Incidental Mutation 'IGL03000:Mgl2'
ID 407300
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mgl2
Ensembl Gene ENSMUSG00000040950
Gene Name macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms CD301b
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03000
Quality Score
Status
Chromosome 11
Chromosomal Location 70021155-70028376 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 70025026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 16 (K16*)
Ref Sequence ENSEMBL: ENSMUSP00000131344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041550] [ENSMUST00000108584] [ENSMUST00000165951]
AlphaFold A9XX86
Predicted Effect probably null
Transcript: ENSMUST00000041550
AA Change: K16*
SMART Domains Protein: ENSMUSP00000048568
Gene: ENSMUSG00000040950
AA Change: K16*

DomainStartEndE-ValueType
Pfam:Lectin_N 6 179 4.6e-56 PFAM
CLECT 189 313 2.37e-35 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108584
AA Change: K10*
SMART Domains Protein: ENSMUSP00000104225
Gene: ENSMUSG00000040950
AA Change: K10*

DomainStartEndE-ValueType
Pfam:Lectin_N 8 173 8.6e-56 PFAM
CLECT 183 355 5.76e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118803
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132645
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147502
Predicted Effect probably null
Transcript: ENSMUST00000165951
AA Change: K16*
SMART Domains Protein: ENSMUSP00000131344
Gene: ENSMUSG00000040950
AA Change: K16*

DomainStartEndE-ValueType
Pfam:Lectin_N 21 133 2.1e-35 PFAM
Pfam:Lectin_N 129 180 5.4e-19 PFAM
CLECT 190 362 5.76e-25 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,360,959 (GRCm39) S445G probably benign Het
Abca5 C T 11: 110,208,640 (GRCm39) V226I probably benign Het
Ankrd34c A T 9: 89,611,239 (GRCm39) D367E probably benign Het
Bmp6 G T 13: 38,682,887 (GRCm39) probably benign Het
Cacna2d2 T C 9: 107,401,397 (GRCm39) probably null Het
Cblb T G 16: 52,024,905 (GRCm39) D933E probably damaging Het
Ccny A G 18: 9,353,489 (GRCm39) S95P probably benign Het
Cep192 A G 18: 67,985,115 (GRCm39) I1658V probably damaging Het
Cntn6 A T 6: 104,781,347 (GRCm39) T478S probably damaging Het
Cpne7 T C 8: 123,853,435 (GRCm39) F247L probably benign Het
Csf1r A G 18: 61,242,724 (GRCm39) E29G probably damaging Het
Dctn3 T A 4: 41,719,912 (GRCm39) I65F possibly damaging Het
Dock1 A G 7: 134,390,969 (GRCm39) E743G probably benign Het
Dus2 C A 8: 106,775,316 (GRCm39) T281N probably damaging Het
Gbx1 G T 5: 24,709,924 (GRCm39) T307K probably benign Het
Gtf2ird2 A T 5: 134,223,745 (GRCm39) N93I probably benign Het
Heatr1 A G 13: 12,449,292 (GRCm39) D1930G probably damaging Het
Hif3a T C 7: 16,782,564 (GRCm39) I334V probably benign Het
Ints1 G T 5: 139,752,261 (GRCm39) N756K probably benign Het
Kcnn2 T C 18: 45,693,635 (GRCm39) F404L probably damaging Het
Kmt2c G A 5: 25,489,170 (GRCm39) R4590W probably damaging Het
Limk1 A T 5: 134,699,355 (GRCm39) V134E probably damaging Het
Mep1a A G 17: 43,785,881 (GRCm39) V736A probably benign Het
Mex3a T A 3: 88,443,602 (GRCm39) I226N probably damaging Het
Mms22l G T 4: 24,581,161 (GRCm39) V864L probably damaging Het
Mroh4 T A 15: 74,487,963 (GRCm39) M320L probably benign Het
Mylk3 G A 8: 86,085,806 (GRCm39) P243S probably damaging Het
Nbea A C 3: 55,912,048 (GRCm39) D1246E possibly damaging Het
Ndnf A G 6: 65,680,299 (GRCm39) T193A possibly damaging Het
Nfasc T C 1: 132,549,247 (GRCm39) probably benign Het
Or6k8-ps1 A G 1: 173,979,126 (GRCm39) T15A probably benign Het
Ptprq A T 10: 107,378,518 (GRCm39) F2008I probably damaging Het
Rhag A G 17: 41,139,413 (GRCm39) K116R probably benign Het
Rictor T A 15: 6,798,721 (GRCm39) probably benign Het
Slc35f5 C A 1: 125,502,479 (GRCm39) T277N probably damaging Het
Sorcs2 A G 5: 36,222,675 (GRCm39) probably benign Het
Ssh2 T A 11: 77,312,032 (GRCm39) probably benign Het
Togaram2 T C 17: 72,024,365 (GRCm39) S830P probably benign Het
Trim30d T C 7: 104,122,476 (GRCm39) T112A probably benign Het
Ttc34 T C 4: 154,949,888 (GRCm39) V947A probably damaging Het
Ttn A G 2: 76,642,953 (GRCm39) probably benign Het
Ubr5 A T 15: 38,025,096 (GRCm39) V560D probably damaging Het
Ush2a A T 1: 188,282,053 (GRCm39) E1856V possibly damaging Het
Zfp142 T C 1: 74,612,777 (GRCm39) M457V probably benign Het
Zfp711 C T X: 111,534,555 (GRCm39) Q137* probably null Het
Zkscan17 T C 11: 59,377,986 (GRCm39) Y399C probably damaging Het
Zswim6 T G 13: 107,863,649 (GRCm39) noncoding transcript Het
Zswim6 T A 13: 107,863,650 (GRCm39) noncoding transcript Het
Other mutations in Mgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Mgl2 APN 11 70,027,932 (GRCm39) missense probably benign 0.33
IGL00757:Mgl2 APN 11 70,025,976 (GRCm39) missense probably damaging 1.00
IGL00838:Mgl2 APN 11 70,025,038 (GRCm39) missense probably benign 0.00
IGL01118:Mgl2 APN 11 70,025,015 (GRCm39) missense probably benign 0.00
IGL01613:Mgl2 APN 11 70,024,984 (GRCm39) missense probably benign 0.08
IGL02094:Mgl2 APN 11 70,027,923 (GRCm39) missense possibly damaging 0.73
R1893:Mgl2 UTSW 11 70,024,993 (GRCm39) splice site probably null
R3767:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3768:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3769:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R5467:Mgl2 UTSW 11 70,025,878 (GRCm39) missense possibly damaging 0.46
R5742:Mgl2 UTSW 11 70,027,510 (GRCm39) missense probably benign 0.00
R6018:Mgl2 UTSW 11 70,027,937 (GRCm39) makesense probably null
R7189:Mgl2 UTSW 11 70,027,869 (GRCm39) missense probably damaging 1.00
R7270:Mgl2 UTSW 11 70,026,506 (GRCm39) missense probably damaging 1.00
R7536:Mgl2 UTSW 11 70,027,833 (GRCm39) missense probably benign 0.02
R8330:Mgl2 UTSW 11 70,026,785 (GRCm39) missense probably benign 0.03
R9174:Mgl2 UTSW 11 70,026,606 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02