Incidental Mutation 'IGL02995:Ltb'
ID 407113
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ltb
Ensembl Gene ENSMUSG00000024399
Gene Name lymphotoxin B
Synonyms p33, Tnfc, lymphotoxin beta, LTbeta, Tnfsf3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL02995
Quality Score
Status
Chromosome 17
Chromosomal Location 35413483-35415281 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 35414348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134706 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025262] [ENSMUST00000025263] [ENSMUST00000167924] [ENSMUST00000173600]
AlphaFold P41155
Predicted Effect probably benign
Transcript: ENSMUST00000025262
SMART Domains Protein: ENSMUSP00000025262
Gene: ENSMUSG00000024399

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
low complexity region 72 85 N/A INTRINSIC
TNF 154 305 8.76e-42 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000025263
SMART Domains Protein: ENSMUSP00000025263
Gene: ENSMUSG00000024401

DomainStartEndE-ValueType
transmembrane domain 35 57 N/A INTRINSIC
TNF 91 235 1.59e-53 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167924
SMART Domains Protein: ENSMUSP00000126122
Gene: ENSMUSG00000024401

DomainStartEndE-ValueType
transmembrane domain 35 57 N/A INTRINSIC
TNF 74 219 2.8e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173510
Predicted Effect probably benign
Transcript: ENSMUST00000173600
SMART Domains Protein: ENSMUSP00000134706
Gene: ENSMUSG00000024399

DomainStartEndE-ValueType
TNF 33 184 8.76e-42 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183646
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations lack peripheral lymph nodes, Peyer's patches, splenic germinal centers and follicular dendritic cells. Mutants exhibit lymphocytosis in the circulation and peritoneal cavity with infiltrations of the lung and liver. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A G 17: 48,470,456 (GRCm39) V175A probably benign Het
Adam19 G A 11: 46,027,176 (GRCm39) R603Q probably benign Het
Adam25 T C 8: 41,206,760 (GRCm39) S9P probably benign Het
Akr1e1 T A 13: 4,647,477 (GRCm39) probably benign Het
Ano8 C T 8: 71,935,761 (GRCm39) V286I possibly damaging Het
Baz1a C T 12: 54,947,232 (GRCm39) R1139H probably damaging Het
Brca2 T A 5: 150,452,953 (GRCm39) L29H probably damaging Het
Btaf1 T C 19: 36,958,535 (GRCm39) probably benign Het
C8b T A 4: 104,658,525 (GRCm39) probably benign Het
Cep295 A T 9: 15,244,608 (GRCm39) S1283T probably damaging Het
Cyp1a2 T C 9: 57,584,511 (GRCm39) *514W probably null Het
D2hgdh G T 1: 93,757,558 (GRCm39) D158Y probably damaging Het
Dennd1b G A 1: 139,008,980 (GRCm39) V228M probably damaging Het
Fgd6 T A 10: 93,881,342 (GRCm39) L732* probably null Het
Gm21969 G A 4: 139,335,009 (GRCm39) G348S probably benign Het
Gprc6a C T 10: 51,502,895 (GRCm39) V323M probably damaging Het
Gzme T A 14: 56,356,166 (GRCm39) M111L probably damaging Het
Iars2 G T 1: 185,035,498 (GRCm39) Q581K probably benign Het
Klra17 A T 6: 129,845,647 (GRCm39) probably null Het
Klra5 A T 6: 129,883,577 (GRCm39) D93E possibly damaging Het
Lats2 T C 14: 57,937,805 (GRCm39) Y228C probably damaging Het
Lrrn3 T C 12: 41,502,216 (GRCm39) I700M probably damaging Het
Myo18b T C 5: 112,923,279 (GRCm39) probably benign Het
Or10a3 T A 7: 108,480,198 (GRCm39) E205V probably damaging Het
Or11l3 A G 11: 58,516,107 (GRCm39) M255T possibly damaging Het
Or12d13 A T 17: 37,647,600 (GRCm39) H174Q probably damaging Het
Or1e35 G A 11: 73,798,045 (GRCm39) T91M possibly damaging Het
Or1j17 C T 2: 36,578,644 (GRCm39) P210L possibly damaging Het
Pgap1 A C 1: 54,532,509 (GRCm39) I670S probably benign Het
Plxna4 A T 6: 32,493,530 (GRCm39) I362N probably damaging Het
Ppef2 C T 5: 92,383,759 (GRCm39) W450* probably null Het
Prr27 T C 5: 87,990,675 (GRCm39) S96P probably benign Het
Psip1 T A 4: 83,381,954 (GRCm39) probably benign Het
Rgs3 T A 4: 62,544,084 (GRCm39) H285Q possibly damaging Het
Ror1 T C 4: 100,191,722 (GRCm39) probably benign Het
Rps6ka5 C A 12: 100,540,258 (GRCm39) probably benign Het
Sipa1l1 T A 12: 82,404,105 (GRCm39) Y533N probably benign Het
Snx6 T C 12: 54,842,295 (GRCm39) probably benign Het
Tbc1d9 T A 8: 83,995,688 (GRCm39) probably null Het
Tek T C 4: 94,627,877 (GRCm39) probably benign Het
Tor2a T A 2: 32,651,509 (GRCm39) H241Q possibly damaging Het
Wnt5a A T 14: 28,244,871 (GRCm39) I353F probably benign Het
Other mutations in Ltb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Ltb APN 17 35,413,642 (GRCm39) missense possibly damaging 0.78
IGL01112:Ltb APN 17 35,413,576 (GRCm39) missense probably benign 0.04
IGL02263:Ltb APN 17 35,414,977 (GRCm39) missense probably damaging 1.00
IGL02983:Ltb APN 17 35,413,646 (GRCm39) missense probably benign 0.15
IGL03389:Ltb APN 17 35,414,044 (GRCm39) missense probably benign 0.00
R0103:Ltb UTSW 17 35,414,016 (GRCm39) intron probably benign
R0103:Ltb UTSW 17 35,414,016 (GRCm39) intron probably benign
R2060:Ltb UTSW 17 35,414,739 (GRCm39) missense probably damaging 0.97
R4718:Ltb UTSW 17 35,414,313 (GRCm39) splice site probably null
R4823:Ltb UTSW 17 35,414,206 (GRCm39) missense probably benign
R4884:Ltb UTSW 17 35,414,234 (GRCm39) missense probably benign
R5231:Ltb UTSW 17 35,414,802 (GRCm39) missense probably damaging 1.00
R5327:Ltb UTSW 17 35,414,935 (GRCm39) missense probably damaging 1.00
R8297:Ltb UTSW 17 35,413,655 (GRCm39) missense probably benign 0.00
R8344:Ltb UTSW 17 35,414,169 (GRCm39) missense probably benign 0.41
R9778:Ltb UTSW 17 35,414,906 (GRCm39) nonsense probably null
Posted On 2016-08-02