Incidental Mutation 'IGL02993:Zbtb25'
ID 407036
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zbtb25
Ensembl Gene ENSMUSG00000056459
Gene Name zinc finger and BTB domain containing 25
Synonyms Kup, Zfp-50, Zfp50, 2810462M08Rik, 2900064P18Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL02993
Quality Score
Status
Chromosome 12
Chromosomal Location 76347782-76369602 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 76349417 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 344 (N344Y)
Ref Sequence ENSEMBL: ENSMUSP00000134748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167011] [ENSMUST00000176102] [ENSMUST00000176187] [ENSMUST00000176278] [ENSMUST00000176509] [ENSMUST00000176967]
AlphaFold G3UW50
Predicted Effect probably damaging
Transcript: ENSMUST00000167011
AA Change: N344Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128471
Gene: ENSMUSG00000056459
AA Change: N344Y

DomainStartEndE-ValueType
BTB 24 119 4.59e-15 SMART
low complexity region 213 224 N/A INTRINSIC
ZnF_C2H2 239 261 4.4e-2 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000176102
AA Change: N344Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000135853
Gene: ENSMUSG00000056459
AA Change: N344Y

DomainStartEndE-ValueType
BTB 24 119 4.59e-15 SMART
low complexity region 213 224 N/A INTRINSIC
ZnF_C2H2 239 261 4.4e-2 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176187
SMART Domains Protein: ENSMUSP00000135458
Gene: ENSMUSG00000056459

DomainStartEndE-ValueType
BTB 24 119 4.59e-15 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000176278
AA Change: N344Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134748
Gene: ENSMUSG00000056459
AA Change: N344Y

DomainStartEndE-ValueType
BTB 24 119 4.59e-15 SMART
low complexity region 213 224 N/A INTRINSIC
ZnF_C2H2 239 261 4.4e-2 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176509
SMART Domains Protein: ENSMUSP00000135817
Gene: ENSMUSG00000056459

DomainStartEndE-ValueType
Pfam:BTB 14 65 1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176967
SMART Domains Protein: ENSMUSP00000135434
Gene: ENSMUSG00000056459

DomainStartEndE-ValueType
BTB 24 99 1.06e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220077
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700022I11Rik T C 4: 42,971,719 Y351H probably damaging Het
5830411N06Rik A G 7: 140,296,573 T537A probably benign Het
Abcd3 A C 3: 121,774,010 I434S probably benign Het
Actr2 C T 11: 20,072,514 R319Q probably damaging Het
Atp13a5 G T 16: 29,293,504 Y606* probably null Het
Baiap3 C T 17: 25,250,082 probably null Het
Cers2 A G 3: 95,320,085 Y8C probably benign Het
Ces1g T A 8: 93,317,079 M411L probably benign Het
Chd6 A G 2: 161,052,384 probably benign Het
Cyp2d40 C A 15: 82,761,521 K94N probably benign Het
Ddx51 T C 5: 110,655,621 V323A possibly damaging Het
Dock1 G A 7: 134,744,298 V190I probably benign Het
Evc2 A G 5: 37,419,157 T1042A probably benign Het
Fat4 T A 3: 38,957,155 S2135T probably damaging Het
Gpat2 T C 2: 127,427,566 F46S probably damaging Het
Klhl38 T A 15: 58,322,455 K293* probably null Het
Map4k4 T C 1: 40,014,188 I916T probably damaging Het
Nrap T A 19: 56,345,533 K964M probably damaging Het
Osbpl5 T C 7: 143,699,334 probably null Het
Perm1 A G 4: 156,217,779 Q260R probably benign Het
Ralgapb T A 2: 158,437,394 N133K possibly damaging Het
Slfn9 T C 11: 82,981,196 S905G probably benign Het
Ssh2 C T 11: 77,453,544 T785I probably damaging Het
Stk16 C A 1: 75,213,004 Q69K probably damaging Het
Stk36 T C 1: 74,622,287 L491P probably benign Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Tcp11 T C 17: 28,070,516 N194D probably damaging Het
Trio C A 15: 27,830,239 probably benign Het
Ugt2b1 A G 5: 86,921,991 V297A possibly damaging Het
Ugt2b5 T G 5: 87,137,232 H282P probably damaging Het
Usp53 A G 3: 122,933,843 M1030T probably damaging Het
Vmn1r234 T A 17: 21,229,703 I293N probably damaging Het
Vmn2r57 T A 7: 41,428,074 T223S probably benign Het
Wdr20 G T 12: 110,794,308 E543* probably null Het
Zcchc2 T C 1: 106,030,168 F790L probably damaging Het
Other mutations in Zbtb25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02321:Zbtb25 APN 12 76350133 missense probably damaging 0.99
R1298:Zbtb25 UTSW 12 76350001 missense probably benign 0.01
R1851:Zbtb25 UTSW 12 76349714 missense probably damaging 1.00
R1918:Zbtb25 UTSW 12 76349301 nonsense probably null
R2108:Zbtb25 UTSW 12 76350106 missense probably benign 0.29
R2209:Zbtb25 UTSW 12 76349129 makesense probably null
R5400:Zbtb25 UTSW 12 76349702 nonsense probably null
R5579:Zbtb25 UTSW 12 76349164 missense possibly damaging 0.94
R7570:Zbtb25 UTSW 12 76369592 unclassified probably benign
R8086:Zbtb25 UTSW 12 76349149 missense probably benign 0.27
R8910:Zbtb25 UTSW 12 76349134 missense probably damaging 1.00
R8965:Zbtb25 UTSW 12 76349803 missense probably benign 0.04
U24488:Zbtb25 UTSW 12 76349240 missense probably benign 0.05
Z1176:Zbtb25 UTSW 12 76349365 missense probably benign 0.01
Posted On 2016-08-02