Incidental Mutation 'IGL03007:Olfr963'
ID407606
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr963
Ensembl Gene ENSMUSG00000064110
Gene Nameolfactory receptor 963
SynonymsMOR224-13, MOR224-7P, GA_x6K02T2PVTD-33365879-33366814
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #IGL03007
Quality Score
Status
Chromosome9
Chromosomal Location39667205-39670783 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 39669471 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 138 (V138A)
Ref Sequence ENSEMBL: ENSMUSP00000148985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073433] [ENSMUST00000215649]
Predicted Effect possibly damaging
Transcript: ENSMUST00000073433
AA Change: V138A

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000073139
Gene: ENSMUSG00000064110
AA Change: V138A

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-49 PFAM
Pfam:7tm_1 39 286 2.4e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215649
AA Change: V138A

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,222,038 N144D possibly damaging Het
A830010M20Rik T A 5: 107,503,676 V145E probably benign Het
A830031A19Rik T C 11: 24,049,248 probably benign Het
Ankfy1 T C 11: 72,750,521 F640S probably damaging Het
Asb8 A G 15: 98,142,734 Y16H probably damaging Het
Astn1 T C 1: 158,668,623 probably benign Het
Celf3 A G 3: 94,487,137 T183A probably benign Het
Dctn1 T C 6: 83,182,708 V56A probably damaging Het
Erbb2 A C 11: 98,428,993 probably benign Het
Ighv6-4 A T 12: 114,406,593 Y80N possibly damaging Het
Igsf9b T C 9: 27,333,082 S782P probably damaging Het
Itsn1 A T 16: 91,784,162 probably benign Het
Kcnt2 T A 1: 140,354,507 Y77N possibly damaging Het
Lig3 T C 11: 82,789,575 F359S probably damaging Het
Mtmr6 G T 14: 60,289,535 probably benign Het
Muc4 C T 16: 32,752,048 S642F possibly damaging Het
Ncoa1 T A 12: 4,339,114 I54F possibly damaging Het
Nfx1 C A 4: 40,984,962 T362K probably benign Het
Ntrk1 T C 3: 87,782,743 S449G possibly damaging Het
Odc1 T A 12: 17,548,810 H230Q probably benign Het
Olfr26 C T 9: 38,855,296 T78I probably damaging Het
Olfr348 T C 2: 36,786,800 S92P probably damaging Het
Olfr63 A G 17: 33,268,883 E53G probably damaging Het
Plekhh2 A C 17: 84,574,960 S665R possibly damaging Het
Qpct T A 17: 79,070,865 F155I probably damaging Het
Rcor2 C A 19: 7,274,353 T379K probably benign Het
Rint1 A G 5: 23,815,701 N574S probably benign Het
Rsbn1 C T 3: 103,928,879 A411V probably damaging Het
Sbno2 A T 10: 80,058,550 probably benign Het
Sptb A G 12: 76,621,341 S661P probably damaging Het
Syn3 A T 10: 86,064,914 M370K possibly damaging Het
Tex101 G A 7: 24,670,481 probably benign Het
Tmem255b C T 8: 13,457,066 T265I possibly damaging Het
Trio G T 15: 27,902,742 A211D probably damaging Het
Zfp638 C A 6: 83,984,884 Q1902K probably damaging Het
Other mutations in Olfr963
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02043:Olfr963 APN 9 39669078 missense probably damaging 1.00
R1177:Olfr963 UTSW 9 39669641 missense probably benign 0.04
R1378:Olfr963 UTSW 9 39669666 missense probably damaging 1.00
R1517:Olfr963 UTSW 9 39669720 missense probably damaging 0.99
R2016:Olfr963 UTSW 9 39669555 missense probably damaging 1.00
R2212:Olfr963 UTSW 9 39669228 missense probably damaging 1.00
R2393:Olfr963 UTSW 9 39669273 missense possibly damaging 0.53
R5464:Olfr963 UTSW 9 39669770 missense probably damaging 1.00
R5886:Olfr963 UTSW 9 39669956 missense probably benign 0.01
R5935:Olfr963 UTSW 9 39669090 missense probably benign
R7756:Olfr963 UTSW 9 39669075 missense probably benign
R7758:Olfr963 UTSW 9 39669075 missense probably benign
R7775:Olfr963 UTSW 9 39669238 missense possibly damaging 0.65
R7778:Olfr963 UTSW 9 39669238 missense possibly damaging 0.65
Posted On2016-08-02