Incidental Mutation 'IGL02993:Slfn9'
ID 407017
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slfn9
Ensembl Gene ENSMUSG00000069793
Gene Name schlafen 9
Synonyms 9830137M10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL02993
Quality Score
Status
Chromosome 11
Chromosomal Location 82869216-82882656 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 82872022 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 905 (S905G)
Ref Sequence ENSEMBL: ENSMUSP00000090515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038211] [ENSMUST00000092840] [ENSMUST00000138797]
AlphaFold B1ARD6
Predicted Effect probably benign
Transcript: ENSMUST00000038211
AA Change: S905G

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000044435
Gene: ENSMUSG00000069793
AA Change: S905G

DomainStartEndE-ValueType
low complexity region 28 44 N/A INTRINSIC
Pfam:AlbA_2 205 343 2.3e-17 PFAM
Pfam:DUF2075 592 766 9.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000092840
AA Change: S905G

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000090515
Gene: ENSMUSG00000069793
AA Change: S905G

DomainStartEndE-ValueType
low complexity region 28 44 N/A INTRINSIC
Pfam:AAA_4 205 344 1.6e-18 PFAM
Pfam:DUF2075 592 766 1.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138797
SMART Domains Protein: ENSMUSP00000115273
Gene: ENSMUSG00000069793

DomainStartEndE-ValueType
low complexity region 28 44 N/A INTRINSIC
Pfam:AAA_4 205 344 3.8e-19 PFAM
Pfam:DUF2075 592 642 1.9e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183379
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd3 A C 3: 121,567,659 (GRCm39) I434S probably benign Het
Actr2 C T 11: 20,022,514 (GRCm39) R319Q probably damaging Het
Atp13a5 G T 16: 29,112,322 (GRCm39) Y606* probably null Het
Baiap3 C T 17: 25,469,056 (GRCm39) probably null Het
Cers2 A G 3: 95,227,396 (GRCm39) Y8C probably benign Het
Ces1g T A 8: 94,043,707 (GRCm39) M411L probably benign Het
Chd6 A G 2: 160,894,304 (GRCm39) probably benign Het
Cyp2d40 C A 15: 82,645,722 (GRCm39) K94N probably benign Het
Ddx51 T C 5: 110,803,487 (GRCm39) V323A possibly damaging Het
Dock1 G A 7: 134,346,027 (GRCm39) V190I probably benign Het
Evc2 A G 5: 37,576,501 (GRCm39) T1042A probably benign Het
Fat4 T A 3: 39,011,304 (GRCm39) S2135T probably damaging Het
Gpat2 T C 2: 127,269,486 (GRCm39) F46S probably damaging Het
Klhl38 T A 15: 58,185,851 (GRCm39) K293* probably null Het
Map4k4 T C 1: 40,053,348 (GRCm39) I916T probably damaging Het
Nrap T A 19: 56,333,965 (GRCm39) K964M probably damaging Het
Osbpl5 T C 7: 143,253,071 (GRCm39) probably null Het
Perm1 A G 4: 156,302,236 (GRCm39) Q260R probably benign Het
Ralgapb T A 2: 158,279,314 (GRCm39) N133K possibly damaging Het
Scart2 A G 7: 139,876,486 (GRCm39) T537A probably benign Het
Spata31g1 T C 4: 42,971,719 (GRCm39) Y351H probably damaging Het
Ssh2 C T 11: 77,344,370 (GRCm39) T785I probably damaging Het
Stk16 C A 1: 75,189,648 (GRCm39) Q69K probably damaging Het
Stk36 T C 1: 74,661,446 (GRCm39) L491P probably benign Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Tcp11 T C 17: 28,289,490 (GRCm39) N194D probably damaging Het
Trio C A 15: 27,830,325 (GRCm39) probably benign Het
Ugt2b1 A G 5: 87,069,850 (GRCm39) V297A possibly damaging Het
Ugt2b5 T G 5: 87,285,091 (GRCm39) H282P probably damaging Het
Usp53 A G 3: 122,727,492 (GRCm39) M1030T probably damaging Het
Vmn1r234 T A 17: 21,449,965 (GRCm39) I293N probably damaging Het
Vmn2r57 T A 7: 41,077,498 (GRCm39) T223S probably benign Het
Wdr20 G T 12: 110,760,742 (GRCm39) E543* probably null Het
Zbtb25 T A 12: 76,396,191 (GRCm39) N344Y probably damaging Het
Zcchc2 T C 1: 105,957,898 (GRCm39) F790L probably damaging Het
Other mutations in Slfn9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00900:Slfn9 APN 11 82,872,197 (GRCm39) nonsense probably null
IGL01340:Slfn9 APN 11 82,872,577 (GRCm39) missense probably benign 0.29
IGL01543:Slfn9 APN 11 82,878,775 (GRCm39) missense probably benign
IGL01735:Slfn9 APN 11 82,873,158 (GRCm39) missense probably damaging 1.00
IGL01778:Slfn9 APN 11 82,878,200 (GRCm39) missense probably damaging 0.98
IGL01863:Slfn9 APN 11 82,872,151 (GRCm39) missense probably benign 0.27
IGL01997:Slfn9 APN 11 82,878,503 (GRCm39) missense possibly damaging 0.80
IGL02380:Slfn9 APN 11 82,872,046 (GRCm39) missense probably benign 0.23
R1463:Slfn9 UTSW 11 82,872,524 (GRCm39) missense possibly damaging 0.78
R1687:Slfn9 UTSW 11 82,872,983 (GRCm39) missense probably damaging 0.99
R1786:Slfn9 UTSW 11 82,872,133 (GRCm39) missense probably damaging 0.99
R1796:Slfn9 UTSW 11 82,872,781 (GRCm39) missense probably benign 0.00
R1870:Slfn9 UTSW 11 82,872,402 (GRCm39) missense probably benign
R1871:Slfn9 UTSW 11 82,872,402 (GRCm39) missense probably benign
R2004:Slfn9 UTSW 11 82,879,027 (GRCm39) missense probably benign 0.25
R2024:Slfn9 UTSW 11 82,872,507 (GRCm39) missense probably damaging 1.00
R2106:Slfn9 UTSW 11 82,878,506 (GRCm39) missense possibly damaging 0.89
R2140:Slfn9 UTSW 11 82,875,481 (GRCm39) missense possibly damaging 0.76
R3004:Slfn9 UTSW 11 82,872,590 (GRCm39) missense possibly damaging 0.94
R4293:Slfn9 UTSW 11 82,873,334 (GRCm39) missense probably benign 0.01
R4927:Slfn9 UTSW 11 82,872,216 (GRCm39) missense possibly damaging 0.47
R4950:Slfn9 UTSW 11 82,872,730 (GRCm39) missense probably benign
R5471:Slfn9 UTSW 11 82,873,613 (GRCm39) missense possibly damaging 0.85
R5543:Slfn9 UTSW 11 82,873,207 (GRCm39) missense probably damaging 1.00
R5576:Slfn9 UTSW 11 82,872,258 (GRCm39) missense probably benign
R5996:Slfn9 UTSW 11 82,878,310 (GRCm39) missense possibly damaging 0.67
R7272:Slfn9 UTSW 11 82,872,387 (GRCm39) missense probably benign 0.36
R7421:Slfn9 UTSW 11 82,878,562 (GRCm39) missense probably damaging 0.96
R7421:Slfn9 UTSW 11 82,872,197 (GRCm39) nonsense probably null
R7498:Slfn9 UTSW 11 82,873,013 (GRCm39) missense probably damaging 0.98
R7788:Slfn9 UTSW 11 82,873,467 (GRCm39) missense possibly damaging 0.85
R8286:Slfn9 UTSW 11 82,872,095 (GRCm39) missense probably damaging 0.99
R8304:Slfn9 UTSW 11 82,873,605 (GRCm39) missense probably benign 0.14
R8388:Slfn9 UTSW 11 82,878,112 (GRCm39) missense probably benign
R8678:Slfn9 UTSW 11 82,872,370 (GRCm39) missense probably benign 0.33
R8730:Slfn9 UTSW 11 82,878,194 (GRCm39) missense possibly damaging 0.80
R8914:Slfn9 UTSW 11 82,872,132 (GRCm39) missense probably damaging 0.99
R9050:Slfn9 UTSW 11 82,879,120 (GRCm39) missense probably benign 0.00
R9424:Slfn9 UTSW 11 82,878,211 (GRCm39) missense possibly damaging 0.75
R9576:Slfn9 UTSW 11 82,878,211 (GRCm39) missense possibly damaging 0.75
Z1176:Slfn9 UTSW 11 82,873,261 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02