Incidental Mutation 'IGL02995:Lrrn3'
ID 407098
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrn3
Ensembl Gene ENSMUSG00000036295
Gene Name leucine rich repeat protein 3, neuronal
Synonyms NLRR-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # IGL02995
Quality Score
Status
Chromosome 12
Chromosomal Location 41501667-41536056 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41502216 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 700 (I700M)
Ref Sequence ENSEMBL: ENSMUSP00000043818 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043884] [ENSMUST00000132121] [ENSMUST00000134965]
AlphaFold Q8CBC6
Predicted Effect probably damaging
Transcript: ENSMUST00000043884
AA Change: I700M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043818
Gene: ENSMUSG00000036295
AA Change: I700M

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
LRRNT 28 73 9.17e-4 SMART
LRR 115 138 2.63e0 SMART
LRR_TYP 139 162 1.5e-4 SMART
LRR 163 186 7.55e-1 SMART
LRR 187 210 1.76e1 SMART
LRR 211 234 1.62e1 SMART
LRR 235 258 5.11e0 SMART
LRR 260 282 3.18e1 SMART
LRR 333 356 4.44e0 SMART
LRRCT 368 420 3.7e-5 SMART
IGc2 435 503 5.04e-9 SMART
FN3 521 602 3.49e0 SMART
transmembrane domain 626 648 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132121
SMART Domains Protein: ENSMUSP00000118779
Gene: ENSMUSG00000056899

DomainStartEndE-ValueType
Pfam:Peptidase_S24 38 115 7.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134965
SMART Domains Protein: ENSMUSP00000116441
Gene: ENSMUSG00000056899

DomainStartEndE-ValueType
Pfam:Peptidase_S24 38 114 6.4e-11 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibited increased mean percent body fat and male homozygous mutant mice exhibited enhanced glucose tolerance when compared with controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A G 17: 48,470,456 (GRCm39) V175A probably benign Het
Adam19 G A 11: 46,027,176 (GRCm39) R603Q probably benign Het
Adam25 T C 8: 41,206,760 (GRCm39) S9P probably benign Het
Akr1e1 T A 13: 4,647,477 (GRCm39) probably benign Het
Ano8 C T 8: 71,935,761 (GRCm39) V286I possibly damaging Het
Baz1a C T 12: 54,947,232 (GRCm39) R1139H probably damaging Het
Brca2 T A 5: 150,452,953 (GRCm39) L29H probably damaging Het
Btaf1 T C 19: 36,958,535 (GRCm39) probably benign Het
C8b T A 4: 104,658,525 (GRCm39) probably benign Het
Cep295 A T 9: 15,244,608 (GRCm39) S1283T probably damaging Het
Cyp1a2 T C 9: 57,584,511 (GRCm39) *514W probably null Het
D2hgdh G T 1: 93,757,558 (GRCm39) D158Y probably damaging Het
Dennd1b G A 1: 139,008,980 (GRCm39) V228M probably damaging Het
Fgd6 T A 10: 93,881,342 (GRCm39) L732* probably null Het
Gm21969 G A 4: 139,335,009 (GRCm39) G348S probably benign Het
Gprc6a C T 10: 51,502,895 (GRCm39) V323M probably damaging Het
Gzme T A 14: 56,356,166 (GRCm39) M111L probably damaging Het
Iars2 G T 1: 185,035,498 (GRCm39) Q581K probably benign Het
Klra17 A T 6: 129,845,647 (GRCm39) probably null Het
Klra5 A T 6: 129,883,577 (GRCm39) D93E possibly damaging Het
Lats2 T C 14: 57,937,805 (GRCm39) Y228C probably damaging Het
Ltb A T 17: 35,414,348 (GRCm39) probably benign Het
Myo18b T C 5: 112,923,279 (GRCm39) probably benign Het
Or10a3 T A 7: 108,480,198 (GRCm39) E205V probably damaging Het
Or11l3 A G 11: 58,516,107 (GRCm39) M255T possibly damaging Het
Or12d13 A T 17: 37,647,600 (GRCm39) H174Q probably damaging Het
Or1e35 G A 11: 73,798,045 (GRCm39) T91M possibly damaging Het
Or1j17 C T 2: 36,578,644 (GRCm39) P210L possibly damaging Het
Pgap1 A C 1: 54,532,509 (GRCm39) I670S probably benign Het
Plxna4 A T 6: 32,493,530 (GRCm39) I362N probably damaging Het
Ppef2 C T 5: 92,383,759 (GRCm39) W450* probably null Het
Prr27 T C 5: 87,990,675 (GRCm39) S96P probably benign Het
Psip1 T A 4: 83,381,954 (GRCm39) probably benign Het
Rgs3 T A 4: 62,544,084 (GRCm39) H285Q possibly damaging Het
Ror1 T C 4: 100,191,722 (GRCm39) probably benign Het
Rps6ka5 C A 12: 100,540,258 (GRCm39) probably benign Het
Sipa1l1 T A 12: 82,404,105 (GRCm39) Y533N probably benign Het
Snx6 T C 12: 54,842,295 (GRCm39) probably benign Het
Tbc1d9 T A 8: 83,995,688 (GRCm39) probably null Het
Tek T C 4: 94,627,877 (GRCm39) probably benign Het
Tor2a T A 2: 32,651,509 (GRCm39) H241Q possibly damaging Het
Wnt5a A T 14: 28,244,871 (GRCm39) I353F probably benign Het
Other mutations in Lrrn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Lrrn3 APN 12 41,502,191 (GRCm39) intron probably benign
IGL02825:Lrrn3 APN 12 41,502,592 (GRCm39) missense probably damaging 1.00
IGL02927:Lrrn3 APN 12 41,503,343 (GRCm39) missense probably damaging 1.00
IGL02970:Lrrn3 APN 12 41,502,359 (GRCm39) missense probably benign
IGL02999:Lrrn3 APN 12 41,502,750 (GRCm39) missense probably benign 0.01
IGL03182:Lrrn3 APN 12 41,504,020 (GRCm39) missense probably damaging 1.00
IGL03280:Lrrn3 APN 12 41,504,146 (GRCm39) missense probably damaging 0.97
PIT4469001:Lrrn3 UTSW 12 41,503,017 (GRCm39) missense probably benign 0.03
R0167:Lrrn3 UTSW 12 41,504,014 (GRCm39) missense probably damaging 1.00
R0414:Lrrn3 UTSW 12 41,503,939 (GRCm39) missense probably damaging 1.00
R0787:Lrrn3 UTSW 12 41,504,230 (GRCm39) missense probably damaging 1.00
R0894:Lrrn3 UTSW 12 41,504,033 (GRCm39) missense probably damaging 1.00
R1433:Lrrn3 UTSW 12 41,502,583 (GRCm39) missense possibly damaging 0.74
R1610:Lrrn3 UTSW 12 41,502,992 (GRCm39) missense possibly damaging 0.89
R1834:Lrrn3 UTSW 12 41,503,517 (GRCm39) missense probably damaging 1.00
R2068:Lrrn3 UTSW 12 41,502,995 (GRCm39) missense probably damaging 1.00
R2871:Lrrn3 UTSW 12 41,502,722 (GRCm39) missense probably benign 0.00
R2871:Lrrn3 UTSW 12 41,502,722 (GRCm39) missense probably benign 0.00
R3771:Lrrn3 UTSW 12 41,502,869 (GRCm39) missense probably damaging 1.00
R4408:Lrrn3 UTSW 12 41,504,041 (GRCm39) missense probably benign 0.04
R4410:Lrrn3 UTSW 12 41,502,583 (GRCm39) missense possibly damaging 0.74
R4684:Lrrn3 UTSW 12 41,504,243 (GRCm39) missense possibly damaging 0.75
R4770:Lrrn3 UTSW 12 41,502,442 (GRCm39) missense probably benign 0.08
R4927:Lrrn3 UTSW 12 41,503,124 (GRCm39) missense probably damaging 1.00
R5037:Lrrn3 UTSW 12 41,503,594 (GRCm39) missense probably damaging 1.00
R5482:Lrrn3 UTSW 12 41,502,387 (GRCm39) missense probably damaging 0.96
R5482:Lrrn3 UTSW 12 41,502,386 (GRCm39) missense probably benign 0.01
R5667:Lrrn3 UTSW 12 41,502,297 (GRCm39) missense possibly damaging 0.77
R6022:Lrrn3 UTSW 12 41,503,429 (GRCm39) missense probably damaging 0.96
R6087:Lrrn3 UTSW 12 41,503,534 (GRCm39) missense possibly damaging 0.84
R6129:Lrrn3 UTSW 12 41,503,787 (GRCm39) nonsense probably null
R6309:Lrrn3 UTSW 12 41,503,205 (GRCm39) missense probably damaging 1.00
R7449:Lrrn3 UTSW 12 41,503,487 (GRCm39) missense probably damaging 1.00
R7555:Lrrn3 UTSW 12 41,502,910 (GRCm39) missense probably benign 0.01
R7560:Lrrn3 UTSW 12 41,502,712 (GRCm39) missense possibly damaging 0.93
R8059:Lrrn3 UTSW 12 41,504,216 (GRCm39) missense probably benign 0.22
R8134:Lrrn3 UTSW 12 41,503,047 (GRCm39) missense probably damaging 1.00
R8798:Lrrn3 UTSW 12 41,503,174 (GRCm39) missense possibly damaging 0.61
R9308:Lrrn3 UTSW 12 41,503,945 (GRCm39) missense probably damaging 1.00
R9318:Lrrn3 UTSW 12 41,503,243 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02