Incidental Mutation 'IGL03008:Slc22a27'
ID 407672
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc22a27
Ensembl Gene ENSMUSG00000067656
Gene Name solute carrier family 22, member 27
Synonyms AB056442, mOAT6 related protein
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL03008
Quality Score
Status
Chromosome 19
Chromosomal Location 7841753-7943392 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7887067 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 274 (I274T)
Ref Sequence ENSEMBL: ENSMUSP00000093991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075619] [ENSMUST00000182102]
AlphaFold Q76M72
Predicted Effect possibly damaging
Transcript: ENSMUST00000075619
AA Change: I274T

PolyPhen 2 Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000093991
Gene: ENSMUSG00000067656
AA Change: I274T

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 99 528 1.5e-25 PFAM
Pfam:MFS_1 140 372 1.3e-15 PFAM
Pfam:MFS_1 349 549 8.3e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000182102
SMART Domains Protein: ENSMUSP00000138475
Gene: ENSMUSG00000067656

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:MFS_1 241 441 1.2e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aga T C 8: 53,964,861 (GRCm39) S8P probably benign Het
Ankrd34c C T 9: 89,612,337 (GRCm39) M1I probably null Het
Ankrd44 T C 1: 54,805,968 (GRCm39) H146R probably damaging Het
Bst1 A G 5: 43,983,604 (GRCm39) probably null Het
Btbd8 T G 5: 107,639,464 (GRCm39) probably null Het
Cdh12 A T 15: 21,480,416 (GRCm39) I211F probably damaging Het
Cenpj G T 14: 56,764,406 (GRCm39) D1335E probably benign Het
Clpx G A 9: 65,230,057 (GRCm39) V502I possibly damaging Het
Cntnap4 T C 8: 113,500,222 (GRCm39) S505P probably benign Het
Cog2 T C 8: 125,262,131 (GRCm39) probably benign Het
Cped1 A G 6: 22,233,601 (GRCm39) Q819R probably benign Het
Cspg4 A G 9: 56,805,759 (GRCm39) E2190G possibly damaging Het
Ctsa G A 2: 164,679,368 (GRCm39) R359Q probably damaging Het
Cul9 A G 17: 46,813,623 (GRCm39) probably benign Het
Dab1 G T 4: 104,584,777 (GRCm39) V306F probably damaging Het
Dysf A G 6: 84,050,876 (GRCm39) I438V probably benign Het
Eif4g3 G T 4: 137,847,699 (GRCm39) G380W probably damaging Het
Exd1 T A 2: 119,350,862 (GRCm39) K466N probably benign Het
Eya3 A C 4: 132,434,294 (GRCm39) D325A probably damaging Het
Fmn1 A G 2: 113,195,445 (GRCm39) T382A unknown Het
Fry T A 5: 150,269,021 (GRCm39) D106E possibly damaging Het
Gm21957 T A 7: 124,818,733 (GRCm39) noncoding transcript Het
Gm44511 A G 6: 128,761,059 (GRCm39) probably benign Het
Itga4 A G 2: 79,155,982 (GRCm39) I983V probably benign Het
Lrpprc A T 17: 85,058,675 (GRCm39) D5E probably benign Het
Lrrc37 T C 11: 103,511,293 (GRCm39) E225G unknown Het
Ltbp4 G T 7: 27,023,789 (GRCm39) N747K probably damaging Het
Minar1 A G 9: 89,478,731 (GRCm39) Y772H probably damaging Het
Mlh3 T C 12: 85,287,625 (GRCm39) Q1308R probably benign Het
Mtfr2 T A 10: 20,229,185 (GRCm39) C63S possibly damaging Het
Myh11 T A 16: 14,022,617 (GRCm39) M1661L probably benign Het
Myo1c T C 11: 75,549,240 (GRCm39) M137T probably benign Het
Myocd A C 11: 65,078,392 (GRCm39) L340V probably damaging Het
Napsa A T 7: 44,235,220 (GRCm39) Q335L possibly damaging Het
Nlrp4b C A 7: 10,448,516 (GRCm39) Q240K probably benign Het
Npepps A C 11: 97,128,984 (GRCm39) F400C probably damaging Het
Nxpe4 A T 9: 48,304,738 (GRCm39) E275V probably benign Het
Ofd1 T C X: 165,192,530 (GRCm39) D501G probably benign Het
Or13a19 T C 7: 139,903,445 (GRCm39) Y278H probably damaging Het
Or4f6 A G 2: 111,838,868 (GRCm39) I221T possibly damaging Het
Or5p79 T G 7: 108,221,490 (GRCm39) L157R probably damaging Het
Or8k41 A T 2: 86,313,678 (GRCm39) M136K probably damaging Het
P2ry1 A T 3: 60,910,947 (GRCm39) T29S probably benign Het
Papss1 T C 3: 131,290,860 (GRCm39) V201A possibly damaging Het
Paxip1 A G 5: 27,957,764 (GRCm39) V864A probably benign Het
Pcdhgc5 T A 18: 37,954,887 (GRCm39) H720Q probably benign Het
Pdxdc1 T C 16: 13,694,023 (GRCm39) N133S possibly damaging Het
Prkar1a T C 11: 109,544,690 (GRCm39) I27T probably damaging Het
Rnf10 G T 5: 115,389,355 (GRCm39) H271N possibly damaging Het
Scn9a A G 2: 66,392,855 (GRCm39) S246P probably damaging Het
Sertad2 G T 11: 20,597,798 (GRCm39) probably benign Het
Slc22a5 A T 11: 53,782,058 (GRCm39) V103E probably damaging Het
Slc5a9 A T 4: 111,748,138 (GRCm39) F225I probably benign Het
Slc6a3 G A 13: 73,706,404 (GRCm39) probably null Het
Smcr8 A G 11: 60,669,287 (GRCm39) E145G probably damaging Het
Spen A T 4: 141,203,448 (GRCm39) D1726E possibly damaging Het
Sphkap A T 1: 83,254,552 (GRCm39) S779T probably damaging Het
Stag1 A T 9: 100,658,844 (GRCm39) N144Y probably damaging Het
Strada T C 11: 106,061,783 (GRCm39) H156R probably damaging Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Tas2r138 A C 6: 40,590,116 (GRCm39) D43E probably damaging Het
Tdpoz3 A T 3: 93,733,642 (GRCm39) K106* probably null Het
Trbv13-1 A G 6: 41,093,229 (GRCm39) D54G probably damaging Het
Ttc39b A G 4: 83,165,932 (GRCm39) V218A probably benign Het
Ttn G A 2: 76,611,203 (GRCm39) T15697I probably damaging Het
Ugt2b38 G A 5: 87,560,282 (GRCm39) T344I probably benign Het
Vmn2r94 T C 17: 18,477,908 (GRCm39) M168V probably benign Het
Wdr11 T C 7: 129,208,715 (GRCm39) probably benign Het
Wipf2 T C 11: 98,783,554 (GRCm39) probably benign Het
Zranb2 T A 3: 157,252,302 (GRCm39) probably null Het
Other mutations in Slc22a27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01994:Slc22a27 APN 19 7,887,108 (GRCm39) missense possibly damaging 0.93
IGL02516:Slc22a27 APN 19 7,842,176 (GRCm39) missense probably damaging 0.99
IGL02961:Slc22a27 APN 19 7,903,886 (GRCm39) missense probably damaging 0.99
PIT4544001:Slc22a27 UTSW 19 7,887,103 (GRCm39) missense probably damaging 1.00
R0172:Slc22a27 UTSW 19 7,843,201 (GRCm39) nonsense probably null
R0234:Slc22a27 UTSW 19 7,904,156 (GRCm39) start gained probably benign
R0234:Slc22a27 UTSW 19 7,904,156 (GRCm39) start gained probably benign
R0280:Slc22a27 UTSW 19 7,874,187 (GRCm39) nonsense probably null
R0561:Slc22a27 UTSW 19 7,857,527 (GRCm39) critical splice donor site probably null
R0597:Slc22a27 UTSW 19 7,843,249 (GRCm39) missense probably benign 0.00
R1005:Slc22a27 UTSW 19 7,904,116 (GRCm39) missense probably damaging 1.00
R1165:Slc22a27 UTSW 19 7,887,059 (GRCm39) splice site probably null
R1217:Slc22a27 UTSW 19 7,904,033 (GRCm39) missense probably benign 0.01
R1533:Slc22a27 UTSW 19 7,844,348 (GRCm39) missense possibly damaging 0.79
R1940:Slc22a27 UTSW 19 7,887,092 (GRCm39) missense probably damaging 1.00
R3714:Slc22a27 UTSW 19 7,903,815 (GRCm39) missense possibly damaging 0.75
R3959:Slc22a27 UTSW 19 7,887,414 (GRCm39) missense probably damaging 1.00
R4059:Slc22a27 UTSW 19 7,856,973 (GRCm39) splice site probably benign
R4249:Slc22a27 UTSW 19 7,903,244 (GRCm39) missense possibly damaging 0.64
R4748:Slc22a27 UTSW 19 7,903,241 (GRCm39) missense probably benign
R5220:Slc22a27 UTSW 19 7,843,303 (GRCm39) missense probably damaging 0.96
R5221:Slc22a27 UTSW 19 7,843,303 (GRCm39) missense probably damaging 0.96
R5232:Slc22a27 UTSW 19 7,843,303 (GRCm39) missense probably damaging 0.96
R5330:Slc22a27 UTSW 19 7,856,820 (GRCm39) missense probably benign 0.13
R5331:Slc22a27 UTSW 19 7,856,820 (GRCm39) missense probably benign 0.13
R5345:Slc22a27 UTSW 19 7,843,303 (GRCm39) missense probably damaging 0.96
R5427:Slc22a27 UTSW 19 7,856,753 (GRCm39) critical splice donor site probably null
R5534:Slc22a27 UTSW 19 7,903,996 (GRCm39) missense probably damaging 1.00
R5691:Slc22a27 UTSW 19 7,904,035 (GRCm39) missense possibly damaging 0.90
R5828:Slc22a27 UTSW 19 7,903,767 (GRCm39) missense probably damaging 1.00
R5878:Slc22a27 UTSW 19 7,904,122 (GRCm39) missense probably benign 0.01
R5918:Slc22a27 UTSW 19 7,887,411 (GRCm39) missense possibly damaging 0.91
R6185:Slc22a27 UTSW 19 7,903,953 (GRCm39) missense probably benign 0.14
R6901:Slc22a27 UTSW 19 7,903,944 (GRCm39) missense probably damaging 1.00
R7139:Slc22a27 UTSW 19 7,903,912 (GRCm39) missense probably damaging 1.00
R7336:Slc22a27 UTSW 19 7,904,054 (GRCm39) missense probably benign 0.02
R7502:Slc22a27 UTSW 19 7,903,747 (GRCm39) missense probably damaging 1.00
R7556:Slc22a27 UTSW 19 7,843,119 (GRCm39) missense probably damaging 0.98
R7737:Slc22a27 UTSW 19 7,874,127 (GRCm39) missense probably damaging 0.99
R7860:Slc22a27 UTSW 19 7,887,472 (GRCm39) critical splice acceptor site probably null
R8050:Slc22a27 UTSW 19 7,857,532 (GRCm39) missense probably benign 0.18
R8090:Slc22a27 UTSW 19 7,843,101 (GRCm39) splice site probably null
R8150:Slc22a27 UTSW 19 7,887,390 (GRCm39) missense possibly damaging 0.87
R8974:Slc22a27 UTSW 19 7,903,751 (GRCm39) missense probably damaging 1.00
R9246:Slc22a27 UTSW 19 7,874,209 (GRCm39) missense probably benign 0.36
R9425:Slc22a27 UTSW 19 7,874,156 (GRCm39) missense probably damaging 1.00
R9520:Slc22a27 UTSW 19 7,843,227 (GRCm39) missense possibly damaging 0.94
R9731:Slc22a27 UTSW 19 7,904,126 (GRCm39) nonsense probably null
RF012:Slc22a27 UTSW 19 7,903,949 (GRCm39) missense probably benign 0.07
Z1177:Slc22a27 UTSW 19 7,887,095 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02