Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03001:Or8d2b'

407325

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8d2b

Ensembl Gene

ENSMUSG00000064333

Gene Name

olfactory receptor family 8 subfamily D member 2D

Synonyms

MOR171-8, Olfr926, GA_x6K02T2PVTD-32573036-32573962

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL03001

Quality Score

Status

Chromosome

Chromosomal Location

38788474-38789400 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 38789374 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 301 (M301V)

Ref Sequence

ENSEMBL: ENSMUSP00000077405 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078289]

AlphaFold

Q9EQ98

Predicted Effect

probably benign
Transcript: ENSMUST00000078289
AA Change: M301V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000077405
Gene: ENSMUSG00000064333
AA Change: M301V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	305	2.9e-53	PFAM
Pfam:7TM_GPCR_Srsx	32	282	8.6e-7	PFAM
Pfam:7tm_1	38	287	1.6e-20	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	C	7: 78,761,042 (GRCm39)	D1918A	probably damaging	Het
Ahcy	C	A	2: 154,906,748 (GRCm39)	D182Y	probably damaging	Het
Aldob	T	G	4: 49,542,844 (GRCm39)	D110A	probably damaging	Het
Alkbh8	A	T	9: 3,344,602 (GRCm39)	M53L	probably benign	Het
Aqr	T	C	2: 113,977,400 (GRCm39)	D363G	probably benign	Het
Asxl3	A	G	18: 22,650,455 (GRCm39)	R815G	probably damaging	Het
Atf4	T	A	15: 80,140,858 (GRCm39)	W83R	probably damaging	Het
Baz1a	A	T	12: 54,969,896 (GRCm39)	M587K	possibly damaging	Het
Btbd8	T	C	5: 107,645,708 (GRCm39)	I9T	probably damaging	Het
Cactin	T	A	10: 81,161,568 (GRCm39)	I700N	probably damaging	Het
Catsperg2	T	C	7: 29,424,504 (GRCm39)	S95G	probably benign	Het
Cd1d1	C	T	3: 86,905,468 (GRCm39)	S175N	probably benign	Het
Chd4	C	A	6: 125,078,529 (GRCm39)	A217E	possibly damaging	Het
Cnbd2	T	C	2: 156,175,554 (GRCm39)		probably null	Het
Cntnap5c	G	A	17: 58,362,634 (GRCm39)	C329Y	probably damaging	Het
Col12a1	C	T	9: 79,540,955 (GRCm39)	G2391R	probably damaging	Het
Col5a3	T	A	9: 20,719,040 (GRCm39)	D238V	unknown	Het
Cuedc1	T	C	11: 88,073,315 (GRCm39)	V160A	probably benign	Het
Depdc5	T	C	5: 33,102,434 (GRCm39)	V342A	possibly damaging	Het
Dnah6	T	C	6: 73,126,123 (GRCm39)	D1338G	probably benign	Het
Dpyd	T	C	3: 118,710,891 (GRCm39)	V433A	probably benign	Het
Epb41l5	T	C	1: 119,545,374 (GRCm39)	H179R	probably damaging	Het
Fbf1	T	C	11: 116,056,712 (GRCm39)		probably benign	Het
Flnb	T	C	14: 7,934,680 (GRCm38)	S2251P	probably damaging	Het
Fsip2	A	T	2: 82,820,968 (GRCm39)		probably benign	Het
Grin2b	C	T	6: 135,716,113 (GRCm39)	V735M	probably damaging	Het
Itpr3	T	G	17: 27,308,586 (GRCm39)		probably benign	Het
Lingo4	C	T	3: 94,309,703 (GRCm39)	R214C	probably damaging	Het
Lrp1b	C	T	2: 40,817,901 (GRCm39)	R2329H	probably damaging	Het
Lrrc47	T	C	4: 154,100,450 (GRCm39)	L342P	probably damaging	Het
Mmp15	T	C	8: 96,094,845 (GRCm39)	S240P	probably damaging	Het
Ndufaf4	T	A	4: 24,901,747 (GRCm39)	N95K	probably benign	Het
Nms	C	T	1: 38,980,993 (GRCm39)	P60S	probably benign	Het
Npas3	A	T	12: 53,547,975 (GRCm39)	Y77F	probably damaging	Het
Or2ak7	T	G	11: 58,574,702 (GRCm39)	M1R	probably null	Het
Or51f5	G	T	7: 102,424,460 (GRCm39)	C243F	probably damaging	Het
Or5d43	T	A	2: 88,105,189 (GRCm39)	D68V	probably damaging	Het
Or9m2	T	A	2: 87,820,493 (GRCm39)	Y13N	probably benign	Het
Or9s27	T	A	1: 92,516,273 (GRCm39)	S74T	probably damaging	Het
Picalm	T	C	7: 89,831,454 (GRCm39)	V429A	probably benign	Het
Pkhd1l1	T	A	15: 44,421,400 (GRCm39)	I3056N	probably damaging	Het
Pomt1	G	T	2: 32,134,338 (GRCm39)	M286I	probably benign	Het
Popdc2	A	T	16: 38,189,881 (GRCm39)	Y176F	probably benign	Het
Psg21	A	T	7: 18,386,410 (GRCm39)	M192K	probably benign	Het
Psma1	C	A	7: 113,865,674 (GRCm39)	A219S	probably benign	Het
Rad21l	T	G	2: 151,510,389 (GRCm39)	H22P	probably damaging	Het
Rnf213	A	G	11: 119,370,767 (GRCm39)	T4791A	probably damaging	Het
Sdk2	A	G	11: 113,712,452 (GRCm39)	V1609A	probably benign	Het
Sema3e	T	A	5: 14,291,057 (GRCm39)	S606T	probably benign	Het
Slc16a4	A	T	3: 107,218,858 (GRCm39)	R486S	possibly damaging	Het
Slc17a3	T	C	13: 24,040,767 (GRCm39)	L331P	probably damaging	Het
Slc38a11	A	T	2: 65,184,159 (GRCm39)	V164D	probably damaging	Het
Slc38a6	A	G	12: 73,383,827 (GRCm39)	I173V	probably benign	Het
Synpo2	T	C	3: 122,873,604 (GRCm39)	T1121A	probably benign	Het
Tfcp2	T	C	15: 100,426,302 (GRCm39)	D83G	possibly damaging	Het
Thnsl1	A	G	2: 21,216,455 (GRCm39)	T70A	probably damaging	Het
Tnfrsf21	A	G	17: 43,398,786 (GRCm39)	I631V	probably damaging	Het
Tor2a	C	A	2: 32,647,329 (GRCm39)	H6Q	possibly damaging	Het
Ttn	T	C	2: 76,565,267 (GRCm39)	N19993S	probably benign	Het
Vps53	T	C	11: 76,029,150 (GRCm39)	E119G	probably damaging	Het
Zkscan6	T	C	11: 65,705,495 (GRCm39)	W69R	probably damaging	Het
Zng1	T	C	19: 24,900,002 (GRCm39)	K301E	probably benign	Het
Zswim8	T	C	14: 20,764,459 (GRCm39)	S610P	probably damaging	Het

Other mutations in Or8d2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01886:Or8d2b	APN	9	38,788,844 (GRCm39)	missense	probably damaging	0.97
IGL02315:Or8d2b	APN	9	38,789,353 (GRCm39)	missense	probably damaging	1.00
IGL02626:Or8d2b	APN	9	38,788,784 (GRCm39)	missense	probably benign	0.05
IGL03085:Or8d2b	APN	9	38,788,959 (GRCm39)	missense	probably benign
R0365:Or8d2b	UTSW	9	38,788,481 (GRCm39)	missense	probably benign	0.00
R0600:Or8d2b	UTSW	9	38,789,111 (GRCm39)	missense	probably damaging	0.99
R0708:Or8d2b	UTSW	9	38,788,571 (GRCm39)	missense	probably damaging	0.97
R1178:Or8d2b	UTSW	9	38,789,051 (GRCm39)	missense	probably damaging	1.00
R1762:Or8d2b	UTSW	9	38,789,081 (GRCm39)	missense	probably damaging	0.98
R1856:Or8d2b	UTSW	9	38,788,892 (GRCm39)	missense	possibly damaging	0.58
R1924:Or8d2b	UTSW	9	38,789,147 (GRCm39)	missense	probably damaging	1.00
R2267:Or8d2b	UTSW	9	38,789,359 (GRCm39)	missense	probably benign	0.00
R3729:Or8d2b	UTSW	9	38,788,547 (GRCm39)	missense	probably damaging	1.00
R4290:Or8d2b	UTSW	9	38,788,609 (GRCm39)	missense	probably damaging	1.00
R4292:Or8d2b	UTSW	9	38,788,609 (GRCm39)	missense	probably damaging	1.00
R4293:Or8d2b	UTSW	9	38,788,609 (GRCm39)	missense	probably damaging	1.00
R4295:Or8d2b	UTSW	9	38,788,609 (GRCm39)	missense	probably damaging	1.00
R4973:Or8d2b	UTSW	9	38,789,400 (GRCm39)	makesense	probably null
R5026:Or8d2b	UTSW	9	38,789,195 (GRCm39)	missense	possibly damaging	0.95
R5086:Or8d2b	UTSW	9	38,789,087 (GRCm39)	missense	probably damaging	1.00
R5103:Or8d2b	UTSW	9	38,788,872 (GRCm39)	missense	probably damaging	1.00
R5817:Or8d2b	UTSW	9	38,788,673 (GRCm39)	missense	probably damaging	1.00
R5998:Or8d2b	UTSW	9	38,789,165 (GRCm39)	missense	probably damaging	0.99
R6101:Or8d2b	UTSW	9	38,788,604 (GRCm39)	missense	possibly damaging	0.95
R6105:Or8d2b	UTSW	9	38,788,604 (GRCm39)	missense	possibly damaging	0.95
R6176:Or8d2b	UTSW	9	38,788,673 (GRCm39)	missense	probably damaging	1.00
R6403:Or8d2b	UTSW	9	38,788,538 (GRCm39)	missense	probably damaging	0.97
R8116:Or8d2b	UTSW	9	38,789,026 (GRCm39)	missense	probably damaging	0.98
R8144:Or8d2b	UTSW	9	38,788,662 (GRCm39)	missense	probably damaging	1.00
R8972:Or8d2b	UTSW	9	38,789,150 (GRCm39)	missense	probably benign	0.00
R9520:Or8d2b	UTSW	9	38,789,039 (GRCm39)	missense	probably benign	0.22
R9550:Or8d2b	UTSW	9	38,788,937 (GRCm39)	missense	probably benign	0.00
R9614:Or8d2b	UTSW	9	38,789,281 (GRCm39)	missense	probably damaging	0.98
RF014:Or8d2b	UTSW	9	38,789,196 (GRCm39)	missense	probably benign	0.14
X0022:Or8d2b	UTSW	9	38,788,952 (GRCm39)	missense	possibly damaging	0.84

Posted On

2016-08-02