Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03000:Or6k8-ps1'

407269

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6k8-ps1

Ensembl Gene

ENSMUSG00000091950

Gene Name

olfactory receptor family 6 subfamily K member 8, pseudogene 1

Synonyms

Olfr421, Olfr422-ps1, GA_x6K02T2P20D-21002372-21001425, Olfr421-ps1, GA_x6K02T2P20D-21006310-21006124, MOR105-3

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL03000

Quality Score

Status

Chromosome

Chromosomal Location

173979047-173980096 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 173979126 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 15 (T15A)

Ref Sequence

ENSEMBL: ENSMUSP00000136689 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179386] [ENSMUST00000213748]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000179386
AA Change: T15A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000136689
Gene: ENSMUSG00000091950
AA Change: T15A

Domain	Start	End	E-Value	Type
low complexity region	25	38	N/A	INTRINSIC
Pfam:7tm_1	41	288	5.6e-29	PFAM
Pfam:7tm_4	139	285	4.7e-31	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213748

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,360,959 (GRCm39)	S445G	probably benign	Het
Abca5	C	T	11: 110,208,640 (GRCm39)	V226I	probably benign	Het
Ankrd34c	A	T	9: 89,611,239 (GRCm39)	D367E	probably benign	Het
Bmp6	G	T	13: 38,682,887 (GRCm39)		probably benign	Het
Cacna2d2	T	C	9: 107,401,397 (GRCm39)		probably null	Het
Cblb	T	G	16: 52,024,905 (GRCm39)	D933E	probably damaging	Het
Ccny	A	G	18: 9,353,489 (GRCm39)	S95P	probably benign	Het
Cep192	A	G	18: 67,985,115 (GRCm39)	I1658V	probably damaging	Het
Cntn6	A	T	6: 104,781,347 (GRCm39)	T478S	probably damaging	Het
Cpne7	T	C	8: 123,853,435 (GRCm39)	F247L	probably benign	Het
Csf1r	A	G	18: 61,242,724 (GRCm39)	E29G	probably damaging	Het
Dctn3	T	A	4: 41,719,912 (GRCm39)	I65F	possibly damaging	Het
Dock1	A	G	7: 134,390,969 (GRCm39)	E743G	probably benign	Het
Dus2	C	A	8: 106,775,316 (GRCm39)	T281N	probably damaging	Het
Gbx1	G	T	5: 24,709,924 (GRCm39)	T307K	probably benign	Het
Gtf2ird2	A	T	5: 134,223,745 (GRCm39)	N93I	probably benign	Het
Heatr1	A	G	13: 12,449,292 (GRCm39)	D1930G	probably damaging	Het
Hif3a	T	C	7: 16,782,564 (GRCm39)	I334V	probably benign	Het
Ints1	G	T	5: 139,752,261 (GRCm39)	N756K	probably benign	Het
Kcnn2	T	C	18: 45,693,635 (GRCm39)	F404L	probably damaging	Het
Kmt2c	G	A	5: 25,489,170 (GRCm39)	R4590W	probably damaging	Het
Limk1	A	T	5: 134,699,355 (GRCm39)	V134E	probably damaging	Het
Mep1a	A	G	17: 43,785,881 (GRCm39)	V736A	probably benign	Het
Mex3a	T	A	3: 88,443,602 (GRCm39)	I226N	probably damaging	Het
Mgl2	A	T	11: 70,025,026 (GRCm39)	K16*	probably null	Het
Mms22l	G	T	4: 24,581,161 (GRCm39)	V864L	probably damaging	Het
Mroh4	T	A	15: 74,487,963 (GRCm39)	M320L	probably benign	Het
Mylk3	G	A	8: 86,085,806 (GRCm39)	P243S	probably damaging	Het
Nbea	A	C	3: 55,912,048 (GRCm39)	D1246E	possibly damaging	Het
Ndnf	A	G	6: 65,680,299 (GRCm39)	T193A	possibly damaging	Het
Nfasc	T	C	1: 132,549,247 (GRCm39)		probably benign	Het
Ptprq	A	T	10: 107,378,518 (GRCm39)	F2008I	probably damaging	Het
Rhag	A	G	17: 41,139,413 (GRCm39)	K116R	probably benign	Het
Rictor	T	A	15: 6,798,721 (GRCm39)		probably benign	Het
Slc35f5	C	A	1: 125,502,479 (GRCm39)	T277N	probably damaging	Het
Sorcs2	A	G	5: 36,222,675 (GRCm39)		probably benign	Het
Ssh2	T	A	11: 77,312,032 (GRCm39)		probably benign	Het
Togaram2	T	C	17: 72,024,365 (GRCm39)	S830P	probably benign	Het
Trim30d	T	C	7: 104,122,476 (GRCm39)	T112A	probably benign	Het
Ttc34	T	C	4: 154,949,888 (GRCm39)	V947A	probably damaging	Het
Ttn	A	G	2: 76,642,953 (GRCm39)		probably benign	Het
Ubr5	A	T	15: 38,025,096 (GRCm39)	V560D	probably damaging	Het
Ush2a	A	T	1: 188,282,053 (GRCm39)	E1856V	possibly damaging	Het
Zfp142	T	C	1: 74,612,777 (GRCm39)	M457V	probably benign	Het
Zfp711	C	T	X: 111,534,555 (GRCm39)	Q137*	probably null	Het
Zkscan17	T	C	11: 59,377,986 (GRCm39)	Y399C	probably damaging	Het
Zswim6	T	G	13: 107,863,649 (GRCm39)		noncoding transcript	Het
Zswim6	T	A	13: 107,863,650 (GRCm39)		noncoding transcript	Het

Other mutations in Or6k8-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01994:Or6k8-ps1	APN	1	173,979,102 (GRCm39)	missense	probably benign	0.06
R0529:Or6k8-ps1	UTSW	1	173,979,696 (GRCm39)	missense	probably benign	0.01
R0574:Or6k8-ps1	UTSW	1	173,979,132 (GRCm39)	missense	probably benign	0.13
R1339:Or6k8-ps1	UTSW	1	173,979,777 (GRCm39)	missense	probably damaging	1.00
R1658:Or6k8-ps1	UTSW	1	173,979,789 (GRCm39)	missense	probably damaging	1.00
R1822:Or6k8-ps1	UTSW	1	173,979,780 (GRCm39)	missense	probably benign	0.20
R1991:Or6k8-ps1	UTSW	1	173,979,687 (GRCm39)	missense	probably damaging	1.00
R2391:Or6k8-ps1	UTSW	1	173,979,664 (GRCm39)	missense	probably benign	0.10
R4299:Or6k8-ps1	UTSW	1	173,979,878 (GRCm39)	nonsense	probably null
R4688:Or6k8-ps1	UTSW	1	173,979,162 (GRCm39)	missense	possibly damaging	0.81
R5241:Or6k8-ps1	UTSW	1	173,979,667 (GRCm39)	missense	probably benign	0.02
R5421:Or6k8-ps1	UTSW	1	173,979,861 (GRCm39)	nonsense	probably null

Posted On

2016-08-02