Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03000:Slc35f5'

407293

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35f5

Ensembl Gene

ENSMUSG00000026342

Gene Name

solute carrier family 35, member F5

Synonyms

1300003P13Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.172) question?

Stock #

IGL03000

Quality Score

Status

Chromosome

Chromosomal Location

125488332-125523557 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 125502479 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Asparagine at position 277 (T277N)

Ref Sequence

ENSEMBL: ENSMUSP00000027580 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027580]

AlphaFold

Q8R314

Predicted Effect

probably damaging
Transcript: ENSMUST00000027580
AA Change: T277N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000027580
Gene: ENSMUSG00000026342
AA Change: T277N

Domain	Start	End	E-Value	Type
low complexity region	8	27	N/A	INTRINSIC
transmembrane domain	69	86	N/A	INTRINSIC
transmembrane domain	101	120	N/A	INTRINSIC
Pfam:EamA	226	317	2.1e-8	PFAM
transmembrane domain	329	348	N/A	INTRINSIC
transmembrane domain	360	382	N/A	INTRINSIC
transmembrane domain	397	419	N/A	INTRINSIC
transmembrane domain	421	443	N/A	INTRINSIC
transmembrane domain	453	475	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,360,959 (GRCm39)	S445G	probably benign	Het
Abca5	C	T	11: 110,208,640 (GRCm39)	V226I	probably benign	Het
Ankrd34c	A	T	9: 89,611,239 (GRCm39)	D367E	probably benign	Het
Bmp6	G	T	13: 38,682,887 (GRCm39)		probably benign	Het
Cacna2d2	T	C	9: 107,401,397 (GRCm39)		probably null	Het
Cblb	T	G	16: 52,024,905 (GRCm39)	D933E	probably damaging	Het
Ccny	A	G	18: 9,353,489 (GRCm39)	S95P	probably benign	Het
Cep192	A	G	18: 67,985,115 (GRCm39)	I1658V	probably damaging	Het
Cntn6	A	T	6: 104,781,347 (GRCm39)	T478S	probably damaging	Het
Cpne7	T	C	8: 123,853,435 (GRCm39)	F247L	probably benign	Het
Csf1r	A	G	18: 61,242,724 (GRCm39)	E29G	probably damaging	Het
Dctn3	T	A	4: 41,719,912 (GRCm39)	I65F	possibly damaging	Het
Dock1	A	G	7: 134,390,969 (GRCm39)	E743G	probably benign	Het
Dus2	C	A	8: 106,775,316 (GRCm39)	T281N	probably damaging	Het
Gbx1	G	T	5: 24,709,924 (GRCm39)	T307K	probably benign	Het
Gtf2ird2	A	T	5: 134,223,745 (GRCm39)	N93I	probably benign	Het
Heatr1	A	G	13: 12,449,292 (GRCm39)	D1930G	probably damaging	Het
Hif3a	T	C	7: 16,782,564 (GRCm39)	I334V	probably benign	Het
Ints1	G	T	5: 139,752,261 (GRCm39)	N756K	probably benign	Het
Kcnn2	T	C	18: 45,693,635 (GRCm39)	F404L	probably damaging	Het
Kmt2c	G	A	5: 25,489,170 (GRCm39)	R4590W	probably damaging	Het
Limk1	A	T	5: 134,699,355 (GRCm39)	V134E	probably damaging	Het
Mep1a	A	G	17: 43,785,881 (GRCm39)	V736A	probably benign	Het
Mex3a	T	A	3: 88,443,602 (GRCm39)	I226N	probably damaging	Het
Mgl2	A	T	11: 70,025,026 (GRCm39)	K16*	probably null	Het
Mms22l	G	T	4: 24,581,161 (GRCm39)	V864L	probably damaging	Het
Mroh4	T	A	15: 74,487,963 (GRCm39)	M320L	probably benign	Het
Mylk3	G	A	8: 86,085,806 (GRCm39)	P243S	probably damaging	Het
Nbea	A	C	3: 55,912,048 (GRCm39)	D1246E	possibly damaging	Het
Ndnf	A	G	6: 65,680,299 (GRCm39)	T193A	possibly damaging	Het
Nfasc	T	C	1: 132,549,247 (GRCm39)		probably benign	Het
Or6k8-ps1	A	G	1: 173,979,126 (GRCm39)	T15A	probably benign	Het
Ptprq	A	T	10: 107,378,518 (GRCm39)	F2008I	probably damaging	Het
Rhag	A	G	17: 41,139,413 (GRCm39)	K116R	probably benign	Het
Rictor	T	A	15: 6,798,721 (GRCm39)		probably benign	Het
Sorcs2	A	G	5: 36,222,675 (GRCm39)		probably benign	Het
Ssh2	T	A	11: 77,312,032 (GRCm39)		probably benign	Het
Togaram2	T	C	17: 72,024,365 (GRCm39)	S830P	probably benign	Het
Trim30d	T	C	7: 104,122,476 (GRCm39)	T112A	probably benign	Het
Ttc34	T	C	4: 154,949,888 (GRCm39)	V947A	probably damaging	Het
Ttn	A	G	2: 76,642,953 (GRCm39)		probably benign	Het
Ubr5	A	T	15: 38,025,096 (GRCm39)	V560D	probably damaging	Het
Ush2a	A	T	1: 188,282,053 (GRCm39)	E1856V	possibly damaging	Het
Zfp142	T	C	1: 74,612,777 (GRCm39)	M457V	probably benign	Het
Zfp711	C	T	X: 111,534,555 (GRCm39)	Q137*	probably null	Het
Zkscan17	T	C	11: 59,377,986 (GRCm39)	Y399C	probably damaging	Het
Zswim6	T	G	13: 107,863,649 (GRCm39)		noncoding transcript	Het
Zswim6	T	A	13: 107,863,650 (GRCm39)		noncoding transcript	Het

Other mutations in Slc35f5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00662:Slc35f5	APN	1	125,515,161 (GRCm39)	missense	probably damaging	1.00
IGL01844:Slc35f5	APN	1	125,517,612 (GRCm39)	missense	probably damaging	0.96
IGL02218:Slc35f5	APN	1	125,512,292 (GRCm39)	missense	probably damaging	1.00
IGL02586:Slc35f5	APN	1	125,512,273 (GRCm39)	missense	probably damaging	1.00
IGL03160:Slc35f5	APN	1	125,502,472 (GRCm39)	missense	probably damaging	1.00
IGL03181:Slc35f5	APN	1	125,512,922 (GRCm39)	missense	probably damaging	1.00
IGL02984:Slc35f5	UTSW	1	125,490,250 (GRCm39)	missense	probably benign	0.28
R0127:Slc35f5	UTSW	1	125,503,942 (GRCm39)	missense	probably damaging	1.00
R0390:Slc35f5	UTSW	1	125,512,832 (GRCm39)	missense	probably damaging	1.00
R0513:Slc35f5	UTSW	1	125,503,906 (GRCm39)	splice site	probably benign
R1701:Slc35f5	UTSW	1	125,498,330 (GRCm39)	missense	possibly damaging	0.77
R1716:Slc35f5	UTSW	1	125,512,269 (GRCm39)	missense	possibly damaging	0.65
R2211:Slc35f5	UTSW	1	125,507,001 (GRCm39)	missense	possibly damaging	0.74
R3024:Slc35f5	UTSW	1	125,496,335 (GRCm39)	missense	probably benign	0.00
R3870:Slc35f5	UTSW	1	125,490,098 (GRCm39)	missense	probably benign	0.00
R4239:Slc35f5	UTSW	1	125,500,211 (GRCm39)	missense	possibly damaging	0.94
R4547:Slc35f5	UTSW	1	125,500,119 (GRCm39)	missense	probably benign	0.00
R5622:Slc35f5	UTSW	1	125,517,693 (GRCm39)	missense	probably damaging	1.00
R5688:Slc35f5	UTSW	1	125,518,775 (GRCm39)	missense	probably benign	0.23
R5876:Slc35f5	UTSW	1	125,515,100 (GRCm39)	critical splice acceptor site	probably null
R6701:Slc35f5	UTSW	1	125,490,347 (GRCm39)	missense	probably damaging	1.00
R7292:Slc35f5	UTSW	1	125,500,222 (GRCm39)	missense	probably damaging	0.99
R7368:Slc35f5	UTSW	1	125,512,256 (GRCm39)	missense	probably damaging	1.00
R7530:Slc35f5	UTSW	1	125,512,275 (GRCm39)	missense	probably damaging	1.00
R7807:Slc35f5	UTSW	1	125,512,278 (GRCm39)	missense	probably damaging	1.00
R8004:Slc35f5	UTSW	1	125,517,624 (GRCm39)	missense	probably damaging	0.98
R8289:Slc35f5	UTSW	1	125,490,252 (GRCm39)	nonsense	probably null
R8435:Slc35f5	UTSW	1	125,488,994 (GRCm39)	nonsense	probably null
R9011:Slc35f5	UTSW	1	125,490,050 (GRCm39)	missense	probably benign	0.03
R9339:Slc35f5	UTSW	1	125,517,628 (GRCm39)	missense	probably benign	0.34
R9365:Slc35f5	UTSW	1	125,496,333 (GRCm39)	missense	probably benign	0.08
Z1177:Slc35f5	UTSW	1	125,512,971 (GRCm39)	critical splice donor site	probably null
Z1177:Slc35f5	UTSW	1	125,488,442 (GRCm39)	start gained	probably benign

Posted On

2016-08-02