Incidental Mutation 'IGL03002:Cdc123'
ID 407408
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc123
Ensembl Gene ENSMUSG00000039128
Gene Name cell division cycle 123
Synonyms G431001I09Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock # IGL03002
Quality Score
Status
Chromosome 2
Chromosomal Location 5794294-5845164 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 5798355 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000043033 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043864]
AlphaFold Q8CII2
Predicted Effect probably benign
Transcript: ENSMUST00000043864
SMART Domains Protein: ENSMUSP00000043033
Gene: ENSMUSG00000039128

DomainStartEndE-ValueType
Pfam:D123 14 314 3e-107 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124662
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130142
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl T C 1: 66,836,969 I398V probably benign Het
Adcy4 A T 14: 55,773,556 C635S probably benign Het
Asic4 C A 1: 75,451,323 D164E possibly damaging Het
C8g T A 2: 25,498,811 *203L probably null Het
Cad T C 5: 31,054,986 V11A probably benign Het
Cckar T C 5: 53,702,905 N194S probably damaging Het
Chrm5 T C 2: 112,480,361 T137A probably damaging Het
Cyp1a1 A G 9: 57,702,441 probably benign Het
Dapk3 G T 10: 81,190,603 E187* probably null Het
Dmtf1 T C 5: 9,140,474 E80G probably damaging Het
Dusp19 T A 2: 80,630,935 N189K probably damaging Het
Gfral A G 9: 76,197,238 V164A possibly damaging Het
Hk1 A T 10: 62,271,799 V799E probably damaging Het
Iars2 C T 1: 185,322,816 probably null Het
Jcad T A 18: 4,675,153 Y972N probably benign Het
Lrp1 A T 10: 127,589,636 D708E probably damaging Het
Mbtd1 T A 11: 93,924,490 H301Q probably benign Het
Med12 A G X: 101,295,855 T2004A probably benign Het
Mib1 T C 18: 10,798,356 I739T possibly damaging Het
Mthfsd C T 8: 121,108,279 probably benign Het
Mybpc3 T G 2: 91,123,889 F369C probably damaging Het
Nfatc2 C T 2: 168,534,984 V329M probably damaging Het
Ngef A T 1: 87,509,392 probably null Het
Nlrp1b T C 11: 71,168,859 E759G probably benign Het
Olfr432 C A 1: 174,050,625 T84N probably benign Het
Prdm4 T C 10: 85,893,152 E790G probably benign Het
Psmd12 A G 11: 107,485,781 D81G probably benign Het
Rnf144b A G 13: 47,242,883 H232R probably damaging Het
Sec63 C T 10: 42,810,909 T475M possibly damaging Het
Slc16a4 A T 3: 107,300,786 N204I probably benign Het
Socs1 T C 16: 10,784,540 N111S probably damaging Het
Srpr A G 9: 35,214,721 N432D probably damaging Het
Srrm2 A G 17: 23,815,734 probably benign Het
Svs1 A G 6: 48,987,118 H20R probably benign Het
Tgoln1 A G 6: 72,616,072 S142P possibly damaging Het
Trbv13-1 A G 6: 41,116,235 N34S probably benign Het
Vmn2r26 T C 6: 124,039,795 V406A possibly damaging Het
Vsig1 G T X: 140,926,339 G79V probably damaging Het
Other mutations in Cdc123
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Cdc123 APN 2 5804935 missense probably benign 0.01
IGL00422:Cdc123 APN 2 5798449 missense probably benign 0.07
IGL01860:Cdc123 APN 2 5803941 splice site probably benign
Sinking UTSW 2 5798363 missense possibly damaging 0.82
R0563:Cdc123 UTSW 2 5798401 missense probably benign
R1412:Cdc123 UTSW 2 5803965 missense possibly damaging 0.80
R1584:Cdc123 UTSW 2 5803977 critical splice acceptor site probably null
R1838:Cdc123 UTSW 2 5794891 splice site probably null
R2064:Cdc123 UTSW 2 5795543 splice site probably benign
R2144:Cdc123 UTSW 2 5810806 missense probably benign 0.19
R4082:Cdc123 UTSW 2 5810755 intron probably benign
R4679:Cdc123 UTSW 2 5844892 missense probably damaging 1.00
R4970:Cdc123 UTSW 2 5804937 missense possibly damaging 0.59
R5089:Cdc123 UTSW 2 5805000 missense probably benign 0.00
R5112:Cdc123 UTSW 2 5804937 missense possibly damaging 0.59
R5691:Cdc123 UTSW 2 5823175 missense probably benign 0.00
R5914:Cdc123 UTSW 2 5798363 missense possibly damaging 0.82
R7860:Cdc123 UTSW 2 5803964 missense probably benign 0.00
R8695:Cdc123 UTSW 2 5821363 missense possibly damaging 0.69
R8865:Cdc123 UTSW 2 5795424 intron probably benign
R9018:Cdc123 UTSW 2 5844872 missense probably benign 0.00
R9265:Cdc123 UTSW 2 5803954 missense possibly damaging 0.50
Z1176:Cdc123 UTSW 2 5804985 missense probably damaging 0.97
Posted On 2016-08-02