Incidental Mutation 'IGL03000:Zswim6'
ID407284
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zswim6
Ensembl Gene ENSMUSG00000032846
Gene Namezinc finger SWIM-type containing 6
Synonyms2900036G02Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.765) question?
Stock #IGL03000
Quality Score
Status
Chromosome13
Chromosomal Location107724618-107890064 bp(-) (GRCm38)
Type of Mutationexon
DNA Base Change (assembly) T to A at 107727115 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s):
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105097
SMART Domains Protein: ENSMUSP00000100724
Gene: ENSMUSG00000032846

DomainStartEndE-ValueType
low complexity region 19 39 N/A INTRINSIC
low complexity region 43 71 N/A INTRINSIC
low complexity region 132 193 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224719
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225197
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225822
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased striatal volume, abnormal medium spiny neuron morphology, and altered motor control including hyperactivity, impaired rotarod performance, repetitive movements, and behavioral hyperresponsiveness to amphetamine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,321,800 S445G probably benign Het
Abca5 C T 11: 110,317,814 V226I probably benign Het
Ankrd34c A T 9: 89,729,186 D367E probably benign Het
Bmp6 G T 13: 38,498,911 probably benign Het
Cacna2d2 T C 9: 107,524,198 probably null Het
Cblb T G 16: 52,204,542 D933E probably damaging Het
Ccny A G 18: 9,353,489 S95P probably benign Het
Cep192 A G 18: 67,852,044 I1658V probably damaging Het
Cntn6 A T 6: 104,804,386 T478S probably damaging Het
Cpne7 T C 8: 123,126,696 F247L probably benign Het
Csf1r A G 18: 61,109,652 E29G probably damaging Het
Dctn3 T A 4: 41,719,912 I65F possibly damaging Het
Dock1 A G 7: 134,789,240 E743G probably benign Het
Dus2 C A 8: 106,048,684 T281N probably damaging Het
Gbx1 G T 5: 24,504,926 T307K probably benign Het
Gtf2ird2 A T 5: 134,194,906 N93I probably benign Het
Heatr1 A G 13: 12,434,411 D1930G probably damaging Het
Hif3a T C 7: 17,048,639 I334V probably benign Het
Ints1 G T 5: 139,766,506 N756K probably benign Het
Kcnn2 T C 18: 45,560,568 F404L probably damaging Het
Kmt2c G A 5: 25,284,172 R4590W probably damaging Het
Limk1 A T 5: 134,670,501 V134E probably damaging Het
Mep1a A G 17: 43,474,990 V736A probably benign Het
Mex3a T A 3: 88,536,295 I226N probably damaging Het
Mgl2 A T 11: 70,134,200 K16* probably null Het
Mms22l G T 4: 24,581,161 V864L probably damaging Het
Mroh4 T A 15: 74,616,114 M320L probably benign Het
Mylk3 G A 8: 85,359,177 P243S probably damaging Het
Nbea A C 3: 56,004,627 D1246E possibly damaging Het
Ndnf A G 6: 65,703,315 T193A possibly damaging Het
Nfasc T C 1: 132,621,509 probably benign Het
Olfr421-ps1 A G 1: 174,151,560 T15A probably benign Het
Ptprq A T 10: 107,542,657 F2008I probably damaging Het
Rhag A G 17: 40,828,522 K116R probably benign Het
Rictor T A 15: 6,769,240 probably benign Het
Slc35f5 C A 1: 125,574,742 T277N probably damaging Het
Sorcs2 A G 5: 36,065,331 probably benign Het
Ssh2 T A 11: 77,421,206 probably benign Het
Togaram2 T C 17: 71,717,370 S830P probably benign Het
Trim30d T C 7: 104,473,269 T112A probably benign Het
Ttc34 T C 4: 154,865,431 V947A probably damaging Het
Ttn A G 2: 76,812,609 probably benign Het
Ubr5 A T 15: 38,024,852 V560D probably damaging Het
Ush2a A T 1: 188,549,856 E1856V possibly damaging Het
Zfp142 T C 1: 74,573,618 M457V probably benign Het
Zfp711 C T X: 112,624,858 Q137* probably null Het
Zkscan17 T C 11: 59,487,160 Y399C probably damaging Het
Other mutations in Zswim6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01670:Zswim6 APN 13 107728566 splice site noncoding transcript
IGL02367:Zswim6 APN 13 107744102 exon noncoding transcript
IGL02622:Zswim6 APN 13 107748251 exon noncoding transcript
IGL03000:Zswim6 APN 13 107727114 exon noncoding transcript
R0069:Zswim6 UTSW 13 107738563 exon noncoding transcript
R0069:Zswim6 UTSW 13 107738563 exon noncoding transcript
R0834:Zswim6 UTSW 13 107726454 exon noncoding transcript
R1080:Zswim6 UTSW 13 107787651 critical splice donor site noncoding transcript
R1542:Zswim6 UTSW 13 107727234 exon noncoding transcript
R2081:Zswim6 UTSW 13 107773395 exon noncoding transcript
R2133:Zswim6 UTSW 13 107743987 exon noncoding transcript
R3692:Zswim6 UTSW 13 107726541 exon noncoding transcript
R4323:Zswim6 UTSW 13 107889403 exon noncoding transcript
R4345:Zswim6 UTSW 13 107726931 exon noncoding transcript
R4369:Zswim6 UTSW 13 107726694 exon noncoding transcript
R5049:Zswim6 UTSW 13 107726575 exon noncoding transcript
R5111:Zswim6 UTSW 13 107728635 exon noncoding transcript
R5174:Zswim6 UTSW 13 107726681 exon noncoding transcript
R5531:Zswim6 UTSW 13 107769593 exon noncoding transcript
R5933:Zswim6 UTSW 13 107744107 exon noncoding transcript
R5934:Zswim6 UTSW 13 107744107 exon noncoding transcript
R6063:Zswim6 UTSW 13 107728577 exon noncoding transcript
R6168:Zswim6 UTSW 13 107787764 exon noncoding transcript
X0022:Zswim6 UTSW 13 107730324 exon noncoding transcript
Posted On2016-08-02