Incidental Mutation 'IGL03003:Aff3'
| ID |
407454 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Aff3
|
| Ensembl Gene |
ENSMUSG00000037138 |
| Gene Name |
AF4/FMR2 family, member 3 |
| Synonyms |
LAF-4, 3222402O04Rik, Laf4 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03003
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
38216407-38704036 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 38248651 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 819
(S819T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092637
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039827]
[ENSMUST00000095027]
|
| AlphaFold |
P51827 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000039827
AA Change: S818T
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000044128
Gene: ENSMUSG00000037138
AA Change: S818T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:AF-4
|
20 |
170 |
4.9e-63 |
PFAM |
|
Pfam:AF-4
|
160 |
1226 |
N/A |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000095027
AA Change: S819T
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000092637
Gene: ENSMUSG00000037138
AA Change: S819T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:AF-4
|
20 |
172 |
1.7e-47 |
PFAM |
|
Pfam:AF-4
|
161 |
1226 |
3.8e-268 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AA986860 |
C |
T |
1: 130,671,509 (GRCm39) |
P577L |
probably damaging |
Het |
| Aftph |
G |
T |
11: 20,676,982 (GRCm39) |
S209* |
probably null |
Het |
| Astn1 |
T |
A |
1: 158,439,965 (GRCm39) |
D844E |
probably benign |
Het |
| Cc2d2a |
A |
G |
5: 43,828,608 (GRCm39) |
K29E |
probably benign |
Het |
| Ccdc93 |
T |
C |
1: 121,390,846 (GRCm39) |
S273P |
possibly damaging |
Het |
| Cd200r3 |
C |
A |
16: 44,764,139 (GRCm39) |
H2N |
probably benign |
Het |
| Cd200r3 |
G |
T |
16: 44,764,138 (GRCm39) |
M1I |
probably null |
Het |
| Col7a1 |
G |
A |
9: 108,804,024 (GRCm39) |
|
probably null |
Het |
| Cyp3a41a |
T |
A |
5: 145,642,640 (GRCm39) |
M240L |
probably benign |
Het |
| Dcstamp |
T |
C |
15: 39,617,906 (GRCm39) |
V105A |
possibly damaging |
Het |
| Dmbt1 |
C |
A |
7: 130,684,409 (GRCm39) |
P635Q |
probably benign |
Het |
| Dsg1a |
T |
A |
18: 20,469,876 (GRCm39) |
M634K |
probably benign |
Het |
| Farp2 |
T |
C |
1: 93,495,140 (GRCm39) |
Y138H |
probably damaging |
Het |
| Fga |
T |
C |
3: 82,940,037 (GRCm39) |
S564P |
probably damaging |
Het |
| Gbf1 |
T |
C |
19: 46,244,094 (GRCm39) |
L142S |
probably damaging |
Het |
| Gm5422 |
T |
C |
10: 31,126,840 (GRCm39) |
|
noncoding transcript |
Het |
| Helz2 |
A |
G |
2: 180,882,046 (GRCm39) |
V249A |
probably damaging |
Het |
| Hmcn2 |
C |
A |
2: 31,323,498 (GRCm39) |
T4204K |
probably damaging |
Het |
| Ift81 |
T |
C |
5: 122,732,725 (GRCm39) |
I270V |
probably benign |
Het |
| Katnip |
A |
T |
7: 125,451,132 (GRCm39) |
I1088F |
probably damaging |
Het |
| Kif6 |
C |
T |
17: 50,060,899 (GRCm39) |
R411* |
probably null |
Het |
| Klhl35 |
T |
A |
7: 99,119,550 (GRCm39) |
V345D |
probably damaging |
Het |
| Mcm3ap |
C |
A |
10: 76,340,531 (GRCm39) |
D1531E |
probably benign |
Het |
| Muc5b |
C |
A |
7: 141,417,351 (GRCm39) |
D3432E |
probably benign |
Het |
| Nipbl |
A |
T |
15: 8,379,798 (GRCm39) |
V998D |
probably damaging |
Het |
| Nlrc3 |
C |
A |
16: 3,782,726 (GRCm39) |
V228L |
probably benign |
Het |
| Nrap |
T |
C |
19: 56,310,384 (GRCm39) |
H1456R |
probably damaging |
Het |
| Nt5c1b |
C |
T |
12: 10,424,910 (GRCm39) |
A210V |
possibly damaging |
Het |
| Or13a18 |
A |
G |
7: 140,190,283 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or1l4b |
T |
C |
2: 37,036,464 (GRCm39) |
V80A |
probably benign |
Het |
| Osbpl7 |
T |
C |
11: 96,941,521 (GRCm39) |
Y15H |
probably benign |
Het |
| Pde8b |
T |
A |
13: 95,178,465 (GRCm39) |
N552Y |
probably damaging |
Het |
| Pi4kb |
T |
A |
3: 94,892,123 (GRCm39) |
S280T |
probably benign |
Het |
| Pkd1 |
T |
A |
17: 24,812,577 (GRCm39) |
|
probably null |
Het |
| Polh |
A |
T |
17: 46,505,292 (GRCm39) |
V108E |
possibly damaging |
Het |
| Prob1 |
A |
G |
18: 35,786,428 (GRCm39) |
S609P |
possibly damaging |
Het |
| Ptprz1 |
T |
A |
6: 23,002,582 (GRCm39) |
N1557K |
probably damaging |
Het |
| Rev1 |
A |
C |
1: 38,127,154 (GRCm39) |
F369V |
possibly damaging |
Het |
| Rgma |
A |
G |
7: 73,067,188 (GRCm39) |
N148D |
probably damaging |
Het |
| Robo3 |
A |
G |
9: 37,330,587 (GRCm39) |
L1003S |
probably damaging |
Het |
| Sdhb |
T |
C |
4: 140,700,311 (GRCm39) |
V137A |
probably damaging |
Het |
| Sema6c |
T |
C |
3: 95,076,925 (GRCm39) |
L337P |
probably damaging |
Het |
| Shc4 |
A |
T |
2: 125,565,253 (GRCm39) |
Y15* |
probably null |
Het |
| Slc4a9 |
T |
C |
18: 36,669,946 (GRCm39) |
S722P |
probably damaging |
Het |
| Smarcc1 |
A |
G |
9: 110,035,168 (GRCm39) |
N864D |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,432,021 (GRCm39) |
L745P |
probably damaging |
Het |
| Syce1l |
A |
G |
8: 114,380,699 (GRCm39) |
D137G |
probably damaging |
Het |
| Tbc1d1 |
G |
T |
5: 64,473,781 (GRCm39) |
W768L |
probably damaging |
Het |
| Tmbim7 |
A |
G |
5: 3,711,887 (GRCm39) |
D7G |
probably benign |
Het |
| Tmem109 |
A |
C |
19: 10,851,695 (GRCm39) |
S64A |
probably benign |
Het |
| Tnfrsf21 |
A |
G |
17: 43,350,834 (GRCm39) |
R333G |
probably damaging |
Het |
| Ttn |
T |
G |
2: 76,611,955 (GRCm39) |
S17316R |
probably damaging |
Het |
| Usp10 |
A |
G |
8: 120,681,549 (GRCm39) |
T668A |
possibly damaging |
Het |
| Xirp2 |
T |
A |
2: 67,345,906 (GRCm39) |
F2716I |
possibly damaging |
Het |
|
| Other mutations in Aff3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01364:Aff3
|
APN |
1 |
38,574,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02263:Aff3
|
APN |
1 |
38,574,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02962:Aff3
|
APN |
1 |
38,574,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03180:Aff3
|
APN |
1 |
38,574,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03389:Aff3
|
APN |
1 |
38,249,430 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
PIT4377001:Aff3
|
UTSW |
1 |
38,578,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4544001:Aff3
|
UTSW |
1 |
38,249,443 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0004:Aff3
|
UTSW |
1 |
38,308,807 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0004:Aff3
|
UTSW |
1 |
38,308,807 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0026:Aff3
|
UTSW |
1 |
38,242,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0279:Aff3
|
UTSW |
1 |
38,574,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0344:Aff3
|
UTSW |
1 |
38,243,013 (GRCm39) |
missense |
probably benign |
|
|
R0375:Aff3
|
UTSW |
1 |
38,244,021 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0605:Aff3
|
UTSW |
1 |
38,249,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0613:Aff3
|
UTSW |
1 |
38,249,004 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0742:Aff3
|
UTSW |
1 |
38,666,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1156:Aff3
|
UTSW |
1 |
38,243,991 (GRCm39) |
missense |
probably benign |
|
|
R1255:Aff3
|
UTSW |
1 |
38,243,965 (GRCm39) |
splice site |
probably null |
|
|
R1448:Aff3
|
UTSW |
1 |
38,230,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1760:Aff3
|
UTSW |
1 |
38,368,945 (GRCm39) |
splice site |
probably benign |
|
|
R1780:Aff3
|
UTSW |
1 |
38,574,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Aff3
|
UTSW |
1 |
38,249,385 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2011:Aff3
|
UTSW |
1 |
38,246,996 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2331:Aff3
|
UTSW |
1 |
38,243,971 (GRCm39) |
splice site |
probably null |
|
|
R2965:Aff3
|
UTSW |
1 |
38,248,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2970:Aff3
|
UTSW |
1 |
38,574,103 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3015:Aff3
|
UTSW |
1 |
38,249,649 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3763:Aff3
|
UTSW |
1 |
38,291,770 (GRCm39) |
splice site |
probably benign |
|
|
R4174:Aff3
|
UTSW |
1 |
38,247,008 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4436:Aff3
|
UTSW |
1 |
38,248,768 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4661:Aff3
|
UTSW |
1 |
38,666,209 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5069:Aff3
|
UTSW |
1 |
38,220,694 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Aff3
|
UTSW |
1 |
38,220,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Aff3
|
UTSW |
1 |
38,257,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6209:Aff3
|
UTSW |
1 |
38,232,670 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6467:Aff3
|
UTSW |
1 |
38,247,098 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6748:Aff3
|
UTSW |
1 |
38,574,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6862:Aff3
|
UTSW |
1 |
38,445,578 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6880:Aff3
|
UTSW |
1 |
38,666,209 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6880:Aff3
|
UTSW |
1 |
38,574,243 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7187:Aff3
|
UTSW |
1 |
38,257,478 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8322:Aff3
|
UTSW |
1 |
38,220,742 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8329:Aff3
|
UTSW |
1 |
38,244,135 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8737:Aff3
|
UTSW |
1 |
38,308,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9093:Aff3
|
UTSW |
1 |
38,291,738 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9146:Aff3
|
UTSW |
1 |
38,359,200 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9149:Aff3
|
UTSW |
1 |
38,220,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9157:Aff3
|
UTSW |
1 |
38,249,559 (GRCm39) |
missense |
probably benign |
0.45 |
|
R9446:Aff3
|
UTSW |
1 |
38,574,337 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9581:Aff3
|
UTSW |
1 |
38,249,266 (GRCm39) |
missense |
probably benign |
|
|
R9645:Aff3
|
UTSW |
1 |
38,249,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9674:Aff3
|
UTSW |
1 |
38,248,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Aff3
|
UTSW |
1 |
38,368,953 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation