Incidental Mutation 'IGL03005:Lipo3'
ID 407504
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lipo3
Ensembl Gene ENSMUSG00000024766
Gene Name lipase, member O3
Synonyms Lipo1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL03005
Quality Score
Status
Chromosome 19
Chromosomal Location 33532560-33568069 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 33763136 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 36 (I36V)
Ref Sequence ENSEMBL: ENSMUSP00000136249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178735]
AlphaFold Q3UT41
Predicted Effect unknown
Transcript: ENSMUST00000148137
AA Change: I39V
SMART Domains Protein: ENSMUSP00000118385
Gene: ENSMUSG00000079342
AA Change: I39V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Abhydro_lipase 37 99 2.8e-21 PFAM
Pfam:Hydrolase_4 76 239 4.3e-8 PFAM
Pfam:Abhydrolase_1 80 219 2.2e-17 PFAM
Pfam:Abhydrolase_5 80 233 8.7e-8 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000178735
AA Change: I36V

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000136249
Gene: ENSMUSG00000079342
AA Change: I36V

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 1.3e-20 PFAM
Pfam:Hydrolase_4 72 231 3.5e-8 PFAM
Pfam:Abhydrolase_5 76 370 3.7e-10 PFAM
Pfam:Abhydrolase_1 76 376 6.8e-21 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt3 A T 1: 176,894,793 (GRCm39) V268E probably damaging Het
Aoc1l1 T A 6: 48,953,480 (GRCm39) Y468* probably null Het
Apob A G 12: 8,043,059 (GRCm39) probably benign Het
Arhgap19 T C 19: 41,772,856 (GRCm39) probably benign Het
C2cd2 A G 16: 97,660,632 (GRCm39) L672P probably damaging Het
Cars1 A G 7: 143,112,906 (GRCm39) F774L probably damaging Het
Cd200r3 T A 16: 44,773,973 (GRCm39) S128R probably damaging Het
Chd9 A G 8: 91,738,075 (GRCm39) N1569S probably damaging Het
Chmp7 G A 14: 69,957,277 (GRCm39) R294C probably damaging Het
Col10a1 A T 10: 34,271,734 (GRCm39) I569F probably damaging Het
Cspg4 T A 9: 56,795,772 (GRCm39) V1169D probably damaging Het
Emg1 G A 6: 124,681,557 (GRCm39) T229I probably damaging Het
Fmo9 C T 1: 166,502,088 (GRCm39) S179N probably benign Het
Frem1 T C 4: 82,912,371 (GRCm39) Y667C probably damaging Het
Gpsm2 A G 3: 108,594,322 (GRCm39) probably benign Het
Gsdma A T 11: 98,567,085 (GRCm39) E395V probably damaging Het
Gsdmd C T 15: 75,739,015 (GRCm39) T464M possibly damaging Het
Iqschfp C A 3: 68,526,010 (GRCm39) Q395K possibly damaging Het
Lrrtm1 A G 6: 77,221,139 (GRCm39) S199G probably damaging Het
Lypla1 C T 1: 4,902,613 (GRCm39) probably benign Het
Mst1r C T 9: 107,791,748 (GRCm39) Q809* probably null Het
Mtr T A 13: 12,250,335 (GRCm39) probably benign Het
Or4a39 G A 2: 89,237,315 (GRCm39) T36I possibly damaging Het
Pax7 T A 4: 139,556,007 (GRCm39) I156F probably damaging Het
Pcdhb8 T A 18: 37,490,587 (GRCm39) L755Q probably damaging Het
Pdzd2 G A 15: 12,385,351 (GRCm39) P1140S probably damaging Het
Pdzrn4 T C 15: 92,668,272 (GRCm39) L808P probably damaging Het
Pex1 G T 5: 3,680,292 (GRCm39) Q971H probably null Het
Pgap6 C T 17: 26,337,911 (GRCm39) L432F probably benign Het
Pld1 T A 3: 28,141,402 (GRCm39) V655E possibly damaging Het
Pnpla3 C T 15: 84,058,469 (GRCm39) R163W probably damaging Het
Rabgef1 T C 5: 130,237,638 (GRCm39) L237P probably damaging Het
Setbp1 A T 18: 78,902,340 (GRCm39) N442K possibly damaging Het
Sorl1 T G 9: 41,968,621 (GRCm39) D544A probably damaging Het
Spire2 C A 8: 124,090,107 (GRCm39) P490T probably benign Het
Zeb1 T A 18: 5,767,150 (GRCm39) S554T probably benign Het
Other mutations in Lipo3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01521:Lipo3 APN 19 33,763,083 (GRCm39) missense probably damaging 1.00
IGL01697:Lipo3 APN 19 33,536,965 (GRCm39) missense probably damaging 1.00
IGL01916:Lipo3 APN 19 33,762,182 (GRCm39) missense probably damaging 1.00
IGL02027:Lipo3 APN 19 33,557,919 (GRCm39) nonsense probably null
IGL02047:Lipo3 APN 19 33,534,562 (GRCm39) missense probably benign 0.00
IGL02586:Lipo3 APN 19 33,559,539 (GRCm39) missense possibly damaging 0.95
IGL03111:Lipo3 APN 19 33,559,637 (GRCm39) missense probably damaging 0.96
IGL03404:Lipo3 APN 19 33,560,440 (GRCm39) splice site probably benign
R0122:Lipo3 UTSW 19 33,600,086 (GRCm39) intron probably benign
R0128:Lipo3 UTSW 19 33,534,506 (GRCm39) critical splice donor site probably null
R0540:Lipo3 UTSW 19 33,536,967 (GRCm39) missense possibly damaging 0.62
R0551:Lipo3 UTSW 19 33,557,951 (GRCm39) missense probably damaging 1.00
R0568:Lipo3 UTSW 19 33,559,442 (GRCm39) splice site probably benign
R0646:Lipo3 UTSW 19 33,762,169 (GRCm39) nonsense probably null
R0669:Lipo3 UTSW 19 33,537,025 (GRCm39) missense probably benign 0.05
R1704:Lipo3 UTSW 19 33,757,743 (GRCm39) missense possibly damaging 0.87
R1772:Lipo3 UTSW 19 33,764,821 (GRCm39) missense probably benign 0.45
R1862:Lipo3 UTSW 19 33,762,092 (GRCm39) missense probably damaging 1.00
R1863:Lipo3 UTSW 19 33,762,092 (GRCm39) missense probably damaging 1.00
R2911:Lipo3 UTSW 19 33,556,767 (GRCm39) missense probably benign 0.00
R3801:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3802:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3803:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3973:Lipo3 UTSW 19 33,535,723 (GRCm39) missense probably damaging 1.00
R4020:Lipo3 UTSW 19 33,764,804 (GRCm39) missense probably benign 0.00
R4648:Lipo3 UTSW 19 33,760,860 (GRCm39) missense probably damaging 1.00
R4660:Lipo3 UTSW 19 33,598,360 (GRCm39) intron probably benign
R4775:Lipo3 UTSW 19 33,757,795 (GRCm39) missense probably damaging 1.00
R4787:Lipo3 UTSW 19 33,757,749 (GRCm39) missense probably benign 0.00
R4820:Lipo3 UTSW 19 33,560,497 (GRCm39) missense probably damaging 1.00
R4830:Lipo3 UTSW 19 33,753,987 (GRCm39) missense probably damaging 0.99
R4951:Lipo3 UTSW 19 33,759,621 (GRCm39) missense probably benign 0.01
R5117:Lipo3 UTSW 19 33,536,952 (GRCm39) missense probably benign
R5258:Lipo3 UTSW 19 33,591,243 (GRCm39) intron probably benign
R5799:Lipo3 UTSW 19 33,755,093 (GRCm39) intron probably benign
R5853:Lipo3 UTSW 19 33,759,630 (GRCm39) missense probably benign 0.37
R6235:Lipo3 UTSW 19 33,760,963 (GRCm39) missense probably damaging 0.96
R6296:Lipo3 UTSW 19 33,757,737 (GRCm39) missense probably benign 0.10
R6383:Lipo3 UTSW 19 33,533,831 (GRCm39) missense probably benign 0.02
R6659:Lipo3 UTSW 19 33,533,828 (GRCm39) missense possibly damaging 0.55
R6913:Lipo3 UTSW 19 33,757,705 (GRCm39) missense probably benign 0.00
R6915:Lipo3 UTSW 19 33,562,293 (GRCm39) missense probably damaging 1.00
R7092:Lipo3 UTSW 19 33,591,092 (GRCm39) splice site probably null
R7444:Lipo3 UTSW 19 33,535,663 (GRCm39) critical splice donor site probably null
R7532:Lipo3 UTSW 19 33,560,464 (GRCm39) missense possibly damaging 0.90
R7672:Lipo3 UTSW 19 33,757,785 (GRCm39) missense probably benign 0.23
R7796:Lipo3 UTSW 19 33,759,634 (GRCm39) missense possibly damaging 0.75
R7945:Lipo3 UTSW 19 33,533,831 (GRCm39) missense probably benign 0.02
R8683:Lipo3 UTSW 19 33,759,604 (GRCm39) missense probably benign 0.04
R8936:Lipo3 UTSW 19 33,557,880 (GRCm39) missense probably damaging 1.00
R9062:Lipo3 UTSW 19 33,757,714 (GRCm39) missense probably damaging 1.00
R9086:Lipo3 UTSW 19 33,534,529 (GRCm39) missense probably benign 0.44
R9432:Lipo3 UTSW 19 33,533,864 (GRCm39) missense probably damaging 1.00
R9615:Lipo3 UTSW 19 33,754,047 (GRCm39) missense probably benign 0.02
R9620:Lipo3 UTSW 19 33,559,629 (GRCm39) nonsense probably null
Z1176:Lipo3 UTSW 19 33,562,328 (GRCm39) missense probably null 0.97
Posted On 2016-08-02