Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02993:Vmn2r57'

407020

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r57

Ensembl Gene

ENSMUSG00000066537

Gene Name

vomeronasal 2, receptor 57

Synonyms

EG269902

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.126) question?

Stock #

IGL02993

Quality Score

Status

Chromosome

Chromosomal Location

41399732-41448641 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 41428074 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 223 (T223S)

Ref Sequence

ENSEMBL: ENSMUSP00000125817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]

Predicted Effect

probably benign
Transcript: ENSMUST00000094532

Predicted Effect

probably benign
Transcript: ENSMUST00000165029
AA Change: T223S

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: T223S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.4e-44	PFAM
Pfam:NCD3G	514	567	2.7e-23	PFAM
Pfam:7tm_3	600	835	1.8e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	T	C	4: 42,971,719	Y351H	probably damaging	Het
5830411N06Rik	A	G	7: 140,296,573	T537A	probably benign	Het
Abcd3	A	C	3: 121,774,010	I434S	probably benign	Het
Actr2	C	T	11: 20,072,514	R319Q	probably damaging	Het
Atp13a5	G	T	16: 29,293,504	Y606*	probably null	Het
Baiap3	C	T	17: 25,250,082		probably null	Het
Cers2	A	G	3: 95,320,085	Y8C	probably benign	Het
Ces1g	T	A	8: 93,317,079	M411L	probably benign	Het
Chd6	A	G	2: 161,052,384		probably benign	Het
Cyp2d40	C	A	15: 82,761,521	K94N	probably benign	Het
Ddx51	T	C	5: 110,655,621	V323A	possibly damaging	Het
Dock1	G	A	7: 134,744,298	V190I	probably benign	Het
Evc2	A	G	5: 37,419,157	T1042A	probably benign	Het
Fat4	T	A	3: 38,957,155	S2135T	probably damaging	Het
Gpat2	T	C	2: 127,427,566	F46S	probably damaging	Het
Klhl38	T	A	15: 58,322,455	K293*	probably null	Het
Map4k4	T	C	1: 40,014,188	I916T	probably damaging	Het
Nrap	T	A	19: 56,345,533	K964M	probably damaging	Het
Osbpl5	T	C	7: 143,699,334		probably null	Het
Perm1	A	G	4: 156,217,779	Q260R	probably benign	Het
Ralgapb	T	A	2: 158,437,394	N133K	possibly damaging	Het
Slfn9	T	C	11: 82,981,196	S905G	probably benign	Het
Ssh2	C	T	11: 77,453,544	T785I	probably damaging	Het
Stk16	C	A	1: 75,213,004	Q69K	probably damaging	Het
Stk36	T	C	1: 74,622,287	L491P	probably benign	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Tcp11	T	C	17: 28,070,516	N194D	probably damaging	Het
Trio	C	A	15: 27,830,239		probably benign	Het
Ugt2b1	A	G	5: 86,921,991	V297A	possibly damaging	Het
Ugt2b5	T	G	5: 87,137,232	H282P	probably damaging	Het
Usp53	A	G	3: 122,933,843	M1030T	probably damaging	Het
Vmn1r234	T	A	17: 21,229,703	I293N	probably damaging	Het
Wdr20	G	T	12: 110,794,308	E543*	probably null	Het
Zbtb25	T	A	12: 76,349,417	N344Y	probably damaging	Het
Zcchc2	T	C	1: 106,030,168	F790L	probably damaging	Het

Other mutations in Vmn2r57

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Vmn2r57	APN	7	41428785	missense	probably benign
IGL01108:Vmn2r57	APN	7	41427584	missense	probably benign	0.01
IGL01112:Vmn2r57	APN	7	41425043	missense	probably damaging	1.00
IGL01516:Vmn2r57	APN	7	41399946	missense	probably damaging	1.00
IGL01880:Vmn2r57	APN	7	41400195	missense	possibly damaging	0.73
IGL02117:Vmn2r57	APN	7	41400450	missense	probably benign	0.00
IGL02500:Vmn2r57	APN	7	41428226	missense	probably benign
IGL02801:Vmn2r57	APN	7	41448632	missense	probably benign	0.13
IGL02996:Vmn2r57	APN	7	41399741	missense	probably benign	0.02
R0008:Vmn2r57	UTSW	7	41400652	missense	probably damaging	1.00
R0032:Vmn2r57	UTSW	7	41399733	splice site	probably null
R0305:Vmn2r57	UTSW	7	41427543	missense	probably benign	0.00
R0469:Vmn2r57	UTSW	7	41427792	missense	possibly damaging	0.58
R0510:Vmn2r57	UTSW	7	41427792	missense	possibly damaging	0.58
R0847:Vmn2r57	UTSW	7	41428801	missense	probably benign	0.00
R1025:Vmn2r57	UTSW	7	41427804	missense	probably benign	0.24
R1081:Vmn2r57	UTSW	7	41428211	missense	possibly damaging	0.47
R1479:Vmn2r57	UTSW	7	41427830	missense	possibly damaging	0.45
R1579:Vmn2r57	UTSW	7	41400124	missense	probably benign	0.38
R1764:Vmn2r57	UTSW	7	41400643	missense	probably damaging	1.00
R1848:Vmn2r57	UTSW	7	41428107	missense	probably damaging	1.00
R2006:Vmn2r57	UTSW	7	41448577	missense	probably benign	0.00
R2197:Vmn2r57	UTSW	7	41428825	critical splice acceptor site	probably null
R2242:Vmn2r57	UTSW	7	41428074	missense	probably benign	0.00
R2394:Vmn2r57	UTSW	7	41400195	missense	possibly damaging	0.73
R3937:Vmn2r57	UTSW	7	41428130	missense	probably damaging	0.97
R4193:Vmn2r57	UTSW	7	41428239	missense	probably benign
R4423:Vmn2r57	UTSW	7	41426640	missense	probably damaging	1.00
R4865:Vmn2r57	UTSW	7	41400468	missense	probably damaging	1.00
R4947:Vmn2r57	UTSW	7	41400495	missense	probably damaging	1.00
R5042:Vmn2r57	UTSW	7	41428662	missense	probably benign	0.06
R5084:Vmn2r57	UTSW	7	41426550	critical splice donor site	probably null
R5177:Vmn2r57	UTSW	7	41400240	missense	probably benign	0.31
R5192:Vmn2r57	UTSW	7	41427939	missense	probably damaging	0.96
R5289:Vmn2r57	UTSW	7	41399974	missense	probably damaging	0.99
R5745:Vmn2r57	UTSW	7	41448471	missense	possibly damaging	0.51
R6051:Vmn2r57	UTSW	7	41448472	missense	probably benign	0.00
R6155:Vmn2r57	UTSW	7	41428690	missense	probably benign	0.14
R6248:Vmn2r57	UTSW	7	41399860	missense	probably benign
R6381:Vmn2r57	UTSW	7	41428818	missense	probably benign	0.08
R7019:Vmn2r57	UTSW	7	41428665	missense	probably damaging	1.00
R7126:Vmn2r57	UTSW	7	41399794	missense	possibly damaging	0.93
R7146:Vmn2r57	UTSW	7	41448471	missense	possibly damaging	0.51
R7215:Vmn2r57	UTSW	7	41400286	missense	probably benign	0.00
R7432:Vmn2r57	UTSW	7	41426724	missense	probably benign	0.01
R7633:Vmn2r57	UTSW	7	41425089	missense	possibly damaging	0.76
R7811:Vmn2r57	UTSW	7	41425015	nonsense	probably null
R8025:Vmn2r57	UTSW	7	41426759	missense	probably benign	0.00
R8332:Vmn2r57	UTSW	7	41400253	missense	probably benign	0.01
R8345:Vmn2r57	UTSW	7	41427544	missense	possibly damaging	0.81
R8360:Vmn2r57	UTSW	7	41400216	missense	probably damaging	1.00
R8738:Vmn2r57	UTSW	7	41427596	missense	probably benign	0.00
R8758:Vmn2r57	UTSW	7	41428739	missense	probably damaging	1.00
X0026:Vmn2r57	UTSW	7	41428125	missense	probably benign	0.03
X0026:Vmn2r57	UTSW	7	41428561	missense	possibly damaging	0.91
X0065:Vmn2r57	UTSW	7	41427971	missense	probably benign	0.09
Z1176:Vmn2r57	UTSW	7	41400498	missense	probably damaging	0.99

Posted On

2016-08-02