Incidental Mutation 'IGL03003:Kif6'
ID 407461
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif6
Ensembl Gene ENSMUSG00000023999
Gene Name kinesin family member 6
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.132) question?
Stock # IGL03003
Quality Score
Status
Chromosome 17
Chromosomal Location 49615136-49909847 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 49753871 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 411 (R411*)
Ref Sequence ENSEMBL: ENSMUSP00000124674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162854]
AlphaFold E9PX57
Predicted Effect noncoding transcript
Transcript: ENSMUST00000024798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159396
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160049
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162419
Predicted Effect probably null
Transcript: ENSMUST00000162854
AA Change: R411*
SMART Domains Protein: ENSMUSP00000124674
Gene: ENSMUSG00000023999
AA Change: R411*

DomainStartEndE-ValueType
KISc 3 353 1.67e-121 SMART
coiled coil region 358 385 N/A INTRINSIC
Blast:KISc 400 606 1e-85 BLAST
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozgyos for an ENU-induced allele exhibit normal exercise capacity and cardiac function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 C T 1: 130,743,772 P577L probably damaging Het
Aff3 A T 1: 38,209,570 S819T probably damaging Het
Aftph G T 11: 20,726,982 S209* probably null Het
Astn1 T A 1: 158,612,395 D844E probably benign Het
Cc2d2a A G 5: 43,671,266 K29E probably benign Het
Ccdc93 T C 1: 121,463,117 S273P possibly damaging Het
Cd200r3 C A 16: 44,943,776 H2N probably benign Het
Cd200r3 G T 16: 44,943,775 M1I probably null Het
Col7a1 G A 9: 108,974,956 probably null Het
Cyp3a41a T A 5: 145,705,830 M240L probably benign Het
D430042O09Rik A T 7: 125,851,960 I1088F probably damaging Het
Dcstamp T C 15: 39,754,510 V105A possibly damaging Het
Dmbt1 C A 7: 131,082,679 P635Q probably benign Het
Dsg1a T A 18: 20,336,819 M634K probably benign Het
Farp2 T C 1: 93,567,418 Y138H probably damaging Het
Fga T C 3: 83,032,730 S564P probably damaging Het
Gbf1 T C 19: 46,255,655 L142S probably damaging Het
Gm5422 T C 10: 31,250,844 noncoding transcript Het
Helz2 A G 2: 181,240,253 V249A probably damaging Het
Hmcn2 C A 2: 31,433,486 T4204K probably damaging Het
Ift81 T C 5: 122,594,662 I270V probably benign Het
Klhl35 T A 7: 99,470,343 V345D probably damaging Het
Mcm3ap C A 10: 76,504,697 D1531E probably benign Het
Muc5b C A 7: 141,863,614 D3432E probably benign Het
Nipbl A T 15: 8,350,314 V998D probably damaging Het
Nlrc3 C A 16: 3,964,862 V228L probably benign Het
Nrap T C 19: 56,321,952 H1456R probably damaging Het
Nt5c1b C T 12: 10,374,910 A210V possibly damaging Het
Olfr364-ps1 T C 2: 37,146,452 V80A probably benign Het
Olfr46 A G 7: 140,610,370 Y60C probably damaging Het
Osbpl7 T C 11: 97,050,695 Y15H probably benign Het
Pde8b T A 13: 95,041,957 N552Y probably damaging Het
Pi4kb T A 3: 94,984,812 S280T probably benign Het
Pkd1 T A 17: 24,593,603 probably null Het
Polh A T 17: 46,194,366 V108E possibly damaging Het
Prob1 A G 18: 35,653,375 S609P possibly damaging Het
Ptprz1 T A 6: 23,002,583 N1557K probably damaging Het
Rev1 A C 1: 38,088,073 F369V possibly damaging Het
Rgma A G 7: 73,417,440 N148D probably damaging Het
Robo3 A G 9: 37,419,291 L1003S probably damaging Het
Sdhb T C 4: 140,973,000 V137A probably damaging Het
Sema6c T C 3: 95,169,614 L337P probably damaging Het
Shc4 A T 2: 125,723,333 Y15* probably null Het
Slc4a9 T C 18: 36,536,893 S722P probably damaging Het
Smarcc1 A G 9: 110,206,100 N864D probably damaging Het
Sspo T C 6: 48,455,087 L745P probably damaging Het
Syce1l A G 8: 113,654,067 D137G probably damaging Het
Tbc1d1 G T 5: 64,316,438 W768L probably damaging Het
Tmbim7 A G 5: 3,661,887 D7G probably benign Het
Tmem109 A C 19: 10,874,331 S64A probably benign Het
Tnfrsf21 A G 17: 43,039,943 R333G probably damaging Het
Ttn T G 2: 76,781,611 S17316R probably damaging Het
Usp10 A G 8: 119,954,810 T668A possibly damaging Het
Xirp2 T A 2: 67,515,562 F2716I possibly damaging Het
Other mutations in Kif6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01793:Kif6 APN 17 49624493 missense probably damaging 0.99
IGL02098:Kif6 APN 17 49870894 missense probably benign 0.36
IGL02259:Kif6 APN 17 49895891 splice site probably benign
PIT4280001:Kif6 UTSW 17 49755120 missense probably benign 0.32
R0044:Kif6 UTSW 17 49832256 splice site probably benign
R1180:Kif6 UTSW 17 49832256 splice site probably benign
R1432:Kif6 UTSW 17 49620700 missense probably damaging 1.00
R1522:Kif6 UTSW 17 49714113 missense probably damaging 0.99
R1760:Kif6 UTSW 17 49615283 missense probably benign 0.00
R1770:Kif6 UTSW 17 49903649 missense possibly damaging 0.92
R1809:Kif6 UTSW 17 49901784 missense probably benign 0.00
R1854:Kif6 UTSW 17 49901771 missense probably benign 0.25
R2176:Kif6 UTSW 17 49755230 missense probably damaging 1.00
R3766:Kif6 UTSW 17 49758643 splice site probably benign
R4620:Kif6 UTSW 17 49901296 missense probably benign
R4661:Kif6 UTSW 17 49753881 missense probably benign 0.21
R4972:Kif6 UTSW 17 49707619 missense probably damaging 1.00
R5735:Kif6 UTSW 17 49832182 missense probably damaging 1.00
R5950:Kif6 UTSW 17 49715088 missense probably damaging 0.99
R6364:Kif6 UTSW 17 49620623 missense probably benign 0.01
R7604:Kif6 UTSW 17 49671101 missense probably damaging 1.00
R7879:Kif6 UTSW 17 49832186 missense probably benign 0.08
R7966:Kif6 UTSW 17 49686425 missense probably damaging 0.98
R8246:Kif6 UTSW 17 49758514 nonsense probably null
R8487:Kif6 UTSW 17 49671136 missense probably damaging 1.00
X0067:Kif6 UTSW 17 49832167 missense probably benign 0.01
Z1177:Kif6 UTSW 17 49715100 missense probably damaging 1.00
Posted On 2016-08-02