Daxx T A 17: 34,130,722 (GRCm39) C246S probably damaging Het
Dpp7 T C 2: 25,244,589 (GRCm39) D264G possibly damaging Het
Dync2h1 T A 9: 7,137,074 (GRCm39) H1472L probably benign Het
Fastkd2 T C 1: 63,777,083 (GRCm39) probably benign Het
Fcrl2 T G 3: 87,166,773 (GRCm39) R73S probably damaging Het
Gatb A G 3: 85,526,223 (GRCm39) D367G probably damaging Het
Gm20547 T A 17: 35,076,095 (GRCm39) E654V probably damaging Het
Gm839 T A 6: 89,189,509 (GRCm39) noncoding transcript Het
Gtf2ird2 A T 5: 134,246,456 (GRCm39) M905L possibly damaging Het
Hoxb2 A T 11: 96,243,910 (GRCm39) I174F probably damaging Het
Hrh3 A G 2: 179,742,608 (GRCm39) V308A probably benign Het
Ints9 A G 14: 65,217,613 (GRCm39) K47E probably benign Het
Irak3 A T 10: 120,018,566 (GRCm39) Y61N probably damaging Het
Itpr1 A G 6: 108,358,276 (GRCm39) E614G probably damaging Het
Lgals3 A T 14: 47,622,982 (GRCm39) I214L probably benign Het
Msh4 G T 3: 153,577,962 (GRCm39) T444K possibly damaging Het
Myh7b C A 2: 155,463,330 (GRCm39) Q521K probably damaging Het
Naip5 T A 13: 100,359,536 (GRCm39) I567F probably damaging Het
Nf1 A G 11: 79,325,759 (GRCm39) probably benign Het
Nlrc3 C T 16: 3,771,887 (GRCm39) probably benign Het
Nlrc5 A C 8: 95,233,201 (GRCm39) E1353A possibly damaging Het
Nr1h3 T A 2: 91,020,911 (GRCm39) I260F probably damaging Het
Pcnx1 G A 12: 82,010,894 (GRCm39) R1211Q probably damaging Het
Pde10a A G 17: 9,168,293 (GRCm39) K605E probably damaging Het
Pdzd2 T C 15: 12,382,708 (GRCm39) E1215G possibly damaging Het
Pex12 A G 11: 83,188,753 (GRCm39) S81P probably damaging Het
Pik3c2b C A 1: 132,994,718 (GRCm39) Y227* probably null Het
Ppef2 C T 5: 92,383,759 (GRCm39) W450* probably null Het
Prkg2 T G 5: 99,172,365 (GRCm39) S117R probably benign Het
Relch T A 1: 105,647,189 (GRCm39) L684M possibly damaging Het
Rxfp2 T C 5: 149,975,021 (GRCm39) V210A probably benign Het
Scn10a T C 9: 119,438,626 (GRCm39) T1748A possibly damaging Het
Septin10 T C 10: 59,028,000 (GRCm39) N107S possibly damaging Het
Smu1 T A 4: 40,739,550 (GRCm39) N420I probably damaging Het
Sos1 A G 17: 80,726,445 (GRCm39) F835L probably benign Het
Spg11 T C 2: 121,888,879 (GRCm39) D2164G probably damaging Het
Svbp A G 4: 119,053,127 (GRCm39) E8G probably damaging Het
Tgm3 T A 2: 129,883,899 (GRCm39) M519K probably damaging Het
Tspan12 A G 6: 21,799,876 (GRCm39) probably null Het
Vps52 T C 17: 34,177,324 (GRCm39) V122A probably damaging Het
Wipf1 T C 2: 73,264,427 (GRCm39) Y458C probably damaging Het
Zfp369 T A 13: 65,442,265 (GRCm39) D286E possibly damaging Het
Other mutations in Prl3d2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Prl3d2 APN 13 27,306,332 (GRCm39) missense probably damaging 1.00
IGL01362:Prl3d2 APN 13 27,306,438 (GRCm39) nonsense probably null
IGL02647:Prl3d2 APN 13 27,309,999 (GRCm39) missense probably benign 0.06
IGL02751:Prl3d2 APN 13 27,310,014 (GRCm39) critical splice donor site probably null
R1116:Prl3d2 UTSW 13 27,309,985 (GRCm39) missense probably damaging 1.00
R1500:Prl3d2 UTSW 13 27,305,689 (GRCm39) unclassified probably benign
R4713:Prl3d2 UTSW 13 27,306,379 (GRCm39) missense probably benign
R5193:Prl3d2 UTSW 13 27,306,312 (GRCm39) missense possibly damaging 0.87
R6386:Prl3d2 UTSW 13 27,311,286 (GRCm39) missense probably damaging 0.97
R7830:Prl3d2 UTSW 13 27,310,000 (GRCm39) missense probably benign 0.00
R7999:Prl3d2 UTSW 13 27,307,949 (GRCm39) missense probably benign 0.00
R8446:Prl3d2 UTSW 13 27,307,976 (GRCm39) missense probably benign 0.25
R8837:Prl3d2 UTSW 13 27,307,926 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02