Incidental Mutation 'IGL03002:Dapk3'
ID407377
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dapk3
Ensembl Gene ENSMUSG00000034974
Gene Namedeath-associated protein kinase 3
SynonymsZIP kinase
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL03002
Quality Score
Status
Chromosome10
Chromosomal Location81183005-81193197 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to T at 81190603 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 187 (E187*)
Ref Sequence ENSEMBL: ENSMUSP00000151577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047665] [ENSMUST00000178422] [ENSMUST00000218157] [ENSMUST00000219133] [ENSMUST00000219850]
Predicted Effect probably null
Transcript: ENSMUST00000047665
AA Change: E187*
SMART Domains Protein: ENSMUSP00000035962
Gene: ENSMUSG00000034974
AA Change: E187*

DomainStartEndE-ValueType
S_TKc 13 275 1.93e-98 SMART
low complexity region 288 299 N/A INTRINSIC
low complexity region 331 347 N/A INTRINSIC
low complexity region 349 411 N/A INTRINSIC
coiled coil region 419 444 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129834
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129950
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150782
Predicted Effect probably null
Transcript: ENSMUST00000178422
AA Change: E187*
SMART Domains Protein: ENSMUSP00000137333
Gene: ENSMUSG00000034974
AA Change: E187*

DomainStartEndE-ValueType
S_TKc 13 275 1.93e-98 SMART
low complexity region 288 299 N/A INTRINSIC
low complexity region 331 347 N/A INTRINSIC
low complexity region 349 411 N/A INTRINSIC
coiled coil region 419 444 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217936
Predicted Effect probably null
Transcript: ENSMUST00000218157
AA Change: E187*
Predicted Effect probably null
Transcript: ENSMUST00000218227
AA Change: E6*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218698
Predicted Effect probably null
Transcript: ENSMUST00000219133
AA Change: E187*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219329
Predicted Effect probably null
Transcript: ENSMUST00000219850
AA Change: E187*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219944
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220076
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit embryonic lethality after blastocyst implantation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl T C 1: 66,836,969 I398V probably benign Het
Adcy4 A T 14: 55,773,556 C635S probably benign Het
Asic4 C A 1: 75,451,323 D164E possibly damaging Het
C8g T A 2: 25,498,811 *203L probably null Het
Cad T C 5: 31,054,986 V11A probably benign Het
Cckar T C 5: 53,702,905 N194S probably damaging Het
Cdc123 T C 2: 5,798,355 probably benign Het
Chrm5 T C 2: 112,480,361 T137A probably damaging Het
Cyp1a1 A G 9: 57,702,441 probably benign Het
Dmtf1 T C 5: 9,140,474 E80G probably damaging Het
Dusp19 T A 2: 80,630,935 N189K probably damaging Het
Gfral A G 9: 76,197,238 V164A possibly damaging Het
Hk1 A T 10: 62,271,799 V799E probably damaging Het
Iars2 C T 1: 185,322,816 probably null Het
Jcad T A 18: 4,675,153 Y972N probably benign Het
Lrp1 A T 10: 127,589,636 D708E probably damaging Het
Mbtd1 T A 11: 93,924,490 H301Q probably benign Het
Med12 A G X: 101,295,855 T2004A probably benign Het
Mib1 T C 18: 10,798,356 I739T possibly damaging Het
Mthfsd C T 8: 121,108,279 probably benign Het
Mybpc3 T G 2: 91,123,889 F369C probably damaging Het
Nfatc2 C T 2: 168,534,984 V329M probably damaging Het
Ngef A T 1: 87,509,392 probably null Het
Nlrp1b T C 11: 71,168,859 E759G probably benign Het
Olfr432 C A 1: 174,050,625 T84N probably benign Het
Prdm4 T C 10: 85,893,152 E790G probably benign Het
Psmd12 A G 11: 107,485,781 D81G probably benign Het
Rnf144b A G 13: 47,242,883 H232R probably damaging Het
Sec63 C T 10: 42,810,909 T475M possibly damaging Het
Slc16a4 A T 3: 107,300,786 N204I probably benign Het
Socs1 T C 16: 10,784,540 N111S probably damaging Het
Srpr A G 9: 35,214,721 N432D probably damaging Het
Srrm2 A G 17: 23,815,734 probably benign Het
Svs1 A G 6: 48,987,118 H20R probably benign Het
Tgoln1 A G 6: 72,616,072 S142P possibly damaging Het
Trbv13-1 A G 6: 41,116,235 N34S probably benign Het
Vmn2r26 T C 6: 124,039,795 V406A possibly damaging Het
Vsig1 G T X: 140,926,339 G79V probably damaging Het
Other mutations in Dapk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Dapk3 APN 10 81184076 critical splice donor site probably null
IGL02076:Dapk3 APN 10 81190297 missense probably damaging 1.00
IGL02329:Dapk3 APN 10 81190165 missense probably benign 0.42
IGL02515:Dapk3 APN 10 81189929 splice site probably benign
R0131:Dapk3 UTSW 10 81192307 missense probably benign 0.05
R0727:Dapk3 UTSW 10 81190262 missense probably damaging 1.00
R1628:Dapk3 UTSW 10 81191809 missense possibly damaging 0.79
R5084:Dapk3 UTSW 10 81190318 intron probably null
R5222:Dapk3 UTSW 10 81192460 missense probably damaging 0.98
R6112:Dapk3 UTSW 10 81184030 missense probably benign 0.43
R6799:Dapk3 UTSW 10 81190262 missense probably damaging 1.00
R6884:Dapk3 UTSW 10 81191754 splice site probably null
Z1177:Dapk3 UTSW 10 81191769 frame shift probably null
Posted On2016-08-02