Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03001:Lingo4'

407353

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lingo4

Ensembl Gene

ENSMUSG00000044505

Gene Name

leucine rich repeat and Ig domain containing 4

Synonyms

LERN4, Lrrn6d, A530050P17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL03001

Quality Score

Status

Chromosome

Chromosomal Location

94306526-94311820 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 94309703 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Cysteine at position 214 (R214C)

Ref Sequence

ENSEMBL: ENSMUSP00000058050 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029795] [ENSMUST00000050975] [ENSMUST00000197040] [ENSMUST00000200009]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000029795

SMART Domains

Protein: ENSMUSP00000029795
Gene: ENSMUSG00000028150

Domain	Start	End	E-Value	Type
ZnF_C4	28	99	7.2e-37	SMART
low complexity region	116	133	N/A	INTRINSIC
HOLI	320	474	3.78e-22	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000050975
AA Change: R214C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058050
Gene: ENSMUSG00000044505
AA Change: R214C

Domain	Start	End	E-Value	Type
LRRNT	55	89	1.23e-4	SMART
LRR	88	107	2.76e2	SMART
LRR_TYP	108	131	1.02e-6	SMART
LRR_TYP	132	155	7.26e-3	SMART
LRR	156	179	1.33e1	SMART
LRR_TYP	180	203	5.42e-2	SMART
LRR	204	227	4.45e1	SMART
LRR	228	251	3.27e1	SMART
LRR	300	323	4.83e0	SMART
LRR	324	347	3.07e-1	SMART
LRR	348	371	3.36e1	SMART
LRRCT	383	436	5.24e-5	SMART
IGc2	451	516	3.53e-13	SMART
transmembrane domain	560	582	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000197040

SMART Domains

Protein: ENSMUSP00000143763
Gene: ENSMUSG00000028150

Domain	Start	End	E-Value	Type
ZnF_C4	7	78	7.2e-37	SMART
low complexity region	95	112	N/A	INTRINSIC
HOLI	299	453	3.78e-22	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198793

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198829

Predicted Effect

probably benign
Transcript: ENSMUST00000200009

SMART Domains

Protein: ENSMUSP00000143610
Gene: ENSMUSG00000028150

Domain	Start	End	E-Value	Type
ZnF_C4	13	84	7.2e-37	SMART
low complexity region	101	118	N/A	INTRINSIC
PDB:3L0L\|B	243	309	1e-22	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	C	7: 78,761,042 (GRCm39)	D1918A	probably damaging	Het
Ahcy	C	A	2: 154,906,748 (GRCm39)	D182Y	probably damaging	Het
Aldob	T	G	4: 49,542,844 (GRCm39)	D110A	probably damaging	Het
Alkbh8	A	T	9: 3,344,602 (GRCm39)	M53L	probably benign	Het
Aqr	T	C	2: 113,977,400 (GRCm39)	D363G	probably benign	Het
Asxl3	A	G	18: 22,650,455 (GRCm39)	R815G	probably damaging	Het
Atf4	T	A	15: 80,140,858 (GRCm39)	W83R	probably damaging	Het
Baz1a	A	T	12: 54,969,896 (GRCm39)	M587K	possibly damaging	Het
Btbd8	T	C	5: 107,645,708 (GRCm39)	I9T	probably damaging	Het
Cactin	T	A	10: 81,161,568 (GRCm39)	I700N	probably damaging	Het
Catsperg2	T	C	7: 29,424,504 (GRCm39)	S95G	probably benign	Het
Cd1d1	C	T	3: 86,905,468 (GRCm39)	S175N	probably benign	Het
Chd4	C	A	6: 125,078,529 (GRCm39)	A217E	possibly damaging	Het
Cnbd2	T	C	2: 156,175,554 (GRCm39)		probably null	Het
Cntnap5c	G	A	17: 58,362,634 (GRCm39)	C329Y	probably damaging	Het
Col12a1	C	T	9: 79,540,955 (GRCm39)	G2391R	probably damaging	Het
Col5a3	T	A	9: 20,719,040 (GRCm39)	D238V	unknown	Het
Cuedc1	T	C	11: 88,073,315 (GRCm39)	V160A	probably benign	Het
Depdc5	T	C	5: 33,102,434 (GRCm39)	V342A	possibly damaging	Het
Dnah6	T	C	6: 73,126,123 (GRCm39)	D1338G	probably benign	Het
Dpyd	T	C	3: 118,710,891 (GRCm39)	V433A	probably benign	Het
Epb41l5	T	C	1: 119,545,374 (GRCm39)	H179R	probably damaging	Het
Fbf1	T	C	11: 116,056,712 (GRCm39)		probably benign	Het
Flnb	T	C	14: 7,934,680 (GRCm38)	S2251P	probably damaging	Het
Fsip2	A	T	2: 82,820,968 (GRCm39)		probably benign	Het
Grin2b	C	T	6: 135,716,113 (GRCm39)	V735M	probably damaging	Het
Itpr3	T	G	17: 27,308,586 (GRCm39)		probably benign	Het
Lrp1b	C	T	2: 40,817,901 (GRCm39)	R2329H	probably damaging	Het
Lrrc47	T	C	4: 154,100,450 (GRCm39)	L342P	probably damaging	Het
Mmp15	T	C	8: 96,094,845 (GRCm39)	S240P	probably damaging	Het
Ndufaf4	T	A	4: 24,901,747 (GRCm39)	N95K	probably benign	Het
Nms	C	T	1: 38,980,993 (GRCm39)	P60S	probably benign	Het
Npas3	A	T	12: 53,547,975 (GRCm39)	Y77F	probably damaging	Het
Or2ak7	T	G	11: 58,574,702 (GRCm39)	M1R	probably null	Het
Or51f5	G	T	7: 102,424,460 (GRCm39)	C243F	probably damaging	Het
Or5d43	T	A	2: 88,105,189 (GRCm39)	D68V	probably damaging	Het
Or8d2b	A	G	9: 38,789,374 (GRCm39)	M301V	probably benign	Het
Or9m2	T	A	2: 87,820,493 (GRCm39)	Y13N	probably benign	Het
Or9s27	T	A	1: 92,516,273 (GRCm39)	S74T	probably damaging	Het
Picalm	T	C	7: 89,831,454 (GRCm39)	V429A	probably benign	Het
Pkhd1l1	T	A	15: 44,421,400 (GRCm39)	I3056N	probably damaging	Het
Pomt1	G	T	2: 32,134,338 (GRCm39)	M286I	probably benign	Het
Popdc2	A	T	16: 38,189,881 (GRCm39)	Y176F	probably benign	Het
Psg21	A	T	7: 18,386,410 (GRCm39)	M192K	probably benign	Het
Psma1	C	A	7: 113,865,674 (GRCm39)	A219S	probably benign	Het
Rad21l	T	G	2: 151,510,389 (GRCm39)	H22P	probably damaging	Het
Rnf213	A	G	11: 119,370,767 (GRCm39)	T4791A	probably damaging	Het
Sdk2	A	G	11: 113,712,452 (GRCm39)	V1609A	probably benign	Het
Sema3e	T	A	5: 14,291,057 (GRCm39)	S606T	probably benign	Het
Slc16a4	A	T	3: 107,218,858 (GRCm39)	R486S	possibly damaging	Het
Slc17a3	T	C	13: 24,040,767 (GRCm39)	L331P	probably damaging	Het
Slc38a11	A	T	2: 65,184,159 (GRCm39)	V164D	probably damaging	Het
Slc38a6	A	G	12: 73,383,827 (GRCm39)	I173V	probably benign	Het
Synpo2	T	C	3: 122,873,604 (GRCm39)	T1121A	probably benign	Het
Tfcp2	T	C	15: 100,426,302 (GRCm39)	D83G	possibly damaging	Het
Thnsl1	A	G	2: 21,216,455 (GRCm39)	T70A	probably damaging	Het
Tnfrsf21	A	G	17: 43,398,786 (GRCm39)	I631V	probably damaging	Het
Tor2a	C	A	2: 32,647,329 (GRCm39)	H6Q	possibly damaging	Het
Ttn	T	C	2: 76,565,267 (GRCm39)	N19993S	probably benign	Het
Vps53	T	C	11: 76,029,150 (GRCm39)	E119G	probably damaging	Het
Zkscan6	T	C	11: 65,705,495 (GRCm39)	W69R	probably damaging	Het
Zng1	T	C	19: 24,900,002 (GRCm39)	K301E	probably benign	Het
Zswim8	T	C	14: 20,764,459 (GRCm39)	S610P	probably damaging	Het

Other mutations in Lingo4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01074:Lingo4	APN	3	94,310,595 (GRCm39)	missense	probably benign	0.00
IGL02662:Lingo4	APN	3	94,309,124 (GRCm39)	unclassified	probably benign
IGL02687:Lingo4	APN	3	94,309,404 (GRCm39)	missense	probably damaging	1.00
IGL02711:Lingo4	APN	3	94,310,700 (GRCm39)	missense	probably benign
IGL03260:Lingo4	APN	3	94,309,250 (GRCm39)	missense	probably benign
PIT4449001:Lingo4	UTSW	3	94,309,239 (GRCm39)	missense	probably benign
R0088:Lingo4	UTSW	3	94,309,340 (GRCm39)	missense	probably benign	0.39
R0616:Lingo4	UTSW	3	94,310,388 (GRCm39)	missense	probably benign	0.00
R1455:Lingo4	UTSW	3	94,306,699 (GRCm39)	unclassified	probably benign
R1733:Lingo4	UTSW	3	94,310,485 (GRCm39)	missense	probably benign	0.00
R2001:Lingo4	UTSW	3	94,310,382 (GRCm39)	missense	probably damaging	1.00
R2085:Lingo4	UTSW	3	94,309,552 (GRCm39)	missense	probably damaging	1.00
R3793:Lingo4	UTSW	3	94,309,685 (GRCm39)	missense	probably benign
R3805:Lingo4	UTSW	3	94,309,407 (GRCm39)	missense	probably damaging	1.00
R3806:Lingo4	UTSW	3	94,309,407 (GRCm39)	missense	probably damaging	1.00
R4438:Lingo4	UTSW	3	94,310,204 (GRCm39)	missense	possibly damaging	0.79
R4660:Lingo4	UTSW	3	94,310,672 (GRCm39)	missense	probably benign	0.00
R4724:Lingo4	UTSW	3	94,310,183 (GRCm39)	nonsense	probably null
R4981:Lingo4	UTSW	3	94,306,761 (GRCm39)	missense	probably benign	0.18
R4994:Lingo4	UTSW	3	94,310,308 (GRCm39)	missense	probably benign	0.02
R4994:Lingo4	UTSW	3	94,309,848 (GRCm39)	missense	probably benign
R5600:Lingo4	UTSW	3	94,309,220 (GRCm39)	missense	probably benign
R6188:Lingo4	UTSW	3	94,310,157 (GRCm39)	missense	probably damaging	1.00
R6267:Lingo4	UTSW	3	94,310,697 (GRCm39)	missense	probably benign	0.02
R6303:Lingo4	UTSW	3	94,310,513 (GRCm39)	missense	probably damaging	1.00
R6304:Lingo4	UTSW	3	94,310,513 (GRCm39)	missense	probably damaging	1.00
R6789:Lingo4	UTSW	3	94,306,662 (GRCm39)	unclassified	probably benign
R7313:Lingo4	UTSW	3	94,310,451 (GRCm39)	missense	possibly damaging	0.95
R7329:Lingo4	UTSW	3	94,310,162 (GRCm39)	missense	probably benign
R7631:Lingo4	UTSW	3	94,306,767 (GRCm39)	missense	possibly damaging	0.93
R7908:Lingo4	UTSW	3	94,309,541 (GRCm39)	missense	probably benign	0.19
R8277:Lingo4	UTSW	3	94,309,931 (GRCm39)	missense	possibly damaging	0.61
R8848:Lingo4	UTSW	3	94,310,840 (GRCm39)	missense	probably benign
R9257:Lingo4	UTSW	3	94,310,676 (GRCm39)	missense	probably benign	0.05
R9753:Lingo4	UTSW	3	94,309,493 (GRCm39)	nonsense	probably null
X0054:Lingo4	UTSW	3	94,310,683 (GRCm39)	missense	possibly damaging	0.54
Z1177:Lingo4	UTSW	3	94,310,301 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02