Incidental Mutation 'IGL03001:Or9s27'
ID 407314
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or9s27
Ensembl Gene ENSMUSG00000046300
Gene Name olfactory receptor family 9 subfamily S member 27
Synonyms MOR208-4, Olfr1412, GA_x6K02T2R7CC-81165686-81164721
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL03001
Quality Score
Status
Chromosome 1
Chromosomal Location 92516054-92517019 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 92516273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 74 (S74T)
Ref Sequence ENSEMBL: ENSMUSP00000150943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062964] [ENSMUST00000190505]
AlphaFold Q8VET3
Predicted Effect probably damaging
Transcript: ENSMUST00000062964
AA Change: S74T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060291
Gene: ENSMUSG00000046300
AA Change: S74T

DomainStartEndE-ValueType
transmembrane domain 10 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.8e-47 PFAM
Pfam:7tm_1 48 321 1.4e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000190505
AA Change: S74T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204141
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A C 7: 78,761,042 (GRCm39) D1918A probably damaging Het
Ahcy C A 2: 154,906,748 (GRCm39) D182Y probably damaging Het
Aldob T G 4: 49,542,844 (GRCm39) D110A probably damaging Het
Alkbh8 A T 9: 3,344,602 (GRCm39) M53L probably benign Het
Aqr T C 2: 113,977,400 (GRCm39) D363G probably benign Het
Asxl3 A G 18: 22,650,455 (GRCm39) R815G probably damaging Het
Atf4 T A 15: 80,140,858 (GRCm39) W83R probably damaging Het
Baz1a A T 12: 54,969,896 (GRCm39) M587K possibly damaging Het
Btbd8 T C 5: 107,645,708 (GRCm39) I9T probably damaging Het
Cactin T A 10: 81,161,568 (GRCm39) I700N probably damaging Het
Catsperg2 T C 7: 29,424,504 (GRCm39) S95G probably benign Het
Cd1d1 C T 3: 86,905,468 (GRCm39) S175N probably benign Het
Chd4 C A 6: 125,078,529 (GRCm39) A217E possibly damaging Het
Cnbd2 T C 2: 156,175,554 (GRCm39) probably null Het
Cntnap5c G A 17: 58,362,634 (GRCm39) C329Y probably damaging Het
Col12a1 C T 9: 79,540,955 (GRCm39) G2391R probably damaging Het
Col5a3 T A 9: 20,719,040 (GRCm39) D238V unknown Het
Cuedc1 T C 11: 88,073,315 (GRCm39) V160A probably benign Het
Depdc5 T C 5: 33,102,434 (GRCm39) V342A possibly damaging Het
Dnah6 T C 6: 73,126,123 (GRCm39) D1338G probably benign Het
Dpyd T C 3: 118,710,891 (GRCm39) V433A probably benign Het
Epb41l5 T C 1: 119,545,374 (GRCm39) H179R probably damaging Het
Fbf1 T C 11: 116,056,712 (GRCm39) probably benign Het
Flnb T C 14: 7,934,680 (GRCm38) S2251P probably damaging Het
Fsip2 A T 2: 82,820,968 (GRCm39) probably benign Het
Grin2b C T 6: 135,716,113 (GRCm39) V735M probably damaging Het
Itpr3 T G 17: 27,308,586 (GRCm39) probably benign Het
Lingo4 C T 3: 94,309,703 (GRCm39) R214C probably damaging Het
Lrp1b C T 2: 40,817,901 (GRCm39) R2329H probably damaging Het
Lrrc47 T C 4: 154,100,450 (GRCm39) L342P probably damaging Het
Mmp15 T C 8: 96,094,845 (GRCm39) S240P probably damaging Het
Ndufaf4 T A 4: 24,901,747 (GRCm39) N95K probably benign Het
Nms C T 1: 38,980,993 (GRCm39) P60S probably benign Het
Npas3 A T 12: 53,547,975 (GRCm39) Y77F probably damaging Het
Or2ak7 T G 11: 58,574,702 (GRCm39) M1R probably null Het
Or51f5 G T 7: 102,424,460 (GRCm39) C243F probably damaging Het
Or5d43 T A 2: 88,105,189 (GRCm39) D68V probably damaging Het
Or8d2b A G 9: 38,789,374 (GRCm39) M301V probably benign Het
Or9m2 T A 2: 87,820,493 (GRCm39) Y13N probably benign Het
Picalm T C 7: 89,831,454 (GRCm39) V429A probably benign Het
Pkhd1l1 T A 15: 44,421,400 (GRCm39) I3056N probably damaging Het
Pomt1 G T 2: 32,134,338 (GRCm39) M286I probably benign Het
Popdc2 A T 16: 38,189,881 (GRCm39) Y176F probably benign Het
Psg21 A T 7: 18,386,410 (GRCm39) M192K probably benign Het
Psma1 C A 7: 113,865,674 (GRCm39) A219S probably benign Het
Rad21l T G 2: 151,510,389 (GRCm39) H22P probably damaging Het
Rnf213 A G 11: 119,370,767 (GRCm39) T4791A probably damaging Het
Sdk2 A G 11: 113,712,452 (GRCm39) V1609A probably benign Het
Sema3e T A 5: 14,291,057 (GRCm39) S606T probably benign Het
Slc16a4 A T 3: 107,218,858 (GRCm39) R486S possibly damaging Het
Slc17a3 T C 13: 24,040,767 (GRCm39) L331P probably damaging Het
Slc38a11 A T 2: 65,184,159 (GRCm39) V164D probably damaging Het
Slc38a6 A G 12: 73,383,827 (GRCm39) I173V probably benign Het
Synpo2 T C 3: 122,873,604 (GRCm39) T1121A probably benign Het
Tfcp2 T C 15: 100,426,302 (GRCm39) D83G possibly damaging Het
Thnsl1 A G 2: 21,216,455 (GRCm39) T70A probably damaging Het
Tnfrsf21 A G 17: 43,398,786 (GRCm39) I631V probably damaging Het
Tor2a C A 2: 32,647,329 (GRCm39) H6Q possibly damaging Het
Ttn T C 2: 76,565,267 (GRCm39) N19993S probably benign Het
Vps53 T C 11: 76,029,150 (GRCm39) E119G probably damaging Het
Zkscan6 T C 11: 65,705,495 (GRCm39) W69R probably damaging Het
Zng1 T C 19: 24,900,002 (GRCm39) K301E probably benign Het
Zswim8 T C 14: 20,764,459 (GRCm39) S610P probably damaging Het
Other mutations in Or9s27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Or9s27 APN 1 92,516,694 (GRCm39) missense possibly damaging 0.52
IGL02177:Or9s27 APN 1 92,516,479 (GRCm39) missense possibly damaging 0.96
IGL02507:Or9s27 APN 1 92,516,648 (GRCm39) missense possibly damaging 0.68
IGL02888:Or9s27 APN 1 92,516,925 (GRCm39) missense probably damaging 1.00
R1771:Or9s27 UTSW 1 92,516,837 (GRCm39) missense probably benign 0.03
R1780:Or9s27 UTSW 1 92,516,111 (GRCm39) missense probably benign 0.01
R2215:Or9s27 UTSW 1 92,516,708 (GRCm39) missense probably benign 0.00
R2437:Or9s27 UTSW 1 92,516,688 (GRCm39) missense possibly damaging 0.46
R3176:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3177:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3276:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3277:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R4475:Or9s27 UTSW 1 92,516,301 (GRCm39) missense probably benign 0.00
R4892:Or9s27 UTSW 1 92,516,643 (GRCm39) missense probably benign 0.05
R5910:Or9s27 UTSW 1 92,516,429 (GRCm39) missense probably damaging 1.00
R6808:Or9s27 UTSW 1 92,516,768 (GRCm39) missense probably damaging 0.99
R7130:Or9s27 UTSW 1 92,516,634 (GRCm39) missense probably benign 0.10
R7476:Or9s27 UTSW 1 92,516,986 (GRCm39) missense probably benign
R9695:Or9s27 UTSW 1 92,516,595 (GRCm39) missense probably benign 0.01
Z1088:Or9s27 UTSW 1 92,516,273 (GRCm39) missense probably damaging 1.00
Z1177:Or9s27 UTSW 1 92,516,100 (GRCm39) nonsense probably null
Posted On 2016-08-02